肾小球疾病中肾小管损伤的进展-罗昌霞

肾小球疾病中肾小管损伤的进展罗昌霞　综述　丁国华　张建鄂　审校　　【】　。　　【】　;[]R692.31　[]　A　[]1001-4594(2004)05-0691-04　　。1960,NealBricker。,,,。Marcussen,。。。1　,。。1.1　管型形成引起小管腔阻塞,。TannerEvan,。[1]。、　　withmoderatetoseverepulmonaryhypertension.IsrMedAssocJ,2002,2(9):684-689.2　YiglaM,NakhoulF,SabagA,etal.Pulmonaryhypertensioninpatientswithend-stagerenaldiseases.Chest,2003,123(5):1577-1582.3　AminM,FawzyA,HamidMA,etal.Pulmonaryhypertensioninpatientswithchronicrenalfailure:roleofparathyroidgormoneandpulmonaryarterycalcifications.Chest,2003,124(6):2093-2097.4　DimitriuA,NistorN,ConduracheT,etal.Thevalueofechocardiographyfortheassessmentofthecardiacimpairmentinchronicrenalfailureinchild.RevMedChirMedNatIasi,2000,104(4):64-66.5　ReisnerSA,AzzamZ,HalmannM,etal.Septaltofreewallcurvaturera-tio:anon-invasiveindexofpulmonaryarterialpressure.JAmSocE-chocardiogr,1994,7:27-35.6　AkmalM,BarndtRR,AnsariAN,etal.ExcessPHTinCRFinducedpul-monarycalcification,pulmonaryhypertensionventricularhypertrophy.Kid-neyInt,1995,47(1):158-163.7　HerreroJA,Alvarez-SalaJL,CoronelF,etal.Pulmonarydiffusingcapaci-tyinchronicdialysispatients.RespirMed,2002,96(7):487-492.8　GiaidA,YanagisawaM,LanglebenD,etal.Expressionofendothelin-1inthepatientswithpulmonaryhypertension.NEnglJMed,1993,328(24):1732-1739.9　BrooksDP.Roleofendothelininrenalfuctionanddysfunction.ClinExpPharmacolPhysiol,1996,23(4):345-348.10　YoungPRJr,RohrMS,MarterreWFJr.High-outputcardiacfailuresec-ondarytoabrachiocephalicarteriovenoushemodialysisfistula:twocases.AmSurg,1998,64(3):239-241.11　CrarksonMR,GiblinL,BromnA,etal.Reversalofpulmonaryhyperten-sionafterligationofabrachiocephalicorteriovenousfistula.AmJKid-neyDis,2002,40(3):E8.12　PandeyaS,LindsayRM.Therelationshipbetweencardiacoutputandac-cessflowduringhemodialysis.ASAIOJ,1999,45(3):135-138.13　D'AlonzoGE,BarstRJ,AyresSM,etal.Survivalinpatientswithprima-rypulmonaryhypertension.Resultsfromanationalprospectiveregistry.AnnInternMed,1991,115(5):343-349.(:2004-04-23)69120049245UrologyandnephrologyFMS,Sep2004,Vol.24NO.5:442000,Tamm-Horsfall。、Tamm-Horsfall,。Tamm-Horsfall,,Tamm-Hors-fall[2]。,CD3eTIL-2,T。,,,,。MeyerV2,[3]。。CAMP、NOCGMP、[4]。23、,[5]。。1.2　球囊粘连致小管颈阻塞Kriz,,。、,,。,,,,,,,,;,,,[6]。,,,“”,;,[7]。Meyer,,,,,,、,,“”,[3]。,kriz,。1.3　滤过的大分子物质对肾小管细胞的影响,。,。;,;[8,9]。NF-Kappb,IL-8、RANTES,-1;TGF-β;MAPERK,,;C3[10];。C5b-9,C5b-9,69220049245　UrologyandnephrologyFMS,Sep2004,Vol.24NO.5;,;C6[11]。Sugaya[12]。Rlarris[10]。、、。:-1,[13]。?,IGF-1、HGFTGF-β[14]。,。,,,。Tm,,TM,,、,[8～12]。,megalin,LDL,megalin;cublin,cublinB12,。,,cublinCublinmeglin[15]。,。H+-ATP,H+-ATPCl-CIC-5。H+-ATP,Na+-H+NHE3,NHE3,NHE3[16]。NHE3H+-ATP。。,“”。2　,T。。,。,。SCID[17]。,T,。SCID,T,,。CCR-1T[18]。。3　,。,、。、、。。,T、、。。,、、69320049245UrologyandnephrologyFMS,Sep2004,Vol.24NO.5。,。:,;,;[19]、,,。,AST-120(),ICAM-1、TGF-β、[20]。,。4　,。,。,。　　　1　TannerGA,EvanAP.Glomerularandproximaltubularmorphologyaftersinglenephronobstruction.AmJPhysiol,1989,36:1050-1060.2　GengaroPE,EdelsteinCL,SchrierRW,etal.RoleofpolymericTamm-Horsfallproteinincastformation:oligosaccharideandtubularfluidions.KidneyInternational,2001,59(3):932-940.3　JavatoB,OlsonJL,MeyerTW.Glomerularinjuryandtubularlossinadrimycinnephrosis.JAMSocNephrol,2001,12:1392-1400.4　CholJ,ChaoL.Theroleofadrenomedullinincardiovascularandrenalfunction.DrugNewsandPerspective,2002,15(8):511-518.5　TremuzziAndrea,GagliardiniElena,DonadoniChiara,etal.Effectofan-giotensinIIantagonismontheregressionofkidneydiseaseintherat.Kid-neyInternational,2002,62(3):885-894.6　KrizW,HartmannL,HosserH,etal.Podocyteisthemajorculpritac-countingfortheprogressionofchronicrenaldisease.MicroscopyresearchandTechnique,2002,57(4):189-195.7　LehirM,KellerC,EschmannV,KrizW.Podocytebridgesbetweenthetuftandbowmanscapsule:anearlyeventinexperimentalcrescenticglomerulonephris.JournaloftheAmericanJASN,2001,12(10):2060-2071.8　MoriiT,FujitaH,NaritaT,etal.Associationofmonocytechemoattractantprotein-1withrenaltubulardamageindiabeticnephropathy.JDiabetescomplicant,2003,17(1):11-15.9　TangS,LenngJC,AbeK,etal.AlbuminstimulateIL-8experessioninproximaltubularepithelialcellinvitroandvivo.JournalofClinicalInves-tigatio,2003,111(4):515-527.10　TangS,LaiKN,ChanTW,etal.TransrerrinbutnotalbuminmediatesstimulationofcomplementC3biosynthesisinhumanproximaltubularepithelialcellAmJOfKidneyDisease,2001,37(1):94-103.11　NangakuM,PippinJ,CouserWG.C6mediateschronicprogress-sionoftubulointerstitialdamageinratswithremnantkidneys.JAmSocNephrol,2002,13:928-936.12　KamijoA,KimuraK,SugayaT,etal.Urinaryfreefattyacidsboundtoalbuminaggratetubulointerstialdamage.KidneyInt,2002,62(5):1628-1637.13　NathKA,VercellittiIGM,GrandeJP,etal.Hemeprotein-inducedchronicrenalinflammation:Suppressiveeffectofinducedhemeoxyge-nae-1.KidneyInt,2001,59:106-117.14　WangSN,LapageJ,HirschbergR.GlomerularultrafiltrationandapicaltubularactionofIGF-1,TGF-beta,andHGFinnephriticsyndrome.Kid-neyInt,1999,56:1247-1251.15　GhristensenEI,BirnH.Megalinandcubilin:Synergisticendocyterecep-torsinrenaltubule.AmJPhysiol,2001,280:F562-F573.16　PiwonN,GuntherW,SchwakeM,etal.CIC-5CI-channeldisruptionim-pairsendocytosisinamousemodelforDent'sdis