QUADAS-2在诊断准确性研究的质量评价工具中的应用

doi檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪檪殏殏殏殏10．7543/j．issn．1006－9674．2013．03．004．QUADAS-2J．2013323201－208．QUADAS-2邬兰1，2，张永3，4，曾宪涛1，2，41234442000QUADASQualityAssessmentofDiagnosticAccuracyStudies2003。、。QUADAS2011QUADAS-2。QUADASQUADAS-2。QUADAS-2Ｒev-Man5．2。QUADAS-2ＲevMan5．2。QUADASQUADAS-2ＲevMan5．2MetaTheQUADAS-2ToolfortheQualityAssessmentofDiagnosticAccuracyStudyanIntroductionWULan12ZHANGYong34ZENGXian-tao1241DepartmentofStomatologyTaiheHospital2SchoolofStomatology3DepartmentofScientificＲesearchTaiheHospital4Evidence-BasedMedicineCenterTaiheHospitalHubeiUniversityofMedicineShiyanHu-bei442000ChinaAbstractSincetheQualityAssessmentofDiagnosticAccuracyStudiesQUADAStoolwasofficiallylaunchedforassessingthequalityofdiagnosisaccuracystudyin2003ithasbeenwidelyusedallovertheworld．Inpracticesomeexperiencesre-portsfeedbacksfromusersoracademicorganizationssuggestedthepotentialforimprovingthistool．Thereforeinordertoim-provethistooltheQUADASGroupreviseditandthenlaunchedQUADAS-2in2011．ComparedwithQUADASQUADAS-2deletedandimprovedsomeitemswhichwereeasilyconfuseddividedtheassessmentitemsintotheriskofbiasandtheappli-cabilityandprovidedsignalingquestionswhichcouldhelpjudgment．CurrentlyQUADAS-2hasbeenintegratedtoＲevMan5．2software．ThisarticlemakesabrieflyintroductionofQUADAS-2andshowhowweuseitinＲevMan5．2software．KeywordsQUADASQUADAS-2ＲevMan5．2softwareDiagnosticaccuracystudySystematicreviewMeta-analysis“”20122012A05020112011CZX0120102010017。1991－。1984－、、、Meta。[e-mail]。/Meta1。QUADASQualityAssessmentofDiagnosticAccuracyStudiesCochrane2－5。QUA-DAS2011QUADAS-262012CochraneＲevMan5．257。Co-chraneQUADAS-2。20131ＲeiviewManager5Meta5QUADAS-26。1QUADAS-2QUADASPennyWhitingDelphi2003·102·．QUADAS-2/Meta282003。AgencyforHealthＲesearchandQuality、CochraneCollaboration、U．K．NationalInsti-tuteforHealthandClinicalExcellence/MetaQUADAS4。2011DatabaseofAbstractsofＲeviewsofEffects2005006。QUADAS14、、、、、、、“”、“”、“”《Meta、》2。QUADAS、、QUADAS。/MetaQUADASQUA-DAS-246。2QUADAS-2QUADAS-246。QUADAS1－3。2．1QUADAS-2Moher49→→→。QUADAS-2QUADAShttp//．bris．ac．uk/quadas/．an-nals．org6。QUADAS-241。3。。QUADAS-21。1QUADAS-26·202·JHBUM201363231QUADAS-22．2QUADAS-242⑴⑵⑶⑷。。2QUADAS-22．2．1QUADAS-24。“”、“”“”“”、“”“”。“”“”2。“”。11。“”“”“”。2－“”“”“”。“”“”。3“”。20%～30%“”“”20%“”。2110。“”“”“”。·302·．QUADAS-22/4。“”“”“”。31。“”“”“”。2。“”“”“”。41。。。“”“”“”“”。“”。2～3。。“”“”“”。42×2。“”“”“”。2．2．23、、“”、“”、“”。。“”、“”“”。“”。1。。26①②③④lowriskhighriskunclearrisk2。、。·402·JHBUM20136323。3。。。2．3QUDAS-223。3QUADASQUADAS-2QUADAS3。QUADAS26。QUADASQUADAS-2。Cochrane“”、“”、“”QUADAS-2“”“”Cochrane“”“”。QUADAS-2611⑴QUADAS-2⑵QUADAS-2⑶QUADAS-2⑷/QUADAS-2⑸QUADAS⑹QUADAS-2。QUADAS-2。QUA-DAS-2。QUA-DAShttp//．bris．ac．uk/quadas/QUADAS-2、、、QUADAS-2AccessExcelWord。QUADASQUADAS-2CochraneHandbookforDiagnosticTestAccuracyＲeviewsQUA-DAS-212QUADS-2。3QUDAS-24ＲevMan5．2《ＲeiviewManager5Meta》5ＲevMan5．257。5．2QUADAS-2《Preoperativevascularevaluationwithcomputedtomographyandmagneticresonanceimagingforpan-creaticcancerameta-analysis》13Ｒev-Man5．2QUADAS-2。QUADAS-24。《ＲeiviewManager5Meta》5134·502·．QUADAS-2“Figures”“AddFigure”45“Ｒiskofbiasandapplicabilityconcernsgraph”“Next→Finish”6。45“Ｒiskofbiasandapplicabilityconcernssummary→Next→Finish”7。3QUADASQUADAS-21－46－7QUADASQUADAS-2QUADAS-21．2．3．*4．5．6．7．8．*9．*10．11．12．13．14．*CochraneDTA13－44Arslan2001Irie2001Lee2010Nishiharu1999Ｒamsay2004Sariano2004Schwarz2001Trede199711YesNoYesYesNoYesNoYes2YesYesUnclearYesYesUnclearYesUnclear3YesYesUnclearYesYesUnclearYesUnclearLＲUＲUＲLＲUＲUＲUＲUＲLCHCUCLCHCUCHCUC21YesYesNoYesYesNoYesYes2NoYesNoNoYesNoNoYesUＲLＲHＲUＲLＲHＲUＲLＲUCLCHCUCLCHCUCLC31YesYesNoYesYesNoYesYes2UnclearYesYesUnclearYesYesUnclearYesUＲLＲUＲUＲLＲUＲUＲLＲHCHCUCHCHCUCHCHC41NoNoYesNoNoYesNoYes2～3UnclearNoYesUnclearNoYesNoYes4UnclearYesYesUnclearYesYesYesYesHＲUＲLＲHＲUＲLＲUＲLＲLＲlowriskHＲhighriskUＲunclearriskLClowconcernHChighconcernUCunclearconcern．·602·JHBUM201363234567514⑴/Meta⑵⑶Meta⑷⑸⑹。QUADAS-24、、、。。QUADAS-2CASP3。“”、“”Cochrane“”“”。QUADAS-2。QUADAS-2。QUADAS-2ＲevMan5．257Co-chraneQUA-DAS-2。1．/MetaM．201369－90449－458．2WhitingPＲutjesAWＲeitsmaJBetal．Thedevelop-mentofQUADASatoolforthequalityassessmentofstudiesofdiagnosticaccuracyincludedinsystematicre-viewsJ．BMCMedＲesMethodol200310325．3．Meta、J．201246496－499．4ＲeitsmaJBＲutjesAWWhitingPetal．Chapter9Assessingmethodologicalquality．InDeeksJJBossuytPMGatsonisCeds．CochraneHandbookforSystematicＲeviewsofDiagnosticTestAccuracyVersion1．0．1．TheCochraneCollaboration2009M/OL．Availablefromhttp//srdta．cochrane．org/handbook-dta-re-views．·702·．QUADAS-25．ＲeiviewManager5MetaJ．20133216－16．6WhitingPFＲutjesAWWestwoodMEetal．QUA-DAS-2arevisedtoolforthequalityassessmentofdiag-nosticaccuracystudiesJ．AnnInternMed20111558529－536．7ＲeviewManagerＲevManComputerprogram．Ver-sion5．2．CopenhagenTheNordicCochraneCentreTheCochraneCollaboration2012．8WhitingPＲutjesAWDinnesJetal．Developmentandvalidationofmethodsforassessingthequalityofdi-agnosticaccuracystudiesJ．HealthTechnolAssess20048251－234．9MoherDSchulzKFSimeraIetal．Guidanceforde-velopersofhealthresearchreportingguidelin