益生菌治疗肠易激综合征的相关机制-姜彬言

△※230001R442．2R574．4A1006-2084201115-2358-03IBS。IBS、、、、。MechanismofProbioticsintheTreatmentofIBSJIANGBin-yanWANGQiao-min．DepartmentofGastroenterologyAnhuiProvincialHospitalofAnhuiMedicalUniversityHefei230001ChinaAbstractIrritablebowelsyndromeIBSisoneofthemostcommonfunctionalgastrointestinaldisor-dersofwhichthecauseandthepathogenesisisnotyetclear．Dysbacteriasmallintestinalbacterialover-growthandIBSarecloselyrelatedandrecentstudieshavesuggestedthatprobioticsmaybeaneffectivetreat-mentofIBS．HereistofocusonexaminingtherelatedmechanismandsafetyofprobioticsinthetreatmentofIBSsuchasadjustingdysbacteriainhibittingsmallintestinalbacterialovergrowthstrengtheningintestinalmucosalbarrierimprovingintestinalmucosalimmunityreducingvisceralhyperalgesiaandsoon．KeywordsProbioticsIrritablebowelsyndromeDysbacteriairritablebowelsyndromeIBS、、、。、、、、、、。、、、IBS、。。1400、、98%2003EFFCA1。、、2。。、。、、。Si4IBS/B/E＜1IBS。IBS5。、、-、、IBSIBS。IBS。22．1IBS。46。Barrett7IBS。、①、②③、8532201181715MedicalRecapitulateAug．2011Vol．17No．15、④。2．2IBS、、、8。9。2．3--IBSIBS1011IBS。IgAIgA1213IgA。IBSIBS14、α、interleukinIL1β15IL-101617IL-10/IL-12。18IL-10IL-2IL-10/IL-12。IBS19。。2．4IBSIBS。2021。22。23。2．5IBSIBS24PI-IBS。PI-IBS25。2．6IBS。3IBS、、、、、、。、、、。4、、、IBSIBSIBS、。、、。、、、、IBS、。1WorkingGroupReport．GuidelinesfortheevaluationofpmbioticsinfoodR．JointFoodandAgricultureOrganisationoftheUnitedNationsandTheWorldHealthOrganisation2007．9532201181715MedicalRecapitulateAug．2011Vol．17No．152．J．20061140-42．3．J．2007194397-398．4SiJMYuYCFanYJ．IntestinalmicroecologyandqualityoflifeinirritablebowelsyndromepatientsJ．WorldJGastroenterol200410121802-1805．5．J．20072710704-705．6．J．201030145-48．7BarrettJSCanaleKEGearryRBetal．Probioticeffectsonintesti-nalfermentationpatternsinpatientswithirritablebowelsyndromeJ．WorldJGastroenterol200814325020-5024．8．J．2004114242-246．9ZengJLiYQZuoXLetal．Clinicaltrialeffectofactivelacticacidbacteriaonmucosalbarrierfunctioninpatientswithdiarrhoea-predominantirritablebowelsyndromeJ．AlimentPharmaeolT-her2008289994-1002．10OhmanLIsakssonSLindmarkACetal．T-cellactivationinpa-tientswithirritablebowelsyndromeJ．AmGastroenterol200910451205-1212．11KirschRRiddellRH．HistopathologicalalterationsinirritablebowelsyndromeJ．ModPathol200619141638-1645．12．J．200411144-47．13PaturiGPhillipsMJonesMetal．ImmuneenhancingeffectsofLactobacillusacidophilusLAFTIL10andLactobacillusparacaseiLAFTIL26inmiceJ．IntJFoodMicrobiol20071151115-118．14OttaianoAPisanoC．CD40activationaspotentialtoolinmalignantneoplasmsJ．Tumori2002885361-366．15．DCs-J．201019189-93．16LiebregtsTAdamBBredackCetal．Immuneactivationinpa-tientswithirritablebowelsyndromeJ．Gastroenterology20071328913．17O'MahonyLMcCarthyJKellyPetal．LactobacillusandbifidobacteriuminirritablebowelsyndromesymptomresponsesandrelationshiptocytokineprofilesJ．Gastroenterology20051283541-551．18VinderolaGMatarCPerdigonG．Roleofintestinalepithelialcellsinimmuneeffectsmediatedbygram-positiveprobioticbacteriain-volvementoftoll-likereceptorsJ．ClinDiagnLabImmunol20051291075-1084．19ZouJDongJYuX．Meta-analysisLactobacilluscontainingquadrupletherapyversusstandardtriplefirst-linetherapyforHeli-cobacterpylorieradicationJ．Helicobacter200914597-107．20MaXMaoYKWangBetal．Lactobacillusreuteriingestionpre-ventshyperexcitabilityofcolonicDRGneuronsinducedbynoxiousstimuliJ．AmJPhysiolGastrointestLiverPhysiol20092964G868-G875．21WangBMaoYK．LactobacillusreuteriingestionandIKCachannelblockadehavesimilareffectsonratcolonmotilityandmy-entericneuronesJ．NeurogastroenterolMotil201022198-107．22RousseauxCThuruXGelotAetal．Lactobacillusacidophilusmodulatesintestinalpainandinducesopioidandcannabinoidre-ceptorsJ．NatMed200713135-37．23．CRDDRGD．2009．24BarbaraGStanghelliniVCremonCetal．Almostallirritablebowelsyndromesarepost-infectiousandrespondtoprobioticscon-troversialissuesJ．DigDis2007253245-248．25．TD．2006．2011-03-152011-05-261△2※1．2390002．230022R722．1A1006-2084201115-2360-03。、、、。、、、、、A2、CD14、。。PharmacotherapyforMconiumAspirationSyndromeZHANFeng1HUBo2．1．DepartmentofPedi-atricsChuzhouClinicalCollegeAnhuiMedicalUniversityChuzhou239000China2．DepartmentofPediat-ricstheFirstAffiliatedHospitalofAnhuiMedicalUniversityHefei230022ChinaAbstractMeconiumaspirationsyndromeMASisaseverediseaseofthetermneonate．Thesetreat-mentsofMASincludeventilatorysupportsurfactanttreatmentandinhalednitricoxideinadditiontophar-macologicaltreatments．Asfordrugtherapythereareantibioticsambroxolsteroidsaminophyllinerecombi-nanthumansuperoxidedismutasephospholipaseA2inhibitorscomplementCD14inhibitorsandangiotensinantagonists．Manynewerpharmacologicalmodalitiesoftreatmentdescribedherehavenotbeenevaluatedwithrandomizedcontroltrials．KeywordsMeconiumaspirationsyndromeDrugtherapyInflammationLunginjurymeconiumaspirationsyndromeMAS。、、。、。0632201181715MedicalRecapitulateAug．2011Vol．17No．15