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胃肠间质瘤靶向治疗耐药的分子机制及治疗策略作者：徐佳，曹晖，XUJia，CAOHui作者单位：200127,上海交通大学医学院附属仁济医院普通外科刊名：中华胃肠外科杂志英文刊名：ChineseJournalofGastrointestinalSurgery年，卷(期)：2013,16(3)参考文献(29条)1.FrankelTL;ChangAE;WongSLSurgicaloptionsforlocalizedandadvancedgastrointestinalstromaltumors20112.GramzaAW;CodessCL;HeinrichMCResistancetoTyrosineKinaseInhibitorsinGastrointestinalStromalTumors20093.MenaAC;PulidoEG;Guillén-PonceCUnderstandingthemolecular-basedmechanismofactionofthetyrosinekinaseinhibitor:sunitinib2010(Suppl1)4.GoodmanVL;RockEP;DagherRApprovalsummary:sunitinibforthetreatmentofimatinibrefractoryorintolerantgastrointestinalstromaltumorsandadvancedrenalcellcarcinoma20075.MiettinenM;LasotaJHistopathologyofgastrointestinalstromaltumor20116.DuensingA;MedeirosF;McConartyBMechanismsofoncogenicKITsignaltransductioninprimarygastrointestinalstromaltumors(GISTs)20047.FletcherJA;RubinBPKITmutationsinGIST20078.vanOosteromAT;JudsonI;VerweijJSafetyandefficacyofimatinib(STI571)inmetastaticgastrointestinalstromalturnours:aphaseIstudy20019.HeinrichMC;OwzarK;CorlessCLCorrelationofkinasegenotypeandclinicaloutcomeintheNorthAmericanIntergroupPhaseⅢTrialofimatinibmesylatefortreatmentofadvancedgastrointestinalstromaltumor:CALGB150105StudybyCancerandLeukemiaGroupBandSouthwestOncologyGroup200810.AgaramNP;WongGC;GuoTNovelV600EBRAFmutationsinimatinib-naiveandimatinib-resistantgastrointestinalstromaltumors200811.TamC;RinkL;MerkelEInsulin-likegrowthfactor1receptorisapotentialtherapeutictargetforgastrointestinalstromaltumors200812.LieglB;KeptenI;LeCHeterogeneityofkinaseinhibitorresistancemechanismsinGIST200813.HeinrichMC;CorlessCL;BlankeCDMolecularcorrelatesofimatinibresistanceingastrointestinalstromaltumors200614.DemetriGD;vanOosteromAT;GarrettCREfficacyandsafetyofsunitinibinpatientswithadvancedgastrointestinalstromaltumourafterfailureofimatinib:arandomisodcontrolledtrial200615.NishidaT;TakahashiT;NishitaniASunitinib-resistantgastrointestinalstromaltumorsharborcis-mutationsintheactivationloopoftheKITgene200916.HeinrichMC;MakiRG;CorlessCLPrimaryandsecondarykinasegenotypescorrelatewiththebiologicalandclinicalactivityofsunitinibinimatinib-resistantgastrointestinalstromaltumor200817.MiselliFC;CasieriP;NegriTc-Kit/PDGFRAgenestatusalterationspossiblyrelatedtoprimaryimatinibresistanceingastrointestinalstromaltumors200718.AntonescuCR;BesmerP;GuoTAcquiredresistancetoimatinibingastrointestinalstromaltumoroccursthroughsecondarygenemutation200519.MahadevanD;CookeL;RileyCAnoveltyrosinekinaseswitchisamechanismofimatinibresistanceingastrointestinalstromaltumors200720.SakuramaK;NomaK;TakaokaMInhibitionoffocaladhesionkinaseasapotentialtherapeuticstrategyforimatinibresistantgastrointestinalstromaltumor200921.DemetriGD;WangY;WehrleEImatinibplasmalevelsarecorrelatedwithclinicalbenefitinpatientswithunresectable/metastaticgastrointestinalstromaltumors200922.KawaharaH;NoguchiK;KatayamaKPharmacologicalinteractionwithsunitinibisabolishedbyagerm-linemutation(1291T》C)ofBCRP/ABCG2gene201023.WhiteDL;RadichJ;SoveriniSChronicphasechronicmyeloidleukemiapatientswithlowOCT-1activityrandomisedtohigh-doseimatinibachievebetterresponses,andlowerfailurerates,thanthoserandomizedtostandard-dose201224.ZalcbergJR;VerweijJ;CasaliPGOutcomeofpatientswithadvancedgastro-intestinalstromaltumourscrossingovertoadailyimatinibdoseof800ragafterprogressionon400nag200525.GeorgeS;TrentJCTheroleofimatinibplasmaleveltestingingastrointestinalstromaltumor2011(Suppl1)26.MontemurroM;Sch(o)ffskiP;ReichardtPNilotinibinthetreatmentofadvancedgastrointestinalstromaltumoursresistanttobothimatinibandsunitinib200927.MontemurroM;GelderblomH;BitzUSorafenibasthird-orfourth-linetreatmentofadvancedgastrointestinalstromaltumourandpretreatmentincludingbothimatinibandsunitinib,andnilotinib:Aretrospectiveanalysis201228.PantaleoMA;NanniniM;DiBattistaMCombinedtreatmentstrategiesingastrointestinalstromaltumors(GISTs)afterimatinibandsunitinibtherapy201029.MussiC;RonellenfitschU;JakobJPest-imatinibsurgeryinadvanced/metastaticGIST:isitworthwhileinallpatients2010本文链接：