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464392～3982000ActaZoologicaSinica*D.Annanie1000800.025～0.40µg/kg/dDBTCl7d22±2℃:=12h:12hDBTCl≥0.05µg/kg0.025～0.05µg/kg0.20～0.40µg/kg0.10µg/kgDBTCl-DBTCl7dED500.170.19µg/kg1999-09-292000-03-10*D.Annanie34E-mailannanie@public3.bta.net.cnPAHsPCBsDDTestrogenlikeGillesbyetal.1998McLachlan1985Waldock1983Smithetal.1991Thayer198450001998Nicoteraetal.1990Thayer1984Sherman1988T-B-Pen-ninksetal.1977Annanie1998Alam1993DBTLOsmondetal.1998Martinaetal.198711.17～835±5g22±2℃60±5%12hr12hrL:12hrD7dAlarch98%50%1.2570.0250.050.100.200.40µg/kgDBTCl10.90%17d24hr4mlCO237℃2hr1ml101ml403Kempinasetal.199841000r/min5min5minAlemanetal.1978Robbetal.197840Eddyetal.19895100～20033tRobbetal.197822.1DBTCl0.40µg/kg7d0.025µg/kg0.05µg/kg0.10µg/kg1DBTCl3934D.AnnanieATPWessenlletal.1982DBTClClearyetal.19881*Table1EffectsofDBTClonbodyandtestisweightinmiceDBTClg/kgDoseofDBTClNo.ofanimalsgInitialbodyweightgFinalbodyweightgaWeightoftestis0.00739.39±1.442.82±2.10.40±0.080.025738.58±1.838.10±1.10.34±0.090.05739.66±1.238.22±1.30.31±0.07b0.10739.85±1.635.12±1.4b0.29±0.07c0.20738.71±1.133.23±1.7c0.24±0.05c0.40740.21±1.532.22±2.1c0.22±0.06c*±Valuesaregivenasmean±SEaAverageweightsoftwotestesbcb&cshowsignificandifferencefromthecontrolgroupP0.05andP0.01respectively2.20.025µg/kg0.05～0.40µg/kg0.05µg/kg2DBTClAnnanie19980.05µg/kgDBTClT-2*Table2EffectsofDBTClonspermviabilitydensityandmorphologicalabnormalityinmiceDBTClµg/kgDoseofDBTClNo.ofanimals%Rateofsurvivalsperm×106/mlSpermdensity%Rateofspermabnormality0.00799.72±2.13.56±2.40.20±0.020.025798.93±1.93.52±1.30.18±0.040.05789.22±4.6b3.11±1.9b6.23±1.4c0.10768.55±3.8c2.64±2.6c16.48±2.1c0.20748.22±7.8c1.75±3.2c21.74±3.5c0.40718.31±5.2c0.92±4.1c29.22±2.3c*1SignsinthetablearesameasthoseintheTable1DBTCl-DBTCl493467dDBTClED500.170.19µg/kg11DBTClabc-Fig.1Dose-responserelationshipbetweenthespermsurvivalrateadensitybabnormalityratecinmalemiceandtheDBTCl2hDBTCl0.0250.05µg/kg2hr1.07%10.78%P0.050.10µg/kg1h31.15%P0.010.20µg/kg30min51.78%P0.010.40µg/kg15min81.69%P0.010.200.40µg/kgLichardetal.1984DBTCl0.0250.05µg/kg7d73.3%0.10µg/kg66.6%25.0%0.200.40µg/kg5934D.Annanie44.0%46.0%Hironobuetal.1987Jenaldetal.1996Kirubangaranetal.1988Robbetal.1978Fish1977Thayer1984ReferencesAlamM.S.R.HusainP.K.SethandS.P.Srivastava1993Ageandsexrelatedtobehavioralchangesinducedbydibutyltin-dilaurateinrats.Bull.Environ.Contam.Toxicol.502286～292.AlemanV.R.TrejoandE.Morales1978Asimpleandrapidtechniquetoisolateenrichedpopulationsofspermatocytesandspermatidsfromtheimmatureratstestis.J.Reprod.Fert.54467～75.AnnanieD.S.G.DaiX.L.ChenandY.Q.Zhang1998TheeffectsoftributyltinchlorideTBTClonperipheralbloodT-lymphocyteandspleenindexinmice.ChinaEnvironmentalScience184378～380.D.Annanie1998TBTClT-.184378～380.ClearyI.andJ.Boyer1988Toxicityofdibutyltinandtributyltinandotherorganotincompoundstohumanandexperimentalan-imals.Toxicology553l253～258.EddyE.M.andD.A.OBrien1989BiologyofgametematurationtransportandfertilizationInWorkingP.K.ed.ToxicologyoftheMaleandFemaleReproductiveSystems.NewYorkNewYorkPressInc..31～37.FishR.H.1977BioorganotinchemistryMetabolismoforganotincompoundsinmicrosomalmonooxygenasesystemsinmam-mals.J.Agric.FoodChem.2511～6.GillesbyB.E.andT.R.Zacharewski1998Exoestrogensmechanismsofactionandstrategiesforidentificationandassess-ment.Environ.Toxicol.Chem.1713～14.HironobuT.S.K.ShogoHidekiI.TetsuyaK.YukihishaK.YasuoandT.Souichi1987Effectsofmaternalex-posuretosixheavymetalsonfetaldevelopment.Bull.Environ.Contam.Toxicol.384580～587.JenaldR.C.andD.K.S.Murthy1996Embryo-andfetotoxicityofchromiumingestationallyexposedmice.Bull.Envi-ron.Contam.Toxicol.572327～334.KempinasDeG.J.D.SuarezaN.L.RobetsL.F.StraderJ.FerrellandJ.M.Goldman1998Fertilityofratse-pididymalspermafterchemicallyandsurgicallyinducedsympathectomy.Biol.Reprod.593897～904.KirubangranR.andK.P.Joy1988ToxiceffectsofmercuricchloridemethylmercuricchlorideandemisanAnorganicmercurialfungicideonovarianrecrudescenceinthecatfishClariasbatrachus.Bull.Environ.Contam.Toxicol.394448～452.LichardL.F.andA.C.Michael1984ImmuneModulationAgentsandTheirMechanisms.NewYorkMarcelDekkerInc.MartinaP.andK.Krista1987Effectofleadonreproductioninmalemice.Bull.Environ.Contam.Toxicol.39344869346～452.McLachlanJ.A.1985EstrogensinEnvironmentⅡ.Elsevier.NewYork.NicoteraF.andM.Pierluigui1990Tributyltinstimulatesinratsthymocytes.Biochem.Biophy.283146～50.OsmondJ.D.CG.PhalguniandU.Fatih1998SpermicidalactivityofmetallocenecomplexescontainingvanadiumⅣinhumans.Biol.Reprod.5851515～1526.PenninksA.H.W.SeneinandV.Krieken1977ToxicityoforganotincompoundsSuppressionofthymus-dependentim-munityinratbydibutyltindichlorideanddi-octyltindichloride.Toxicol.App.Pharmacol.423213～224.RobbG.W.andR.P.Amann1978Dailyspermproductionandepididymalspermreservesofpubertalandadultrats.J.Reprod.Fert.541103～107.ShermanR.LandF.Abber1988Relationshipoftoxicitygroupinorganotinmoleculesandeffectivenessofthecompoundsa-gainstleukimia.App.Organomet.Chem.2165～72.SmithB.andG.W.Bryan1991Theeffectsoforganometalliccompounds.App.Organomet.Chem.5691～97.ThayerJ.S.1984OrganotinCompoundsandLivingO