Exosomes在肿瘤发展与转移中的研究进展_郭杏丹

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Exosomes2013-07-01421001。E-mail408655176@qq.com。E-mailhexiusheng@hot-mail.com。Exosomes、mRNA、miRNA。Exosomesepithelial-mesenchymaltransitionEMT、。Exosomes、。ExosomesR730.23A1001-7399201312-1348-03Exosomes30~100nm。Exo-somes、、RNA1。ExosomesmiRNA。Exosomes。1ExosomesExosomesmultivesicular-bodyMVBMVBExosomes。NSF2。ExosomesExosomes3。heatshockproteinsHSP、CD63Exosomes4。ExosomesWnt-β-catenin5、6、。2Exosomes、miRNA、、。Exosomes、miRNA、。2.1ExosomesExosomes。Exo-somes。Exo-somesHSP、p53、phosphataseandtensionhomologdeletedonchromosometenPTENβ-catenin。2.1.1HSPExosomestransferringreceptorTFRHSP-70TFRHSP-70Exosomes。Lv7HSP-70ExosomesNK。Cho8HSP-70ExosomesmajorhistocompatibilitycomplexMHC。Exo-somesHSP-70。2.1.2p53p53。Levinep53-6tumorsuppressoractivatedpathway-6TSAP64CExosomes。DNAp531caveolin-1CAV14Cepider-malgrowthfactorreceptorEGFRExosomes、9。50%p53。p53。miRNAExosomesp53。Exosomesp53p53。2.1.3PTENPTENPTEN·8431·JClinExpPathol2013Dec291210。PTENPI3K-AKT。Putz11PTENExosomes。ExosomesPTENGSK-3βNotch-1Hes-1G0/G112。PTENGSK-3βHes-1ExosomesNotchPTEN/GSK-3βExosomes。Exosomes。。2.1.4Wnt-β-cateninWnt13。Wnt。β-cateninWnt。Korkut14WntEvennessInterrupted/Wntless/SprinterEvi/Wls/SrtExosomesWnt。ExosomesCD82CD9Exosomesβ-cateninβ-cateninβ-cateninWnt15。ExosomesFrizzledWntWnt16。WntExosomesWntExo-somes。、。2.2ExosomesmiRNAmiRNARNAmRNA3'UTR。miRNAmiRNA5。miR-NA/Exosomes17。Yang18ExosomesmiRNA。ExosomesmiRNA19。ExosomesmiRNAmiRNA。Exo-somesmiRNAs20、19。ExosomesmiR-NAmiRNA。2.3Exosomes。Exo-somes。21。King22HIF-1αExosomes。ExosomesExo-somesAlix23。2.4ExosomesExosomesmiRNAExosomes。ExosomesExosomes、、。Exosomes24。Rana25Exosomes。Exosomes、26Exosomes。3ExosomesExosomes。Exosomes。APCExosomesT。Exo-somesmiRNAmiRNA。Exosomes。。1vandenBoornJGDasslerJCochCetal.ExosomesasnucleicacidnanocarriersJ.AdvDrugDelivRev2013653331-5.2SüdhofTCRothmanJE.MembranefusiongrapplingwithSNAREandSMproteinsJ.Science20093235913474-7.3BatistaBSEngWSPilobelloKTetal.IdentificationofaconservedglycansignatureformicrovesiclesJ.JProteomeRes201110104624-33.4MathivananSJiHSimpsonRJ.Exosomesextracellularorgan-ellesimportantinintercellularcommunicationJ.JProteomics201073101907-20.5GrossJCChaudharyVBartschererKBoutrosM.ActiveWntproteinsaresecretedonExosomesJ.NatCellBiol201214101036-45.·9431·JClinExpPathol2013Dec29126HasegawaHThomasHJSchooleyKBornTL.NativeIL-32isreleasedfromintestinalepithelialcellsviaanon-classicalsecretorypathwayasamembrane-associatedproteinJ.Cytokine201153174-83.7LvLHWanYLLinYetal.AnticancerdrugscausereleaseofExosomeswithheatshockproteinsfromhumanhepatocellularcarcinomacellsthateliciteffectivenaturalkillercellantitumorre-sponsesinvitroJ.JBiolChem20122871915874-85.8ChoJALeeYSKimSHetal.MHCindependentanti-tumorimmuneresponsesinducedbyHSP70-enrichedExosomesgeneratetumorregressioninmurinemodelsJ.CancerLett20092752256-65.9YuXRileyTLevineAJ.Theregulationoftheendosomalcom-partmentbyp53thetumorsuppressorgeneJ.FEBSJ200927682201-12.10.PTENJ.2009252208-10.11PutzUHowittJDoanAetal.ThetumorsuppressorPTENisexportedinExosomesandhasphosphataseactivityinrecipientcellsJ.SciSignal20125243ra70.12RistorcelliEBeraudEMathieuSetal.EssentialroleofNotchsignalinginapoptosisofhumanpancreatictumoralcellsmediatedbyexosomalnanoparticlesJ.IntJCancer200912551016-26.13.WntJ.2005213351-4.14KorkutCAtamanBRamachandranPetal.Trans-synaptictransmissionofvesicularWntsignalsthroughEvi/WntlessJ.Cell20091392393-404.15ChairoungduaASmithDLPochardPetal.Exosomesreleaseofbeta-cateninanovelmechanismthatantagonizesWntsignalingJ.JCellBio201019061079-91.16LiDRenYNYangJetal.Apreliminarystudyontheinflu-enceofhumanplasmaExosomes-likevesiclesonmacrophageWnt5A-Ca2+pathwayJ.ZhonghuaXueYeXueZaZhi2011326404-7.17StoorvogelW.FunctionaltransferofmicroRNAbyExosomesJ.Blood20121193646-8.18YangMChenJSuFetal.Microvesiclessecretedbymacro-phagesshuttleinvasion-potentiatingmicroRNAsintobreastcancercellsJ.MolCancer201110117.19UmezuTOhyashikiKKurodaMetal.Leukemiacelltoendo-thelialcellcommunicationviaexosomalmiRNAsJ.Oncogene201332222747-55.20TanakaYKamoharaHKinoshitaKetal.ClinicalimpactofserumexosomalmicroRNA-21asaclinicalbiomarkerinhumane-sophagealsquamouscellcarcinomaJ.Cancer201311961159-67.21CasazzaADiConzaGWenesMetal.Tumorstromaacom-plexitydictatedbythehypoxictumormicroenvironmentJ.Onco-gene2013Apr22.doi10.1038/onc.2013.121.Epubaheadofprint.22KingHWMichaelMZGleadleJM.HypoxicenhancementofExosomesreleasebybreastcancercellsJ.BMCCancer201212421.23ParkJETanHSDattaAetal.Hypoxictumorcellmodulatesitsmicroenvironmenttoenhanceangiogenicandmetastaticpoten-tialbysecretionofproteinsandExosomesJ.MolCellPro-teomics2010961085-99.24HoodJLPanHLanzaGMetal.Paracrineinductionofendo-theliumbytumorExosomesJ.LabInvest200989111317-28.25RanaSMalinowskaKZollerM.ExosomaltumormicroRNAmodulatespremetastaticorgancellsJ.Neoplasia2013153281-95.26DiVizioDMorelloMDudleyACetal.LargeoncosomesinhumanprostatecancertissuesandinthecirculationofmicewithmetastaticdiseaseJ.AmJPathol201218151573-84.··IshidaMSekineSFukagawaTetal.Neuroendocrinecarci-nomaofthestomachmorphologicandimmunohistochemicalcharacteristicsandprognosis.AmJSurgPathol20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