水飞蓟素的药理学研究进展_喇明平

:(1979-),05:2006-12-01喇明平1陈梅花2(1,200000;2,810008):系统查阅近年来有关水飞蓟素的药理学研究报道,总结了草本植物水飞蓟的活性成分水飞蓟素的药理学研究进展,综述了水飞蓟素的成分对免疫系统的调节作用抗肝纤维化对乳腺癌细胞系的抑制作用对糖尿病大鼠主动脉非酶糖化及氧化的抑制作用预防顺铂肾毒性而不影响其抗癌活性对糖尿病植物神经病变以及保护肝细胞膜,促进被损伤肝细胞合成DNA及结构蛋白等药理作用本文还展望了水飞蓟素的良好应用前景:水飞蓟;水飞蓟素;药理学Q94691;Q9497835B1007-7731(2007)06-35-02ProceedingofPharmacologicalResearchonsilymarinLamingpingChenmeihuaAbstract:Afterscanningmanymaterialaboutsilymarininrecentyears,thearticlesumpharmacologicalResearchonsilymarinsuchaseffectofSilymarinondiabeticautonomicneuropathy,theeffectofsilymarinontheinhibitionofnonenzymaticglycationandoxidationinaortaofstreptozocin-induceddiabeticrats,inhibitoryeffectofsilymarindifferentbreastcancercelllinesandassociatedmolecularmechanism,protectiveeffectofsilymarinoncisplatin-inducednephrotoxicitywithoutinterferingwithitsantitumouractivity,protectlivercell,improverelationtoDNAandsoon,theaimisthatsilymarinhasagoodfutureKeywords:Silymarin;pharmacological,,,,,1,(flavonoid),(silymarin),(silybin,silybinin)(silidianin)(silichristin)3,(isosilybin,isosilibinin)C25H22O10,4821(taxifolin)1(conifery1alcolol),(flavonolignans),:::3111[1],,,,N-[2]22.1,Kupffer,Kupffer(cytokines,CK),(transforminggrowthfactorTGFB),TGF(ITo,),,(collagens),(proteoglycans)(fibronectin),TGF,,III(procollagen-IIIpeptide,PIIIP),ROS,,[3],,,(secondarybiliaryliverfibrosis),,[4]2.2MCF-7SK-BR-3,MCF-7,SK-BR-3Her-2AG825SK-BR-3,,,SK-BR-3Her-2,Her-2[5]2.335,AnhuiAgriSciBull2007,13(6):35-36(AGEs),pentosidine(LPO),,,LPOAGEs,pentosidine[6],[7-8]20%-40%,(DAN)[9],[10-11],[9]2.4(ciplatin,CP),[12-14],CP(BUN),(NO),(MDA);(SOD);BUNMDANO,SOD,CP,,,,CP[15]2.5,,T(CTL)(NK),,,CTLNK,[16]2.6,RNAI,RNA,,,DNA,,,[17]2.7,5-A2,5-(5-lipoxygenase)(leukotrienes,LTs),(cyciooxygenase)(prostaglandin,PG)(thromboane,TX)LTsLTB4LTC4/F4,-,,,,PGE2,,T(TNFa),cAMP,,PGE2,,TXA2:KupfferLTSIC5015umol/L,PGI2IC5045umol/L,PGI2IC5052umol/L,TXA2IC5069umol/L[18],,LTS,,,PGI2/TXA2330,,[19],,NIDDM[20]ZnSe,,,[21][1]BandopadhayM,Componentsofsilybummarianum[J]IndianJChen,1992,10(2):808[2],[J],2001,21(8):493-494[3]Leng-PeschlowEAlcohol-relatedliverdiseases-useoflegalonfortherapy[J]Pharmedicum,1994,2(1):22[4]SchroeterL,BigkG,Waldschimdt,etalSilymarininhibitsaccumulationofcollageninratbiliaryliverfibrosisIn:PhytotherapieZ,edsProceedingofthe6thcongressofphytotherapy[J]Berlin,1995,24[5],[J]2003,34(3):238-242[6],,,1997,18(1):59-61[7],,1989,14(9):557[8],,,1995,16(4):333[9],,,,2001,22(4):310-314[10],7[J],1997,22(6):372-373[11][J],1994,10(1):44-45[12]SugiharaK,etalEffectofcisplatininInVitroproductionoflipidperoxidesinratkidneycortexJapan[J]Pharamaco,l1987,44:71[13]ZhongJG,etalProtectionagainstcisplatin-inducedlipidperoxidationandkidneydamagebyprocaineinrats[J]ArchToxico,l1990,64:599(25)36,,,a,,,,,,Mg2+RCTBP,CO2,1,6--1,7-[11]Mg2+(RuDPase),Mg2+H+,RuDPase,Mg2+CO2,RuDPaseMg2+RuBP,Mg2+CO2,CO2PSIIPSI,,,Mg2+PSII,PSI,PSII,,[12]Mg2+,Fv,,PSIIPSII[13],,CO2,CO2,ChlaFv/FoFv/FmFd/FsF685/F736,,PS[14]5,,,,,,[1],,,.,1995,28():104-107[2],,1998,4(4):371-378[3],,,63RuBP,2001,27(6):930-934[4]FredeenAL,RaabTK,RaoIM,etalEffectsofphosphorusnutritiononphotosynthesisinGlycineMaxLMerr[J]Planta,1990,181:399-405[5]FoyerCHFeedbackinhibitionofphotosynthesisthroughsourcesinkregulationinleaves[J]PlantPhysiolBiochem,1988,264:483-492[6],,2000,27(4):328-331[7],,,2001,27(6):1000-1006[8],.,2001,27(5):489-494[9],AgataWIRubisco[J],1994,20(3):285-292[10],[J],1994,(1):17-18[11],,[J],2000,29:74-80[12],,,[J],1992,9(1):1-16[13]HortonF,BlackMT,Biochim,BiophyActa,1983,722:214-218[14],,,,2001,28(2):101-106(袁莉编,魏凤校)(36)[14]ZhongJG,etalProtectioneffectofprocaineonoxidativestressandtoxicitiesofrenalcorticalslicesfromratscausedbycisplatininvitro[J]ArchToxicol,1992,66:354[15],,,[J],,2000,27(7):332-333[16]SchroeterL,BigkG,Waldschimdt,etalSilymarininhibitsaccumulationofcollageninratbiliaryliverfibrosisIn:PhytotherapieZ,edsProceedingofthe6thcongressofphytotherapy[J]Berlin,1996,24[17]Leng-PeschlowE,strenge-HesseA,Themilkthistleandsilymarinashepatictherapeuticagents[J],Phytotherapie,1991,12(1):162[18]DemlowC,MurawskiN,deGrootH,eta,lScavengingofreactiveoxygenspeciesandinhibitionofarachidonicacidmetabolismbysilibuminhumancells[J]LifeScience,1996,58(18):1591[19],1995,4(4):199[20],,II,1993,13(12):725[21]1994,15(6):3(魏凤编,张杨林校)25