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200810285IntJDigDis,October25,2008,Vol.28,No.5:(IBS),IBS,IBS;IBS(SIBO);IBSIBSIBS:;;RelationshipbetweenprobioticsandirritablebowelsyndromeXUXue2mei,WANGQiao2min.DepartmentofGastroenterolo2gy,AnhuiProvincialHospital,AnhuiMedicalUniversity,Hefei(230001),ChinaAbstract:Irritablebowelsyndromeisoneofthemostcommonfunctionalgastrointestinaldisorders,ofwhichthepathogene2sisisnotyetclear.Recently,theeffectsofintestinalmicrofloragetmoreandmoreattentioninthepathogenesisofirritablebowelsyndrome.Epidemiologicalproofandclinicalproofindicatethattheinfectionofgastrointestinalcaninducepostinfectiousirritablebowelsyndrome,somepatientsexistsmallintestinalbacteriaovergrowthanddysregulationofintestinalbacteria,anti2bioticcanrelivethesymptomsofsomepatientswithirritablebowelsyndrome.Sosomeoneconsiderthatusingprobioticsmaybeabeneficialandreasonablemethodforthepatientsofirritablebowelsyndrome.Keywords:Probiotics;Irritablebowelsyndrome;Intestinalmicroflora:230001:Email:wqmin928@163.com(IBS),[1]IBS,,,,,,,,1,,,,,,,,,,,,,Luckey[2],,2IBS2.1(PI2IBS),IBSSIBOMarshall[3],2069(IBD)IBS,,,IBS10.1%,27.5%,36.2%,(P0.01),IBSEsposito[4]IBS,SIBO,IBS,,Pimentel[5]812176,,163200810285IntJDigDis,October25,2008,Vol.28,No.5,,27%SIBOSIBOIBS2.2IBSIBS,IBSPimentel[6]IBS,Esposito[4]RifaximinIBS,IBSIBS[7]IBSIBS,OR2.343()IBD:,;;4IBSIBS,IBS[8],4(DSM9843,),,Niedzielin[9](LP299V),,IBS,[10211]LP299VIBSPeter[12]1106,110811010cfu/mL35624,1108cfu/ml,,,IBS[13],[14],,5IBSIBS,,,,,,,,5.1,IBS,IBS,IBS,:;;,5.2,IBSDunlop[15],IBSIBSIBS,,;IBSIBSIBS,,IBS,[16],,,263200810285IntJDigDis,October25,2008,Vol.28,No.55.3,,IgA,,,Hart[17]VSL#3IL210,Th1,IL210,CD80,TIFN2OMahony[18]IBSIL210/IL212,IBS,IL210/IL2125.4[19]IBS,IBSLlois[20],6,IBS,,IBS1LongstrethGF,ThompsonWG,CheyWD,etal.Functionalboweldisorders.Gastroenterology,2006,130:148021491.2LuckeyTD.Introduction:Thevillusinchemostatman.AmJClinNutr,1974,27:126621276.3MarshallJK,ThabaneM,GargAX,etal.Incidenceandepidemiologyofirritablebowelsyndromeafteralargewaterborneoutbreakofbacte2rialdysentery.Gastroenterology,2006,131:4452450.4EspositoI,deLeoneA,DiGregorioG,etal.Breathtestfordif2ferentialdiagnosisbetweensmallintestinalbacterialovergrowthandirritablebowelsyndromedisease:Anobservationonnonab2sorbableantibiotics.WorldJGastroenterol,2007,13:601626021.5PimentelM,ChatterjeeS,ChangC,etal.Anewratmodellinkstwocontemporarytheoriesinirritablebowelsyndrome.DigDisSci,2008,53:9822989.6PimentelM,ChatterjeeS,ChowEJ,etal.Neomycinimprovesconstipation2predominatirritablebowelsyndromeinafashionthatisdependentonthepresenceofmethanegas:Wubanalysisofadouble2blindrandomizedcontrolledstudy.DigDisSci,2006,51:129721301.7,,,..,2001,22:4522454.8NobaekS,JohanssonML,MolinG,etal.Alterationofintes2tinalmicrofloraisassociatedwithreductioninabodominalbloa2tingandpaininpatientswithirritablebowelsyndrome.AmJGastroenterol,2000,95:123121238.9NiedzielinK,KordeckiH,BirkenfeldB.Acontrolled,double2blind,randomizedstudyontheefficacyoflactobacillusplanta2rum299Vinpatientswithirritablebowelsyndrome.EurJGas2troenterolHepatol,2001,13:114321147.10SenS,MullanMM,ParkerTJ,etal.Effectoflactobacillusplanta2rum299voncolonicfermentationandymptomsofirritablebowelsyndrome.DigDisSci,2002,47:261521620.11NivaE,NaftalibT,HallakaR,etal.Theefficacyoflactobacil2lusreuteriATCC55730inthetreatmentofpatientswithirrita2blebowelsyndrome2adoubleblind,placebocontrolled,random2izedstudy.ClinicalNutrition,2005,24:9252931.12WhorwellPJ,AltringerL,MorelJ,etal.Efficacyofencapsula2tedprobioticbifidobacteriuminfantis35624inwomenwithirri2tablebowelsyndrome.AmJGastroenterol,2006,101:158121590.13KajanderK,KorpelaR.Clinicalstudiesonalleviatingthesymptomsofirritablebowelsyndromewithprobioticcombination.AsiaPacJClinNutr,2006,15:5762580.14BittnerAC,CroffutRM,StranahanMC,etal.Prescrit2assistprobiotic2prebiotictreatmentforirritablebowelsyndrome:Anopen2lable,partiallycontrolld,12yearextensionofapreviouslypublishedcontrolledclinicaltrial.ClinTher,2007,29:115321160.15DunlopSP,HebdenJ,CampbellE,etal.Abnormalintestinalpermeabilityinsubgroupsofdiarrhea2predominantirritablebowelsyndromes.AmJGastroenterol,2006,101:129521298.16MarshallJE,ThabaneM,GargAX,etal.Intestinalpermeabilityinpatientswithirritablebowelsyndromeafterawaterborneoutbreakofacutegastroenteritisinwalkerton,Ontario.AlimentPharmacolTher,2004,20:131721322.17Caballero2FrancoC,KellerK,DeSimoneC,etal.Modulationofhumandendriticcellphenotypeandfunctionbyprobioticbacte2ria.GastrointestLiverPhysiol,2007,292:G3152322.18OMahonyL,McCarthyJ,KellyP,etal.Lactobacillusandbifidobacteriuminirritablebowelsyndrome:symptomresponsesandrelationshiptocytokineprofiles.Gastroenterology,2005,128:5412551.19KirschR,RiddellRH.Histopathologicalalterationsinirritablebowelsyndrome.ModPathol,2006,19:163821645.20LlopisM,AntolinM,GuarnerF,etal.Mucosalcolonizationwithlactobacilluscaseimitigatesbarrierinjuryinducedbyexpo2suretotrinitronbenzenesulphonicacid.Gut,2005,54:9552959.(:2008204203)(:)363