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DietaryandMetaboliccompoundsaffectingchromatinDynamics/remodelingHistoneacetylationIndeed,histoneacetylationinmammaliancellsisdependentonATP-citratelyase,theenzymethatconvertsglucose-derivedcitrateintoacetylCoA.Histoneacetyltransferases(HATs)HATsinhibitorAlzheimer’sdiseaseHyperlipidemiasDiabetesInhibitoranacardicacidgarcinolHATsacetylatelysines,resultinginchargeneutralizationandamorerelaxed,open,andtranscriptionallyactivechromatinstructure.ActivatorsFunctionallocalizationglucoseH3K9,K18,andK27andH4K5,K8,andK12EthanolH3K9highcarbohydrate/fatratiodietH3K9ontheSGLT1geneOtherphysiologicalfactors(coldexposureandaging)H4K16HistoneDeacetylases(HDACs)HDACsarespecificdeacetylasesthatremovetheacetylgroupsoflysineresiduesofhistonetailsleadingtochromatincompactionandtranscriptionalrepression.ClassicalHDACs