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,,32,,,1StarkKetal.Lancet,2002;359(9310):95729652BlumbergEAetal.ClinInfectDis,2001;32:30723103YoungMDetal.JMedVirol,2001;64:2902298(2002206220)(518057)(RA),,RA,RARA(RA),,RA,,,,RARA,1%;400,0.32%0.34%RA,RARA,,RA[1],RA,RAA(TNFA)(2TNFA,2002254)1(IL-1)IL21AB,IL21BRAIL21,RAIL21BIL21E2,ÊÑ,IL21(IL21R)IL21,,(88),(Tol2lip)ö(IL21),TNF26(TRAF6),(MAPK)NF2JBÉ(AP2É),,[2]222IL21(IL21Ra),IL21RaRARA,IL21RaIL21B,MTX,,IL21RaöIL21B,472RA,150mgIL21Ra,35%,X[3],,IL21RaË6(IL-6)RAIL26,IL26,,;,(AIA),IL26AIA,,,IL26,,IL26IL21BTNFAmRNA,IL26mRNA,IL26IL21BTNFA[4](CIA),IL26CIA,Ê,[5]IL26,IL26[6]IL26RA,IL26(mAb)RA5RA,10mgIL26mAb,10(C),,[6](Aggrecanase),10%,,Glu(373)2Ala(374),,RA,RARA,CD36,,[7]Curtisn23(),,,(IL21ATNFA)22,RA[8],RA,,3222002255RA,,,[7]RA4(IL-4)IL24T,IL21TNF2AIL26IL28IL212,IL21IL21ÊTNF,IL24,,IL24RA1LgöIL24CIA,,,IL24IL21Ra,Ê[9]ÊIL24,,IL24RA[10],CIAIL24DC,CIA,,Th1[11],IL24RA(sVEGFr)(VEGF),,,VEGF,VEGFVEGF,,PEGsVEGFr,PEGsVEGFr,,,[12]VEGFRA,VEGFRAöCD4CD4,T,4,MHCÊB2,p561ckCD4+,TT,BCD4+T,CD4mAbCIA,T,T(APC),CD4+,RA,CD4(cM2T412)IgG1,,46,Fc,cM2T412,10mg,50%70%CD4,,20%42240%,,IL26,57%;,67%Ritchie20%,,550mgcM2T412,cM2T412,CD4,cM2T412CD4,CD4[13](OPN)OPNArg2Gly2Asp(RGD),RGDATB3,RA,OPN,ÊmAb(mAböLPS)RA,OPN,,mAböLPSOPN,OPN,mAböLPS,,,OPN,mAböLPS,OPN,mAböLPS,,OPN,,(CD31),mAböLPSCD31OPN,OPN[14],OPNRA,(ATB3)OPNRA,OPNRA,RA,IL210IL213TGF2BIFN2BCD25RA,,RARA,,RAdeCODERA,,,RA1FeldmannMetal.AnnuRevImmunol,2001;19:16321962PiecykMetal.ClinicalRheumatol,2001;15(5):78928013ArendWPetal.AnnuRevImmunol,1998;16:272554OhshimaSetal.ProcNatlAcadSciUSA,1998;95:52220022558222282265AlonziTetal.JExpMed,1998;187(4):46124686deHoogeASetal.AmJPathol,2000;157(6):2081220917SharmaGetal.PharmacolRevCommun,2001;11(3):21522238CurtisCLetal.JBiolChem,2000;275(2):72127249JoostenLAetal.ArthritisRes,1999;1(1):8129110MyersLKetal.ClinImmunol,2002;102(2):185219111MoritaYetal.JClinInvest,2001;107:12752128412MiotlaJetal.LabInvest,2000;80(8):11952120513DalesandroMRetal.Methods,1995;8:157216514YumotoKetal.ProcNatlAcadSciUSA,2002;99(7):455624561(20022052282002206210)4,,(VRE)(MRSA)()()IntralytixVREMRSA,,ö,Biophage,,,,,PhageTherapeutics3,,ExponentialVRE,É,[BiotechnolNews2002;22(12):34()]622