喷雾干燥粘壁的原因与解决途径_周学永

36620076　　　AppliedChemicalIndustryVol.36No.6Jun.2007:2007-04-26:(Q200611007);(2006XZ4):(1966-),,,,,。:027-63435189,E-mail:[e-mail]周学永,高建保(,　430081)　:。、。、、、。。、、、。。:;;:TQ028.6　　　:A　　　:1671-3206(2007)06-0599-04ReasonsforwallstickingduringspraydryingandcountermeasuresZHOUXue-yong,GAOJian-bao(CollegeofChemicalEngineeringandTechnology,WuhanUniversityofScienceandTechnology,Wuhan430081,China)Abstract:Thetypesandreasonsforwallstickingduringspraydryingwereanalysed.Therearethreetypesofwallsticking:halfwetmaterials,materialswithlowmeltingpoint,drypowder.Thewallstickingofhalfwetmaterialisconcernedtothestructure,fixingandoperationofspraydryingtowerandsprayer,themo-tionofhotairintower.Themeltingstickingoccurredwhenthemeltingpointofmaterialsislowerthanthedryingtemperature.Thewallstickingofdrypowderisconcernedtogeometricfigureofcyclonechamber,roughnessofwall,velocityofairandstaticcharge.Themethodsforresolvingthewallstickingwereputforward.Keywords:spraydrying;fogdrop;wallsticking　　,。、()、,。,,。,,。,,,,,,。,。,。1　　　3[1]:、。1.1　　　,。,。,,。36,、、、。1.2　　　,。,,。1.3　　　,,,。、、、[2]。,,。,。2　2.1　2.1.1　改良干燥塔的结构与材质　,,。,,。,,,,。,[3]。、,,。90℃,,[4]。,100℃,、,100～200℃,。,。2.1.2　合理选择雾化器　,,,。,,,。、、,,,。[5],,10mm,,。,,,、,。10,,[6-7]。,、,,。2.1.3　雾化器的正确安装　,。,,,。,,。,,。,,。2.1.4　选用适宜的操作工艺条件　,、。。,,,。,,,,,,,,。,,,,[8]。,,。。,,,,6006:,Δtm,;,[9],τd[10]:　τ=1.04×10-4d1.87　　　　　　　　(1)　　(1),,,。,,。,,[11]。　dptgα2=　　　　　　　　　(2)　d———,m;　p———,Pa;　α———,rad。　　,,。,[12],,[13]。　u0=BpρL　　　　　　　　　　　　(3)　u0———,m/s;　B———;　p———,Pa;　ρL———,kg/m3。　　,,、。,。2.1.5　热风在塔内的运动状态　。[14],,180m3/h120m3/h,1.5,,。,,,。,,,。。,,,,。,,。、,。,。,。。,。[15],,,();,,,,[13]。2.2　　　,。,。2.2.1　控制热风温度　,。,[1]。2.2.2　夹套冷却法　,,。2.2.3　添加辅料法　,,、,[16]。[17]、、、4,4、、,57～106℃,。2.2.4　低温喷雾干燥法　,,,。,,。80℃,,,,95℃。,,,,,。60136、,[18]。2.3　　　,,。2.3.1　采用冷空气吹扫　,。,,,。2.3.2　添加填料法　。30°[19],。,、,“”。2.3.3　消除静电法　[2],,、,[20]。3　　　,、。3:、、。3,。,,,。,,。,。:[1]　,,.[M].:,2003:60-72.[2]　MurtomaaaM,SavolainenbM,ChristiansenbL,etal.Stat-icelectrificationofpowdersduringspraydrying[J].Jour-nalofElectrostatics,2004,62:63-72.[3]　.[J].,1994,16(5):57.[4]　.[J].,2000(2):43-45.[5]　,,,.[J].,1999,26(5):275-277.[6]　RicherC,HirokazuO,KazumiD.Particledesignusinga4-fluid-nozzlespray-dryingtechniqueforsustainedreleaseofacetaminophenl[J].ChemPharmBull,2006,54(7):948-953.[7]KobayashiM.Newdryingtechnology:Lowtemperaturespraydrying[J].PDAJournalofGMPandValidationinJapan,2001,3(1):20-27.[8]MichaelM,MurphybK,KumarbS,etal.Effectsofprocessvariablesonthepowderyieldofspray-driedtrehaloseonalaboratoryspray-dryer[J].EuropeanJournalofPharma-ceuticsandBiopharmaceutics,2005,59:565-573.[9]　AlyssonLRR,WanderleyPO.Spraydryingconditionsandencapsulatingcompositioneffectsonformationandpropertiesofsodiumdiclofenacmicroparticles[J].PowderTechnology,2006,171:7-14.[10].[J].,1980(4):57-61.[11]MohamedNEA.Anatomizationtheoryforswirlnozzles[J].TransactionsofASAE,1978,21(1):70-74.[12]KincaidDC.Sprinklerpatternradius[J].TransactionsofASAE,1982,25(6):1668-1672.[13]HuangLX,KumarK,MujumdarcAS.Acomparativestudyofaspraydryerwithrotarydiscatomizerandpres-surenozzleusingcomputationalfluiddynamicsimulations[J].ChemicalEngineeringandProcessing,2006,45:461-470.[14],.[J].,1989,18(5):35-37.[15]GoulaAM,AdamopoulosKG.Spraydryingoftomatopulpindehumidifiedair:I.Theeffectonproductrecovery[J].JournalofFoodEngineering,2005,66:25-34.[16]YoshiiH,OhhashiT,FurutaT,etal.Enzymeencapsula-tionwithcrystaltransformationofanhydrousmaltoseoranhydroustrehalose[J].JournalofAppliedGlycoscience,2006,53(2):99-103.[17],,,.[J].,2006,28(1):18-20.[18],.[J].,2006,27(3):10-13.[19]DinaNM,MadhuB,ShailendraK,etal.Spraydriedex-cipientbase:Anoveltechniquefortheformulationoforal-lydisintegratingtablets[J]ChemPharmBull,2006,54(1):99-102.[20],,,.[J].:,2003,41(6):706-707.602