淋巴细胞归巢及其分子基础-王晓蕾

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6.HinekA,BiolChem,1996,377:471~4807.KasaiKetal,JBiochem,1996,119:1~88.SanjuanXetal,Gastroenterology,1997,113:1906~19159.JackersPetal,Oncogene,1996,13:495~50310.Van-den-BruleFAetal,EurJCancer,1996,32A:1598~160211.SanjuanXetal,JPathol,1996,179:376~38012.GaspariniGetal,IntJCancer,1995,60:604~610(1998-06-15)王晓蕾 赵旭东 曹筱梅 贲昆龙(,650223)   淋巴细胞 归巢 粘附分子  。60,。,、、、(knockout),。,[1~5],。1.(highendothelialvenules,HEV),,(、、),(),HEV,。1~2。,、(1)[5]。1 [5]—42—《》19981852.、[3]。(lymphocytehomingreceptor,LHR),(addressin)。:(1)(selectinfamily),L、P、E-。(2)(inte-grinfamily),αβ。αα1~9,αE、L、M、V、X,IEL15,ββ1~88,21。13,6,β1、β2β7[2]。(3)(Ig-superfamily),ICAM-1~3、VCAM-1、CD31。(4)(chemokine)GPCR(Gpro-tein-coupledreceptorfamily),BLR-1[6](MAdCAM-1)。,CD44、VCAM-1、CD34。、L-,MAd-CAM-1、VCAM-1、PNAd、GlyCAM-1、E-P-(2)[5]。2 [5],(),。[5]。3.,,,,。Lawrence,P-E-,,,,“”,。1991,Butcher[7],,—43—《》19981854(3)[5],:(1):,。,,,。L-,E-P-。α4β7[8、9]。(2)G:1~3,Gαi,。2。(3):,“”,。。,。[α4α4β1、α4β7,β2LFA-1(αLβ2)、MAC-1(αMβ2)]。(4):,。,CD31,,(L-),,,。,。3 [5]HEV,。RhoGTP。  4,。,,。,425(5-×17CD31×5-=425)。、、,[2]。—44—《》19981854.、,、、,。,。(IL-2、IL-10、INF-γ、TGF-β、、),。,HEVMAdCAM-1,α4β7,。、、、,[10]。,,。,。。1.SpringerTA.Cell,1994,76:301~3142.ImhofBAetal.AdvImmunol,1995,58:345~4163..《》,1994,14(4):1~54..《》,1995,54~56,5.ButcherECetal.Science,1996,272:60~666.FosterRetal.Cell,1996,87:1037~10477.ButcherEC,Cell,1991,67:1033~10368.BerlinCetal.Cell,1995,80:413~4209.WangerNetal.Nature,1996,382:366~37010.SavinoWetal.ImmunolToday,1995,16(7):318~322(1998-03-24)XPurdueMichaelG.RossmannTimothyA.Springer,70%ICAM-1。。,ICAM-1。414PNAS,XICAM-1。ICAM-1,5,,。2,(loop),。。,。(WuC.ScienceNews,1998,153:263)DMPKCTG。DMPK3′CTG3~35,50~2000。LeomidasPhylactou,DMPKRNACTG。I,DMPKRNA3′,,。NatGenet,1998,18:378~381。(WunschH.TheLancet,1998,351:1036)—45—《》1998185

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