国际会议论文ppt

IdiopathicAdultNephroticSyndrome:AClinicopathologicalStudyandResponsetoSteroidinaSub-SaharanAfricanCountryLiShuangDaiQingZhengWeiRepoerters:ContentIntroductionofNSPatientsandMethodsResultsDiscussionConclusionIdiopathicnephroticsyndrome(NS)isdeterminedbyaproteinuriahigherthan3g/24hassociatedwithhypoalbuminemia,withnokidneyinflammatorylesionsorimmunecomplexdeposits.DefinitionClinicaltranslationpodocyteinjury25%-30%glomerulonephritisinadult50%ofglomerulonephritischronickidneydiseaseAimsofthestudyAEpidemiologyBClinico-biology.CHistologyDTherapeutics&ProgressionprofilePatientsteenyearsofageandaboveNephrologyDepartmentatAristideLeDantecUniversityHospitalduring2001.01to2010.10MethodsElectronicquestionnaireelaboratedbyEpiInfo3.3.2versionAnalysisDatacollectionPopulationdistributionResults(156outof202patientswereprimitive(77%)SymptomsLaboratorydetailsRenalbiopsyTreatmentsPrognosisAgethemeanagewas17.7-41.7yearsthegroupof15-25yearswasthemostrepresentativewith46％ofpatientsGendermenrepresented72％(112patients)womenrepresented28％(44patients)PopulationdistributionSymptoms40%63%hypertensionhypertensionwasfoundin63patients.edemaedemawasthemostfrequenttypeofpresentationfoundin98patients.Laboratorydetailsmeanserumprotein41.7-55.3g/lmeanserumalbumin10-30g/lmeanproteinuria2.2-11.4g/24hrenalinsufficiency44%(n=68)hypertriglyceridemia52.5%(n=82)Renalbiopsytreatmentlifestylemeasuresdrugtreatment•sufficentcaloricdiet(100%)•fluidrestriction(13.4%)•sodiumrestriction(95%)•alowpotassiumdiet(5.7%)•diuretics(91.5%)•antiproteinuricagents(43%)•ACE-inhibitors(100%)anticoagulation(8.4%)steroid(95.9%)alone(85.8%)Steroidtherapywithcyclophosphamide(7.6%)withazathioprine(2.5%)Prognosiscompleteremissionpatialremissionrelapse23.7%4.45%5.1%DiscussionPrevalenceAgeHistologyprogress77%41.2%12%Akpechi’sstudyDeme’studyPrevalenceofidiopathicNSourstudymeanageof29years02Ageourstudyagegroupof25-34yearsDeme’sstudyHistologyFSGS(局灶性节段性肾小球硬化)T.MN(微小病变型)MCD(膜性肾病)45.6%5%43.4%ourstudyDeme’study75%6%12%ThecauseofdifferencerenalbiopsyPROGRESS33%28%ChronickidneydiseaseTheprogresstowardschronickidneydiseasewasnotedin33%.RemissionInourstudytheprogressionwasfavorablewithremissionin57patient.ConclusionANSisfrequentinourcountryB.CRemissionisverylowDCommomlesion→FSGSEarlydiagnosisisimportant