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20320160115ChineseJournalofTissueEngineeringResearchJanuary15,2016Vol.20,No.3P.O.Box10002,Shenyang110180:B:2095-4344(2016)03-00430-052015-11-20(1SchoolofStomatology,ZunyiMedicalUniversity,Zunyi563099,GuizhouProvince,China;2theSpecialKeyLaboratoryofOralDiseasesResearch,InstitutionofHigherEducationinGuizhouProvince,theKeyLaboratoryofOralDiseasesResearchofZunyiCity,Zunyi563099,GuizhouProvince,China;3GuiyangStomatologicalHospital,Guiyang550002,GuizhouProvince,China)YangLin,Master,SchoolofStomatology,ZunyiMedicalUniversity,Zunyi563099,GuizhouProvince,ChinaCorrespondingauthor:LiuJian-guo,M.D.,Professor,SchoolofStomatology,ZunyiMedicalUniversity,Zunyi563099,GuizhouProvince,China;theSpecialKeyLaboratoryofOralDiseasesResearch,InstitutionofHigherEducationinGuizhouProvince,theKeyLaboratoryofOralDiseasesResearchofZunyiCity,Zunyi563099,GuizhouProvince,ChinaSubjectheadings:Hydrogel;BoneRegeneration;TissueEngineeringFunding:theScientificInnovationTalentTeamFundofGuizhouProvince,No.[2013]4026;112312(156309925630993550002).[J].201620(3):430-434.DOI:10.3969/j.issn.2095-4344.2016.03.023ORCID:0000-0001-7968-0659()PubMedEBSCO-MEDLINE20002015hydrogelbonetissueengineeringbonedefectregenerationrepairpH([2013]4026)(SZXK-201207-04)(KY[2013]109)(SYJ[2012]47)([2014]41)ApplicationofintelligenthydrogelsinboneregenerationandrepairAbstractBACKGROUND:Intelligenthydrogelasanewmaterialiswidelyusedinbiologicalmedicine,tissueengineering,memoryelementswitch,biologicalenzymeimmobilizationandotherrelatedfields,andexhibitsgoodbiologicalcharacteristics.Intelligenthydrogelsprovideanewapproachforregenerationandrepairofboneandotherhardtissues.PubMedEBSCO-MEDLINE20002015142925027hydrogel,bonetissueengineering,bonedefect,regeneration,repair374263.ISSN2095-4344CN21-1581/RCODEN:ZLKHAH431[2013]109;JointFundofScienceandTechnologyDepartmentofGuizhouProvince,No.SY-J[2012]47;ScientificCooperationProjectofGuizhouProvinceandZunyiCity,No.[2014]41OBJECTIVE:Tosummarizethelatestdevelopmentsofintelligenthydrogelinthebiologicalmedicineandtissueengineeringinordertofindoutnewmethodsforregenerationandrepairofboneandotherhardtissues.METHODS:Acomputer-basedresearchofCNKI,PubMedandEBSCO-MEDLINEdatabaseswasperformedtoretrieverelevantliteraturesabouttheapplicationofintelligenthydrogelinregenerationandrepairofboneandotherhardtissuespublishedfrom2000to2015.Thekeywordswere“hydrogel,bonetissueengineering,bonedefect,regeneration,repair”inChineseandEnglish,respectively.RESULTSANDCONCLUSION:IntelligenthydrogelsareclassifiedintopH-sensitive,temperature-sensitive,light-sensitive,multiple-sensitiveandothersensitivehydrogels.Inordertoimprovethemineralizationabilityofthehydrogelandconstructthethree-dimensionalpolymerscaffoldofhydrogel,themainstructureofthehydrogelmaterialscanbemixedwithvarioussignalfactors,thusachievingthemulti-utilityandmulti-functionofthematerialsystem,whichwillbecomethedevelopmenttrendoftissueengineeringconstruction.Citethisarticle:YangL,GuanXY,ChenLM,LiuJG.Applicationofintelligenthydrogelsinboneregenerationandrepair.ZhongguoZuzhiGongchengYanjiu.2016;20(3):430-434.0Introduction[1]1Dataandmethods1.1PubMedEBSCO-MEDLINE20002015hydrogelbonetissueengineeringbonedefectregenerationrepair1.21.3142925063272Results2.12.1.1[2]Ma[3]siRNAsiRNAsiRNAKim[4]122.1.2pHpHpHpHpHpHpH[5]Cheng[6]DNADNApH1min[6].P.O.Box10002,Shenyang110180[7]Cai[8]2.1.4pHCho[9]37Wu[10]L68mum/s2.1.52.22.2.1Gkioni[11][12][11]123[13][14]X3060nm2.2.2[15][16][17-18]3D[19]/.ISSN2095-4344CN21-1581/RCODEN:ZLKHAH433[20]S[21]3D[22][23]MTGase/2.2.3()3D[24]84.2%100μm87.5%20%0.31MPa/Moshaverinia[25](Arg-Gly-AspRGD)5mmRGDRGDRGDSun[26]//β-GP[27]N1410%N20%3%280450μm61%10d3Problemsandprospects[24].P.O.Box10002,Shenyang110180[1]BajpaiAK,ShuklaSK,BhanuS,etal.ResponsivePolymersInControlledDrugDelivery.ProgPolymerSci.2008;33(11):1088-1118.[2]HamleyIW,ChengG,CastellettoV.AThermoresponsiveHydrogelBasedonTelechelicPEGEnd-CappedwithHydrophobicDipeptides.MacromolBiosci.2011;11(8):1068-1078.[3]MaZ,YangC,SongW,etal.ChitosanhydrogelassiRNAvectorforprolongedgenesilencing.Nanobiotechnology.2014;19:12-23.[4]KimJK,YooC,ChaYH,etal.Thermo-reversibleinjectablegelbasedonenzymatically-choppedlowmolecularweightmethylcelluloseforexenatideandFGF21deliverytotreattypes1and2diabetes.JControlReleaseJ.ControlRelease,2014;194:316-322.[5]NandaJ,BiswasA,BanerjeeA.SingleaminoacidbasedthixotropichydrogelformationandpH-dependentmorphologicalchangeofgelnanofibers.SoftMatter.2013;(9):4198-4208.[6]ChengE,XingY,ChenP,etal.ApH-triggered,fast-respondingDNAhydrogel.AngewChemIntEdEngl.2009;48(41):7660-7663.[7]TsurkanMV,WetzelR,Perez-HernandezHR,etal.PhotopatterningofMultifunctiona