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2012294MedicalInnovationofChinaFebruary．2012Vol.9No.4AustraliacompliancewithpublishedguidelinesJ．JPaediatrChildHealth20074312795－798．7AmericanAcademyofPediatricsCommitteeonDrugs．NaloxoneuseinnewbornsJ．Pediatrics1980653667－669．8AmericanAcademyofPediatricsCommitteeonDrugs．Naloxonedos-ageandrouteofadministrationforinfantsandchildrenaddendumtoemergencydrugdosesforinfantsandchildren．PediatricsJ.1990863484－485．9BoxDCochranD．SafereductioninadministrationofnaloxonetonewborninfantsanobservationalstudyJ．ActaPaediatr20069591083－1086．10ContributorsandReviewersfortheNeonatalResucitationGuide-lines．Internationalguidelinesforneonatalresuscitationanexcerptfromtheguidelines2000forcardiopulmonaryresuscitationande-mergencycardiovascularcareinternationalconsensusonscienceJ．Pediatrics200010629．11McGuireWFowliePW．Naloxonefornarcoticexposednewbornin-fantssystematicreviewJ．ArchDisChildFetalNeonatalEd2003884308－311．12MitchellANidayPBoultonJChanceGetal．Aprospectiveclini-calauditofneonatalresuscitationpracticesinCanadaJ．AdvNeonatalCare200226316－326．13De－CastroRMCabral－FilhoJECostaJAetal．Neonataltreat-mentwithnaloxonecausespermanenthyperalgesiainratsJ．BrazJMedBiolRes1993267747－751．14HasanRABenkoASNolanBMetal．CardiorespiratoryeffectsofnaloxoneinchildrenJ．AnnPharmacother200337111587－1592．15HerschelMKhoshnoodBLassNA．RoleofnaloxoneinnewbornresuscitationJ．Pediatrics20001064831－834．16CarbineDNFinerNNKnodelEetal．VideorecordingasameansofevaluatingneonatalresuscitationperformanceJ．Pediat-rics20001064654－658．17GibbsJNewsonTWilliamsJetal．NaloxonehazardininfantofopioidabuserJ．Lancet198928655159－160．18MorelandTABriceJEWalkerCHetal．Naloxonepharmacokinet-icsinthenewbornJ．BrJClinPharmacol198096609－612．192005AmericanHeartAssociationguidelinesforcardiopulmonaryre-suscitationandemergencycardiovascularcare．part13Neonatalre-suscitationguidelinesJ．Circulation200511224supplIV－188－IV－195．2011－12－13035300【】TPN。、、/、、、、SMOF。。【】SMOFThecharacteristicsandclinicalapplicationofLipidemulsionCHENJie．ThePeople'shospitalofXingCountyShanxi035300China【Abstract】Fatemulsionisoneofthenon－proteinenergyoftheTPN．Thetraditionallong－chaintriglyceridebasedonsoybeanhaspotentialriskonlipidperoxidationimmunosuppressioninducinginflammationdamagingendothelialsystemthenpeopledeveloptheMCT/LCT、fishoil、oliveoil、STG、SMOFandsoon．Thedifferentkindsoflipidemulsionslieinthedifferenttriglyceridesthatisthedifferentfattyacidscombinedtotheglycerol．Characteristicsofthedifferentfattyacidsmetabolismdecidedifferentusesofdifferentlipidemulsionsinclini-calapplication．【Keywords】LipidemulsionLCTMCTFishoilOliveoilSTGSMOFdoi10.3969/j．issn.1674－4985.2012.04.098Wretlind、parenteralnutritionPN1。PNPNefficientfattyacidEFAPN2。SMOFsoybeanMCToliveoilfishoil。—851—2012294MedicalInnovationofChinaFebruary．2012Vol.9No.4。、。。2～46～12medium－chaintriglycerideMCT14～24long－chaintriglycerideLCT。、ω－3、6、7、9。。。1LCTLCTω－6。、、。、、、、。LCTT、B3～5。NO6。、。、、、、、、8。LCT、3～5。。20%LCT250ml4h。11400～1900LCT、7。2/LCT/MCTLCT/MCT。LCTE89。MCTLCTMCFAmedium－chainfattyacid9。/50%50%。MCTLCT。101993MCT/LCTLCT。－LCT/MCTLCT。LCT/MCTLCT。LCT/MCT。LCT/MCT、LCT1112。LCT/MCT。1320%LCT/MCT。LCT/MCT、TG、ALB14。32090。ω－3polyunsaturatedfattyacidPUFAFAEPAC205ω－3DHAC226ω－3ω－3FAω－6FA7.61。EPADHA、。EPAPGE2LTB4、、、15。EPA、DHA1617。EE18。ω－3、、、。、、。—951—2012294MedicalInnovationofChinaFebruary．2012Vol.9No.4LCT/MCTLCT/MCT19。ω－3PUFA、、、20。ω－3、、、、、、2122。ω－323ARDSω－3、24。、25。26。4OliveOilEmulsion90。27。C181ω－9ω－9monounsaturatedfattyacidMUFA、80%20%ω－6PUFA。E。EFA28。、EFA29。、30。E。5/STGSTGLCTMCT、MCFALCFA。6TG4TGLCFAMCFA31。/6TGTG。STGLCT/31。STG。LCT//31。/STG/32。LCFAMCFAMCTMCT33。LCTSTGTPN34。、35、5d、、、P＜0.05P＞0.05。STG。TPNSTG、MCT/LCTLCT。2001LCT/MCT36。6SMOFSMOFsoybean、MCT、oliveoil、fishoilE。NationalInstitutesofHealthNIH1999ω－6、ω－3。ω－337。ω－338。。FurstSMOF。。。。1MacFieJ．ThedevelopmentoffatemulsionsJ．Nutrition1999641－645．2．J．199863107－109．3Sala－VilaABarbosaVMCalderPC．Oliveoilinparenteralnutri-tionJ．CurtOpinClinNutrMetabCare2007102165－174．—061—2012294MedicalInnovationofChinaFebruary．2012Vol.9No.44．J．200262100－103．5ChambrierCLauverjatMBouletreauP．Structuredtriglycerideemul-sionsinparenteralnutritionJ．NutrClinPract2006214342－350．6．J．199973118－120．7．J．2008435462－463．8UrichHPastoresSMKatzDPetal．Parenteraluseofmedium－chaintriglyceridesareappraisalJ．Nutrition1996124231－238．9BachACBabayanVK．MediumchaintriglyceridesanupdateJ．AmJClinNutr1982365950－962．10JiangZMZhangSYWangXRetal．Acomparisonofmedium－chainandlong－chaintriglyceridesinsurgicalpatientsJ．AnnSurg19932172175－184．11Martin－PenaGCulebrasJMHoz－PeralesLDetal．Effectsof2lipidemulsionsLCTversusMCT/LCTonthefattyacidcomposi-tionofplasmaphospholipidadouble－blindrandomizedtrialJ．JPENJParenterEnteralNutr200226130－41．12SmyrniotisVEKostopanagiotouGGArkadopoulosNFetal．Long－chainversusmedium－chainlipidsinacutepancreatitiscomplicatedbyacuterespiratorydistresssyndromeeffectsonpulmonaryhemody-namicsandgasexchangeJ．ClinNutr2001202139－143．13．/J．200814542－43．14．/54J．200729111783－1784．15．J．2006144243－247．16AugustssonKMichaudDSRimmEBetal．Aprospectivestudyofintakeoffishandmarinefattyacidsandprostatecance