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附录ATheColdChainanditsLogisticsAuthors:Dr.Jean-PaulRodriguezandDr.TheoNotteboom1.OverviewWhileGlobalizationhasmadetherelativedistancebetweenregionsoftheworldmuchsmaller,thephysicalseparationofthesesameregionsisstillaveryimportantreality.Thegreaterthephysicalseparation,themorelikelyfreightcanbedamagedinoneofthecomplextransportoperationsinvolved.Somegoodscanbedamagedbyshockswhileotherscanbedamagedbyunduetemperaturevariations.Forarangeofgoodslabeledasperishables,particularlyfood,theirqualitydegradeswithtimesincetheymaintainchemicalreactionswhichratecanbemostlymitigatedwithlowertemperatures.Ittakestimeandcoordinationtoefficientlymoveashipmentandeverydelaycanhavenegativeconsequences,notablyifthiscargoisperishable.Toensurethatcargodoesnotbecomedamagedorcompromisedthroughoutthisprocess,businessesinthepharmaceutical,medicalandfoodindustriesareincreasinglyrelyingonthecoldchaintechnology.Thecoldchainreferstothetransportationoftemperaturesensitiveproductsalongasupplychainthroughthermalandrefrigeratedpackagingmethodsandthelogisticalplanningtoprotecttheintegrityoftheseshipments.SpecializationhasledmanycompaniestonotonlyrelyonmajorshippingserviceproviderssuchastheUnitedParcelService(UPS)andFEDEX,butalsomorefocusedindustryspecialiststhathavedevelopedanichelogisticalexpertisearoundtheshippingoftemperaturesensitiveproducts.Thepotentialtounderstandlocalrules,customsandenvironmentalconditionsaswellasanestimationofthelengthandtimeofadistributionroutemakethemanimportantfactoringlobaltrade.Asaresult,thelogisticsindustryisexperiencingagrowinglevelofspecializationandsegmentationofcoldchainshippinginseveralpotentialnichemarketswithinglobalcommoditychains.Wholenewsegmentsofthedistributionindustryhavebeenveryactiveintakingadvantageofthedualdevelopmentofthespatialextensionofsupplychainssupportedbyglobalizationandthesignificantvarietyofgoodsincirculation.Fromaneconomicdevelopmentperspective,thecoldchainenablesmanydevelopingcountriestotakepartintheglobalperishableproductsmarket.Fromageographicalperspective,thecoldchainhasthefollowingimpacts:Global.Specializationofagriculturalfunctionspermittingthetransportoftemperaturesensitivefoodproductstodistantmarkets.Enablesthedistributionofvaccinesandotherpharmaceuticalorbiologicalproducts.Regional.Cansupportthespecializationoffunctionsandeconomiesofscale,suchasspecializedlaboratories.Local.Timelydistributiontothefinalconsumer,namelygrocerystoresandrestaurants.2.EmergenceofColdChainLogisticsWhileglobalcommoditychainsarefairlymodernexpansionsinthetransportationindustry,therefrigeratedmovementoftemperaturesensitivegoodsisapracticethatdatesbackto1797whenBritishfishermenusednaturalicetopreservetheirfishstockpiles.Thisprocesswasalsoseeninthelate1800sforthemovementoffoodfromruralareastourbanconsumptionmarkets,namelydairyproducts.Coldstoragewasalsoakeycomponentoffoodtradebetweencolonialpowersandtheircolonies.Forexample,inthelate1870sandearly1880s,FrancewasstartingtoreceivelargeshipmentsoffrozenmeatandmuttoncarcassesfromSouthAmerica,whileGreatBritainimportedfrozenbeeffromAustraliaandporkandothermeatfromNewZealand.By1910,600,000tonsoffrozenmeatwasbeingbroughtintoGreatBritainalone.Thefirstreefershipforthebananatradewasintroducedin1903bytheUnitedFoodCompany.Thisenabledthebananatomovefromanexoticfruitthathadasmallmarketbecauseitarrivedinmarketstooripe,tooneoftheworld'smostconsumedfruit.Thetemperaturecontrolledmovementofpharmaceuticalsandmedicalsuppliesisamuchmoremoderntransitoptionthantheshippingofrefrigeratedorfrozenfood.Sincethe1950s,logisticalthirdpartycompaniesbegantoemergeandinstitutenewmethodsforsuccessfullytransportingtheseglobalcommodities.Beforetheiremergence,coldchainprocessesweremostlymanagedinhousebythemanufacturer.IntheUnitedStates,FoodandDrugAdministrationrestrictionsandaccountabilitymeasuresoverthestabilityofthecoldchainincitedmanyofthesecompaniestorelyonspecialtycouriersratherthancompletelyoverhaulingtheirsupplychainfacilities.Aspecializedindustrywasthusborn.Thevalueofthecoldchaininthepreservationofexpensivevaccinesandmedicalsupplieswasonlybeginningtoberecognizedwhentheselogisticalprovidersstartedtoappear.Asawarenessbegantogrow,sodidtheneedforefficientmanagementofthecoldchain.Therelianceonthecoldchaincontinuestogainimportance.Withinthepharmaceuticalindustryforinstance,thetesting,productionandmovementofdrugsreliesheavilyoncontrolledanduncompromisedtransferofshipments.Alargeportionofthepharmaceuticalproductsthatmovealongthecoldchainareintheexperimentordevelopmentalphase.Clinicalresearchandtrialsisamajorpartoftheindustrythatcostsmillionsofdollars,butonethatalsoexperiencesafailurerateofaround80%.AccordingtotheHealthcareDistributionManagementAssociation,ofthecloseto200billiondollarsinpharmaceuticaldistribution,about10%aredrugsthataretemperaturesensitive.Thismakesthecoldchainresponsiblefortransportinganear20billiondollarinvestment.Iftheseshipmentsshouldexperienceanyunanticipatedexposuretovarianttemperaturelevels,theyruntheriskofbecomingineffectiveorevenharmfultopatients.Temperaturecontrolintheship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