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:(1975-),,,,;E-mail:cdqiao@sdili.edu.cn.乔从德*(山东轻工业学院材料科学与工程学院,济南250353):,,,;PEG),,;()PEG,,,,:;;;,(),,,pH/,,,,,,,,,(),(PEG),,,,PEG),;PEG,()PEG,[1]1物理水凝胶111C)O)C)OH,)COOH)OHStver[2],pH-(1)/,Starodubtzev[3]PMAAPEGpHPEG,PEGPMAAPeppas[4,5]P(MAA-g-#23#3EG),pHMcCormick[6]PMA-g-MPEG,pHPeng[7](-co-)P(AA-co-MMA),Lutz[8]PEG-b-P(MEO2MA-co-OEGMA),-Mansur[9]PEGPVA,SAXSFTIR1[2]Figure1Schematicdepictionofthedependenceofthephasetransitionontemperature[2]112-Zhang[10]-PVA/PEG(2),PVA,PEG2/[10]Figure2SchematicrepresentationofthestructuralmodelandmechanismtopreventcrackdevelopmentinPVA/PEGDNhydrogels[10]113()Agrawal[11]PLA/PEO/PLA(3)Kornfield[12],DNA,PEG(/(PLGA)[13~16]Velthoen[17]PLLA-PEG(2215%(wt))-Gariepy[18]PEG-PNIPAM,,114(CD),Huh[19]#24#20103A-CDs(4)pHIchi[20]PEGA-CDsCesteros[21]PEGB-CDsHennink[22]8-armBFan[23]PEGC-CDs,,3[11]Figure3Representationofthenetworkthatisformedwhenneighboringmicellesoftherac-seriestriblocksassociate.ThemicellecoresareamorphousPLAdomains[11]4[19]Figure4Hydrogelconceptbasedoninclusioncomplexesbetweencholesterol(triangles)andB-CD(con-shapedstructures)moietiescoupledDhtostar-shaped8-armPEO[19]2化学水凝胶211,,,(,pH),Ali[24]CPEG/AAcpH(5),Peppas[25],212,:;;;,Zheng[26]-,365nm,254nm,(6),-#25#35,pH[24]Figure5pHdependentswellingofPEG/AAccopolymerhydrogelsofdifferentAAccontent:()50,(o)65,and(p)75%(wt)[24][27]Guymon[28],365nm,Anseth[29](PEG-b-D,Llacticacid)254nmPeppas[30](-g-)Gibson[31]365nmSannino[32],6-[26]Figure6PhotocrosslinkingandphotocleavageofPEG-NCatdifferentirradiationwavelengths(365nm/254nm)[26]213()Hu[33](7)Chatterji[34]Peppas[35]PEG600DMATEGDMAPEGMMAHEMA-co-MAA,PEGMMA/TEGDMA(50%),Kizilel[36]PEG-DAVP,,Kim[37]MA-PEG-SO3HpH,Kumar[38]#26#201037[33]Figure7GreenspheresrepresentPEGderivativeparticles,brownspheresvinylgroup,andcurvedlinedpolymerchains[33]214(),Sperinde[39](8),[40]8[39]Figure8Transglutaminase(TG)cross-linkingreactionwithglutaminamide-functionalizedPEGandpoly(lysine:phenylalanine)toformanetwork.Eachpoly(KF)moleculeisconsideredacross-linknodeforthepurposesofequilibriumswellingcalculations[39].2152001Sharpless[41],,,DNA,,/0,Malkou[42]PEG(9),PEG216Cho[43](PEGDA)(AA)PEG/PAA(10)pH,,PEGPAAAAB-,[44]Zhao[45]PEG-co-PCL,FT-IR,DSCWAXD,Rakovsky[46]#27#39[42]Figure9ModularapproachforhydrogelconstructionbasedonclickchemistryandPEG-basedbuildingblocks[42].PEG/PMMAPMMA10/[43]Figure10SchematicdiagramoftheprocessofPEG/PAAIPNspreparation[43].217),,,Kiuchi[47](11))Gitsov[48]/Sefton[49]/,Lopina[50]Cima-LopinaHarris[51][52]pH#28#20103,11[47]Figure11ThereactionofcrosslinkedPEGhydrogel[47].3展望,/0,,/0,参考文献:[1]TessmarJK,GopferichAM,MacromolBiosci,2007,7,23~39.[2]YinXC,StolverHDH.Macromolecules,2002,35,10178~10181.[3]PhilippovaOE,KaribyantsNS,StarodubtzevSG.Macromolecules,1994,27,2398~2401.[4]LowmanAM,PeppasNA.Macromolecules,1997,30,4959~4965.[5]Torres-LugoM,PeppasNA.Macromolecules,1999,32,6646~6651.[6]PoeGD,JarrettWL,ScalesCW,McCormickCL.Macromolecules,2004,37,2603~2612.[7]LiuGQ,DingXB,CaoYP,ZhengZH,PengYX.Macromolecules,2004,37,2228~2232.[8]FechlerN,BadiN,SchadeK,PfeiferS,LutzJF.Macromolecules,2009,42,33~36.[9]MansurHS,OrficeRL,MansurAP.Polymer,2004,45,7193~7202.[10]ZhangXY,GuoXL,YangSG,TanSX,LiXF,DaiHJ,YuXL,ZhangXL,WengN,JianB,XuJ.JApplPolymSci,2009,112,3063~3070.[11]AgrawalSK,Sanabria-DeLongN,TewGN,BhatiaSR.Macromolecules,2008,41,1774~1784.[12]LammertinkRGH,KornfieldJA.Macromolecules,2003,36,9154~9161.[13]LeeDS,JeongB,BaeYH.ProcIntSympControlledReleaseBioactMater,1996,23:228~229.[14]JeongB,BaeYH,KimSW.Macromolecules,1999,32:7064~7069.[15]PistelK,BittnerB,KollH.JControlledRelease,1999,59:309~325.[16]BittnerK,WittC,MaderK.JControlledRelease,1999,60:297~309.[17]VelthoenIW,TijsmaEJ,DijkstraPJ,FeijenJ.MacromolSymp,2008,272,13~27.[18]Rue-lGariepyE,LerouxJC.EurJPharmBiopharm,2004,58,409~414.[19]HuhKM,ChoYW,ChungH,KwonIC,JeongSY,OoyaT,LeeWK,SasakiS,YuiN.MacromolBiosci,2004,4,92~99.[20]IchiT,OoyaT,YuiN.MacromolBiosci,2003,3,373~380.#29#3[21]CesterosLC,RamirezCA,PecinaA,KatimeI.MacromolChemPhys,2007,208,1764~1772.[22]vandeManakkerF,vanderPotM,VermondenT,vanNostrumCF,HenninkWE.Macromolecules,2008,41,1766~1773.[23]FanMM,YuZJ,LuoHY,ZhangS,LiBJ.MacromolRapidCommun,2009,30.[24]AliA,HegazyE.JBiomedMaterResPartB:ApplBio,2006,81,168~174.[25]KeysKB,AndreopoulosFM,PeppasNA.Macromolecules,1998,31,8149~8156.[26]ZhengYJ,AndreopoulosFM,MicicM,HuoQun,PhamSM,LeblancRM.AdvFunctMater,2001,11,37~40.[27]ZhengYJ,MicicM,MelloSV,MabroukiM,AndreopoulosFM,KonkaV,PhamSM,LeblancRM.Macromolecules,2002,35,5228~5234.[28]ClapperJD,GuymonCA.Macromolecules,2007,40,1101~1107.[29]LuSX,AnsethKS.Macromolecules,2000,33,2509~2515.[30]KlierJ,ScrantonAB,PeppasNA.Macromolecules,1990,23,4944~4949.[31]GibsonSL,JonesRL,WashburnNR,HorkayF.Macromolecules,2005,38,2897~2902.[32]SanninoA,NettiPA,MadaghieleM,CoccoliV,LucianiA,MaffezzoliA,NicolaisL.JBiomedMaterRes,2006,79:229~236.[33]CaiT,WangGN,ThompsonS,MarquezM,HuZB.Macromolecules,2008,41,9508~9512.[34]PadmavathiNC,ChatterjiPR.Macromolecules,1996,29,1976~1979.[35]BodugozH,GuO,PeppasNA.JApplPolymSci,2007,103,432~441.[36]Kizile