后抗生素时代我们如何征服细菌-郭晓奎

Vol．32No．11Nov．2012JournalofShanghaiJiaotongUniversityMedicalScience“”2011AA02A119NationalHighTechnologyResearchandDevelopmentProgramofChina2011AA02A119。1964—电子信箱[e-mail]。1674-8115201211-1401-03··200025“”“”。。、、。DOI10．3969/j．issn．1674-8115．2012．11．001R378AHowtoconquerbacteriainpost-antibioticera？GUOXiao-kui(DepartmentofMedicalMicrobiologyandParasitology，BasicMedicalCollege，ShanghaiJiaotongUniversity，Shanghai200025，China)［Abstract］Theoccurrenceofantibioticresistantbacteria，especiallypan-drugresistantbacteriamaymakenoantibioticsavailableforthetreatmentofinfectiousdiseases，whichwillleadtotheemergeofpost-antibioticera．Itisimperativetofindnewantibacterialdrugsorstrategiestosolvetheincreasinglyseriousproblemofdrugresistance．Theinventionstatusandapplicationprospectofnew-typeantibiotics，antimicrobialpeptide，bacteriophageandtraditionalChinesemedicinepreparationareintroducedinthispaper，whichmayprovidereferencefortheexplorationofantibacterialdrugstoconquerbacteriainpost-antibioticera．［Keywords］drugresistant;bacteria;control。。。。antibiotics。19101929。。。、methicillin-resistantStaphylococcusAureusMRSA122010－β－1“”3。。“”。、、、、。·1041·Vol．32。1、、、、。、。、、、500010。、。。。LipALpxC。LpxC4。102。。2antimicrobialpeptide、2000～700020～60、。1972Boman5Cecropin4000。。。Daptomycin。10ⅡⅢ。①②、③④。。3bacteriophageEdwardTwortFelixD’Herelle19151917。。FelixD’Herelle。BruynogheMaisin1921。2050。2040、、、、、。2040。·2041·No．11。67。。。。4probiotics。、、、。、、。。。。。①8②9③。。5、、、、10。“”。、、、、、、、、、、、、、、、。。。。。1DavisMFIversonSABaronPetal．Householdtransmissionofmeticillin-resistantStaphylococcusaureusandotherstaphylococciJ．LancetInfectDis2012129703－716．2ZaphC．WhichspeciesareinyourfecesJJClinInvest2010120124182－4185．3KumarasamyKKTolemanMAWalshTRetal．EmergenceofanewantibioticresistancemechanisminIndiaPakistanandtheUKamolecularbiologicalandepidemiologicalstudyJ．LancetInfectDis2010109597－602．4LinLTanBPantapalangkoorPetal．InhibitionofLpxCprotectsmicefromresistantacinetobacterbaumanniibymodulatinginflamma-tionandenhancingphagocytosisJ．MBio201235．5BomanHGNilssonIRasmusonB．InducibleantibacterialdefencesysteminDrosophilaJ．Nature19722375352232－235．6BruttinABrussowH．HumanvolunteersreceivingEscherichiacoliphageT4orallyasafetytestofphagetherapyJ．AntimicrobAgentsChemother20054972874－2878．7KumariSHarjaiKChhibberS．Bacteriophageversusantimicrobi-alagentsforthetreatmentofmurineburnwoundinfectioncausedbyKlebsiellapneumoniaeB5055J．JMedMicrobiol201160Pt2205－210．8FukudaSTohHHaseKetal．BifidobacteriacanprotectfromenteropathogenicinfectionthroughproductionofacetateJ．Nature20114697331543－547．9KimYMylonakisE．CaenorhabditiselegansimmuneconditioningwiththeprobioticbacteriumLactobacillusacidophilusstrainNCFMenhancesgram-positiveimmuneresponsesJ．InfectImmun20128072500－2508．10FengXYanDZhaoKJetal．ApplicationsofmicrocalorimetryintheantibacterialactivityevaluationofvariousRhizomacoptidisJ．PharmBiol2011494348－353．2012-11-05·3041·