智能型水凝胶改性研究进展-王斌

:2005-06-06.:(1970-),,,,.:1672-691X(2006)01-0047-05智能型水凝胶改性研究进展王斌1,张玉翠2,张伏龙1,庄善学1(1.;2.,730000):,,.4.:;;IPN;:TQ314.2:A,pH.,:pH.,[1,2],.(,),;,,.4.1,.,.,.1.1F‚tima[3],,SWR2/D,S,R,D.,.,..N-(PNI-PAM),,,PNIPAM.NIPAM[4],.AndrewLyon[5](BM)N-PNIPAM/PBMA.,NIPAM(N,N-N-)[6,7].,pH:[8].JonesN--[9].1.2,,.,,.,,第20卷第1期甘肃联合大学学报(自然科学版)Vol.20No.12006年1月JournalofGansuLianheUniversity(NaturalSciences)Jan.2006[10].[11]N-(PNIPAM),DSC,,.,,,.Zhang[12]400PNIPAM.[13]CaCO3,PNIPAM,,,,10min90%.,.Zhang[14](N-/),.1.3(),.,,,.Yoshlda[15](PNIPAMPNIPAM),,,,(20min).Ju[16](PNIPAM)PNIPAM/PH/,:,10min,.2,,.,.(in-situ):,(pH).,,:,,,,.,,[17~19][20][21][22].(PEG)(PLA);(PBT)(PEG-PBT).,,,-,,(),.[23](PEG)E-(CL),PEG-b-PCL,,3.2,2--2-,,..,,;PEG,,.3,,.,..:,[24];48甘肃联合大学学报(自然科学版)第20卷,.[25]..Osada:()(16-),,pH-[26].,,.,Osada[27]11-(4c-),.,,.--,.,,.,.4(IPN),,.,.,[28](),,..IPN.IPN,;IPN,.,,.IPN[29~33].,[34]PNIPAM(MMA)IPN.,PNIPAM,PNIPAM/PMMAIPN,.,IPNPNIPAM,PNI-PAM;IPNPNIPAM.IPN,,pH.pH/(N-)IPN.,IPN.,,,/0,/0,,.IPN,,,,,IPN,IPN.,pH;(),;.,,.:[1]TOkano,AKikuchi,YSakuraietal.Temperaturere-49第1期王斌等:智能型水凝胶改性研究进展sponsivepoly(N-isopropylacrylamide)asamodulatorforalterationofhydrophilic/hydrophobicsurface[J].JControlledRelease,1995,36(1):125-133.[2]HCicek,ATuncel.Immobilizationofchymotrypsininthermallyreversibleisopropylacrylamide-hydroxyethy-lmethacrylatecopolymergel[J].JPolymSci,PartA:PolymChem,1998,36(4):543-552.[3]RF‚tima,BJo„ao,CMiguel.KineticsofwaterabsorbencyinAA/AMPScopolymers:applicationsofadiffusion-re-laxationmodel[J].Polymer,2002,43:63-67.[4]HMCrowther,BVincent.Swellingbehaviorofpoly-N-isopropylacrylamidemicrogelparticlesinalcoholicsolu-tions[J].ColloidPolymSci,1998,276(1):46-51.[5]DGan,L.ALyon.Tunableswellingkineticsincore-shellhydrogelnanoparticles[J].JAmChemSoc,2001,123(31):7511-7517.[6]ASE-IEjmi,MBHuglin.Thermoreversiblebehaviourinwaterofchemicallycrosslinkedpoly(2-methoxyethylacry-late-co-N,N-dimethylacrylamide)[J].PolymerInterna-tional,1997,44(3):277-282.[7]PHazot,JPChapel,CPichotetal.Preparationofpoly(N-ethylmethacrylamide)particlesviaanemulsion/pre-cipitationprocess:Theroleofthecrosslinker[J].JPolym.Sci.,PartA:Polym.Chem.2002,40(11):1808-1817.[8]BRSaunders,HMCrowther,BVincent.Poly[(methylmethacrylate)-co-(methacrylicacid)]microgelparticles:swellingcontrolusingpH,cononsolvencyandosmoticde-swelling[J].Macromolecules,1997,30(3):482-487.[9]CDJones,LALyon.Synthesisandcharacterizationofmultiresponsivecore-shellmicrogels[J].Macromole-cules,2000,33(22):8301-8306.[10]azuyaS,TakeshiS,YukoT,etal.Thermo-responsivereleasefrominterpenetratingporoussilica-poly(N-iso-propylacrylamide)hybridgels[J].JControlledRelease,2001,75(1):183-189.[11],.(N-)[J].,2004(1):46-49.[12]XZZhang,RXZhuo.Preparationoffastresponsive,thermallysensitivepoly(N-isopropylacrylamide)gel[J].EuropeanPolymerJournal,2000,36(8):2301-2303.[13],,.(N-)Ò.[J].,2002(3):354-357.[14]XZZhang,Ren-XiZhuo.Synthesisandpropertiesofthermosensitivepoly(N-isopropylacrylamide-co-methylmethacrylate)hydrogelwithrapidresponse[J].Mater-ialsLetters,2002,52(1):5-9.[15]RYoshida,KUchida,YKanekoetal.Comb-typegraf-tedhydrogelswithrapiddeswellingresponsetotemper-aturechanges[J].Nature,1995,374:240-242.[16]HKJu,SYKim,YMLee.pH/temperature-responsivebehaviorsofsem-iIPNandcomb-typegrafthydrogelscomposedofalginateandpoly(N-isopropylacrylamide)[J].Polymer,2001,42:6851-6857.[17]BJeong,YHBae,SWKim.ThermoreversiblegelationofPEG-PLGA-PEGtriblockcopolymeraqueoussolu-tions[J].Macromolecules,1999,32(21):7064-7069.[18]JMBezemer,RRadersma,DWGrijipmaetal.Zero-or-derreleaseoflysozymefrompoly(ethyleneglycol)/poly(butyleneterephthalate)matrices[J].JControlledRe-lease,2000,64:179-192.[19]HHLin,YLCheng.In-situthermoreversiblegelationofblockandstarcopolymersofpoly(ethyleneglycol)andpoly(N-isopropylacrylamide)ofvaryingarchitec-tures[J].Macromolecuels,2001,34(11):3710-3715.[20]RJHStenekes,HTalsma,WEHennink.Formationofdextranhydrogelsbycrystallization[J].Biomaterials,2001,22:1891-1898.[21]AMMathur,KFHammonds,JKlieretal.Equilibriumswellingofpoly(methacrylicacid-g-ethyleneglycol)hy-drogels:Effectofswellingmediumandsynthesiscond-itions[J].JControlledRelease,1998,54:177-184.[22]ATang,CWang,RJStewartetal.Thecoiledcoilsinthedesignofprotein-basedconstructs:hybridhydrogelsandepitopedisplays[J].JControlledRelease,2001,72:57-70.[23],.PEG-b-PCL[J].,2003(2):201-206.[24]JPGong,YOsada.Theoreticalanalysisofthecrosslink-ingeffectonthepolyelectrolyte-surfactantinteraction[J].JPhysChem,1995,99(27):10971-10975.[25]NIsogai,TNarita,LChenetal.Polymer-surfactantin-teractions:theircooperativityandstoichiometry[J].ColloidsandSurfacesA:PhysicochemicalandEngineer-ingAspects,1999,147:189-202.[26]TMiyazaki,KYamaoka,TKanekoetal.Hydrogelswiththeorderedstructures[J].ScienceandTechnologyofAdvancedMaterials,2000(1):201-210.[27]MTakashi,YKanji,JPGongetal.HydrogelswithCrystallineorLiquidCrystallineStructure[J].Macro-mol.RapidCommun.,2002,23:447-455.[28]KNeeraj,NVRavikumarMajeti,AJDomb.Biodegrad-ableblockcopolymers[J].AdvancedDragDeliveryRe-50甘肃联合大学学报(自然科学版)第20卷views,2001,53(1):23-44.[29]JRen,YZh