抗体结构的介绍

zzØPorterIgGIgzNCILC)Hz1.lightchainL21424kDLKappaklamndaλ22.heavychainH450~55055~75kD4~55μγαδεHLkλIgIgMIgGIgAIgDIgEzz§HL§N-V§C-CzVariableregionVLN1/2VL108-111HN1/5~1/4VH118V65~75zhypervariableregionHVR)frameworkregionFRVLHVR24~3450~5689~97VHHVR31~3550~5695~102VLVHHVR1HVR2HVR3.zcomplementarity-determiningregionCDRVLVHHVR1HVR2HVR3CDR1,CDR2,CER3,CDR3HzconstantregionC§LC1/2105HC3/4~4/5331~431§zdomain1101L2VLCL2HIgGIgAIgD4V1C3IgMIgE5V1C4)3βLHVCβz41VLVH2CLCH13IgGCH2IgMCH3C1qIgGCH24CH3CH4BNKFc51CH1CH2Hα-2223CH2CH34z§1§1959PorterPapainIgGIgGN2Fab1FcFabfragmentantigenbindingFabLHN1/2FabFab1/2HFd225VHCH1FcfragmentcrystallizableFcFcHCCH2CH3IgFcduanFcz§2§1960NisonoffIgGIgGC1FabFab2Fab2LFdHFdFd235VHCH1§Fab2FabFab2IgIgFcFc§FcFczJ1Jjoiningchain1IgAIgM15ku82μα2secretorycomponentSC1IgA275ku3IgAsecretorypieceSP4IgA