TAN肿瘤相关中性粒细胞的研究新进展

1007－8738201410－1114－03张庆勇，罗春华，王群兴*4430032013－12－31;2014－06－08国家自然科学基金青年基金(81202303)张庆勇(1982－)，男，湖北宜昌人，技师，博士Tel:0717-6483519;E-mail:[e-mail]*Correspondingauthor，王群兴，E-mail:[e-mail]“N1”“N2”“N1”“N2”。TAN。TANTAN。。Ｒ730．3Ｒ392．11G353．11Atumor-associatedneutrophilsTAN1TAN。TAN“N1”“N2”2－3。TAN。1polymorphonuclearleukocytesPMN50%～70%。。4。TANTAN5。TAN-αtumornecrosisfactor-αTNF-α、-1interleukin-1IL-1、IL-12IL-867。2TANtumor-associatedmacrophagesTAM“M1”“M2”TAN2“N1”“N2”“N1”“N2”8。TAN。-βinterferon-βINF-βN1、CC2chemokineC-Cmotifligand2CCL2、CCL5TNF-α、CCL3、1intercellularadhesionmolecular-1ICAM-1FAS9T10。-βtransforminggrowthfactor-βTGF-βTANN2、CCL2、CCL511－12。3TAN113－14。15、。Fridlender12TGF-βTGF-βTGF-βTGF-βTAN、、CD8+TLY6G。“N1”。TANTANneutrophilelastaseNE9matrixmetalloproteinase9MMP-916。Houghton174111ChinJCellMolImmunol20143010DOI:10.13423/j.cnki.cjcmi.007136Lox-Stop-StopLSL-K-rasNE。NENELSL-K-ras/NE－/－NE-1insulinreceptorsubstrate-1IＲS-1IＲS-13phosphatidylinositol3-kinasePI3Kplatelet-derivedgrowthfactorreceptorPDGFＲ。TANMMP-916。MMP-9vascularendothelialgrowthfactorVEGF-2fibroblastgrowthfactor-2FGF-218。TANIL-8TANCXC2C-X-Cchemokinereceptor2CXCＲ2。IL-8。López-Lago19。。CXC5CXCchemokineligand-5CXCL5IL-8。CXCL5IL-8。。420－22TANTANJensen23CD66b+。Zhou24CXCL5。CXCL5TAN。CXCL5TAN。CXCL5TAN、。CXCL5。5TANTANTANTAM“N1”“N2”。TAN25。TANTAN。。1GaldieroMＲBonavitaEBarajonIetal．TumorassociatedmacrophagesandneutrophilsincancerJ．Immunobiology2013218111402－1410．2FridlenderZGSunJMishalianI．Transcriptomicanalysiscomparingtumorassociatedneutrophilswithgranulocyticmyeloid-derivedsuppressorcellsandnormalneutrophilsJ/OA．PLoSOne201272e31524．3GaldieroMＲGarlandaCJaillonSetal．TumorassociatedmacrophagesandneutrophilsintumorprogressionJ．JCellPhysiol201322871404－1412．4PhamCT．NeutrophilserineproteasesSpecificregulatorsofinflammationJ．NatＲevImmunol200667541－550．5Cortez-ＲetamozoVEtzrodtMNewtonAetal．Originsoftumor-associatedmacrophagesandneutrophilsJ．ProcNatlAcadSciUSA201210972491－2496．6ScapiniPLapinet-VeraJAGasperiniSetal．TheneutrophilasacellularsourceofchemokinesJ．ImmunolＲev2000177195－203．7HoughtonAM．Theparadoxoftumor-associatedneutrophilsfuelingtumorgrowthwithcytotoxicsubstancesJ．CellCycle2010991732－1737．8AllavenaPSicaAGarlandaCetal．TheYin-Yangoftumor-associatedmacrophagesinneoplasticprogressionandimmunesurveillanceJ．ImmunolＲev2008222155－161．9JablonskeJLeschnerSWestphalKetal．NeutrophilsresponsivetoendogenousIFN-betaregulatetumorangiogenesisandgrowthinamousetumormodelJ．JClinInvest201012041151－1164．10FridlenderZGAlbeldaSM．Tumor-associatedneutrophilsfriendorfoeJCarcinogenesis2012335949－955．11PiccardHMuschelＲJOpdenakkerG．OnthedualrolesandpolarizedphenotypesofneutrophilsintumordevelopmentandprogressionJ．CritＲevOncolHematol2012823296－309．12FridlenderZGSunJKimSetal．Polarizationoftumor-associatedneutrophilphenotypebyTGF-beta“N1”versus“N2”TANJ．CancerCell2009163183－194．13JaillonSGaldieroMＲDelPreteDetal．NeutrophilsininnateandadaptiveimmunityJ．SeminImmunopathol2013354377－394．14．J．2010175487－491．15．J．201219111－14．511110．16DumitruCALangSBrandauS．ModulationofneutrophilgranulocytesinthetumormicroenvironmentmechanismsandconsequencesfortumorprogressionJ．SeminCancerBiol2013233141－148．17HoughtonAMＲzymkiewiczDMJiHetal．Neutrophilelastase-mediateddegradationofIＲS-1accelerateslungtumorgrowthJ．NatMed2010162219－223．18EbrahemQChaurasiaSSVasanjiAetal．Cross-talkbetweenvascularendothelialgrowthfactorandmatrixmetalloproteinasesintheinductionofneovascularizationinvivoJ．AmJPathol20101761496－503．19López-LagoMAPosnerSThodimaVJetal．NeutrophilchemokinessecretedbytumorcellsmountalungantimetastaticresponseduringrenalcellcarcinomaprogressionJ．Oncogene201332141752－1760．20MichaelMGoldsteinDClarkeSJetal．PrognosticfactorspredictiveofresponseandsurvivaltoamodifiedFOLFOXregimenImportanceofanincreasedneutrophilcountJ．ClinColorectalCancer200664297－304．21PaesmansMSculierJPLecomteJetal．PrognosticfactorsforpatientswithsmallcelllungcarcinomaAnalysisofaseriesof763patientsincludedin4consecutiveprospectivetrialswithaminimumfollow-upof5yearsJ．Cancer2000893523－533．22SchmidtHSuciuSPuntCJetal．Pretreatmentlevelsofperipheralneutrophilsandleukocytesasin-dependentpredictorsofoverallsurvivalinpatientswithAmericanjointcommitteeoncancerstageⅣmelanomaＲesultsoftheEOＲTC18951biochemotherapytrialJ．JClinOncol200725121562－1569．23JensenHKDonskovFMarcussenNetal．Presenceofintratumoralneutrophilsisanin-dependentprognosticfactorinlocalizedrenalcellcarcinomaJ．JClinOncol200927284709－4717．24ZhouSLDaiZZhouZJetal．OverexpressionofCXCL5mediatesneutrophilinfiltrationandindicatespoorprognosisforhepatocellularcarcinomaJ．Hepatology20125662242－2254．25GregoryADHoughtonAM．Tumor-associatedneutrophilsnewtargetsforcancertherapyJ．CancerＲes2011717檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾檾2411－2416．(上接第1113页)23DiMeglioFCastaldoCNurzynskaDetal．Epithelial-mesenchymaltransitionofepicardialmesotheliumisasourceofcardiacCD117-positivestemcellsinadulthumanheartJ．JMolCellCardiol2010495719－727．24ZakharovaLNural-GuvenerHGaballaM