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165200110翟茂林哈鸿飞(100871)1ab431,2040,[1],,,,,,k[2];,(PVA),,60[3],,,(),,pH,[4,5](pH),,,1985,,22,,[6,7],,:(1),[8],[9];(2)[10];(3)[11]11.1,3,11N,N2,41N,Nogaoka[12][13]N(polyNIPAAm),,,,,,,,,1.2,PVAPVA,[14],PVApolyNIPAAm(PVP)(PAAc)(PAAm)(PEO)(PHEMA),1.3,,,[15],[14]2322.1(),,,,,,Flory,:=-RTV0ln(1-)++2-RT001/3-120+RT(Ngel-Nsol)V0;RT;Flory;0;NgelNsol;,T,,1(1),2(2)3(3),2.2,,[16],,,,,,,,,,()(),,,,Peppas[17],,,[7,18],,,,,,,,,,Lustig[19](),6cm1cm0.3cm,,2.3,3242.3.1共聚单体的组成,,,,,[20,21],N(NVP)(HEMA),,[21]2.3.2交联密度的影响,,,PAAmN,N(Bis)[22],Bis5%,,,,,[7,14],,PVPPVAPHEMMAPEOPAAmPAAc,,,,,,,,2.3.3合成条件的影响,,,,,,(pH),,pH,HEMADMAMA()[23],pH,2.112.6pH3~8pH,,0.10.7,400%,,,,,33.1,,,,3.2,,,,,,,,253.3,,,,3.43.4.1烧伤涂敷物(HydrogelDressing),,,,,HDRAQUAGEL,,[24],,,3.4.2药物传输体系(DDS),,,,,,,,,,,3.4.3补齿材料HEMA,,,UVDybek[25]PVA3.4.4移植(implants)PVA3.4.5隐型眼镜PHEMA,PVPPVAPMAAc,PHEMA,[26],(JOL)PMMAPVA3.4.6生物分子细胞的固定化[15],,,,450,,:P.J.Flory;26;(IPNs)1PeppasNA.HydrogelsinMedicineandPharmacy.BocaRaton:CRCpress,19862NijenhuisKT.ThermoreversibleNetworks.BerlinHeidelberg:Springerverlag,19973MoriY,TokuraH,YoshikanaM.JMaterSci,1997,32:4914HoffmanAS.PolymPreprAmChemSoc,DivPolymChem,1990,3(1):2205,.,1999,2:376.,1997,2:287ZhaiMaolin,HaHongfei,YoshiiF,etal.RadiatPhysChem,2000,57:4598VyavahareNR.Polymer,1992,33(3):5939KopecekJ.JControlledRelease,1992,19(1~3):12110KwonGS.JControlledRelease,1992,22(27):8311HuZhibing,ZhangXiaoming,LiYong.Science,1995,269:52512NagaokaN,KubotaH,SafraniA,etal.Macromolecules,1993,26:738613ZhaiMaolin,YiMin,HaHongfei,etal.RadiatPhysChem,1998,52:31314.:[].:,199915,.,1995,4:20516AnsethKS,BowmanCN,PeppasLB.Biomaterials,1996,17:164717PeppasNA,MerrillEW.JApplePolymSci,1977,21:176318RamarajB,RadnakR.JApplPolymSci,1994,51:97919LustigSR,CaruthersJM,PeppasNA.Polymer,1991,32:34020DavisTP,HuglinMB.Macromolecules,1989,22:282421DavisTP,HuglinMB.Polymer,1990,31:51322CohenY,RomonO,KopelmanIJ,etal.JPolymSci,PartB,1992,30:105523BakerJP,BlanchHW,PrausnitzJM.JApplPolymSci,1994,52:78324RosiakJM,WlanskiP.RadiatPhysChem,1995,46:16125DybekK,KubisA,RosiakJM.Pharmazie,1992,47:27326CarenzaM.RadiatPhysChem,1992,39:4852001IUPAC200163072Brisbane,()Zn65.409(4)65.39(2)Kr83.798(2)83.80(1)Mo95.94(2)95.94(1)Dy162.500(1)162.50(3)()27