骨组织工程支架材料的降解和生物力学特性

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:10047220(2004)01005605TheMechanicalPropertiesandDegradationofScaffoldsforBoneTissueEngineering莫湘涛,秦廷武杨志明(,610041):,,:;;;:R31808:A,,,,,1989Lang[1],1994Bagambisa[2],,,,,,1,:(1):,5MPa,45MPa~100MPa[3](2):,,(3):60%~80%,100m,250m,200m,,90~200m,:20030527;:20030923:(1969),,,,::,Tel:(028)85422108,Fax:(028)85422432,Email:qtw@mcwcums.com5620043191JournalofMedicalBiomechanics,Vol.19No.1,March2004,,,[4],,pH,[5],(),,[5]2,21,,,,,:(1),(2),(3),,RodriguezLorenzo[6],,,21,5.5m,,,,,15Wiltfang[7]/,:16,60%;2880%,;685%,,,4~8,12,[8],,,,,[9]22,,,[10]221(demineralizedbonematrix,DBM)1973Urist[11],1975(AAA)[12],:49%31.50%98.4%,84.30%,25.90%,65%~77%17%98.4%88%,,222,57,Torford[13],Pelker[14];36.5%;,40%,Ennecking[15]6,,6,60%,20,2,223:(anorganticbone)OswestryBioOssKielKielOsevestryBioOss[16~18][19],,(BMP),[20],[10][21]:30%8h,,2241000!,,[22],,34,16,23,,[23]:()()(pH)()[5]231(Polylacticacid,PLA)PLA:PLLAPDLAPDLLA,PDLLA,(6~12)PLLAPDLA,,,(170!~180!);,12~30PLA,∀∀∀CO2[24],PLA[25],,Pistner[26]PLA:PLA,PLA,[27]PLLA,,24,,PLLA232(Polyglycolicacid,PGA),,,,PGA,4~8;;PGA,pH,233/(Polylactic/glycolicacid,PLGA)PLGA,Marra[28]PLGA(65/35)10%,,PLGA,85820043191JournalofMedicalBiomechanics,Vol.19No.1,March2004PLGA,40%,PLAPGAPLGA234(Polycaprolactone,PCL)PCLPLAPGA,,3PLA,,,,6,12PCL,,,[24]Marra[28]10%PCL+90%PLGA10%,PCL,Agrawa[24]PCL/,235(Polyhydroxybutyrate,PHB)PLA,,,Boerec[29]PHB,,3,,[30]XianmoDeng[31]PLA,,[32]/,,3,,,,,4,,,,,,,,,,,,,,,,,:[1]LangH,MertensT,GerlackKL.Reimplantationofhomologousculturedosteoblastlikecellsforimprovementofboneregeneration[J].IntOralMaxiSurg,1989,18(4):244248.[2]BagambisaFB,KappertHF,SchilliW.Interfacialreactionofosteoblaststodentalandimplantmaterials[J].JOral&Maxillo59,facSurg,1994,52(1):5256.[3].[J].,2001,18(4):647652.[4].[J].,2002,8(5):267269.[5]LuL,ZhuX,ValenzuelaRG,etal.Biodegradablepolymerscaffoldsforcartilagetissueengineering[J].ClinOrthop&RelatedRes,2001,(391,supple):S251270.[6]RodriguezlorenzoLM,ValletRegiM,FerreiraJM,etal.Hydroxyapatiteceramicbodieswithtailoredmechanicalpropertiesfordifferentapplications[J].JBiomedMaterRes,2002,60(1):159166.[7]WiltfangJ.MertenHA,SchlegelKA,etal.Degradationcharacteristicsofandtricalciumphosphate(TCP))inminipigs[J].JBiomedMaterRes,2002,60(1):115121.[8],,.[J].#,2001,22(1):58.[9],.[J].,2002,19(1):124126.[10],,,.[J].,2002,19(1):1012.[11],,.[J].#,1998,17(3):139142.[12]PerryCR.Bonerepairtechniques,bonegraft,andbonegraftsubstitutes[J].ClinOrthop&RelatedRes,1999,360:6871.[13]TomfordWW.DoppeltSH,MankinHJ,etal.Bonebankprocedures[J].ClinOrthop&RelatedRes,1983,174:1521.[14]PelkerRR.FriedlaenderGE,MarkhamTC.Biomechanicalpropertiesofallografts[J].ClinOrthop&RelatedRes,1983,(174):5457.[15]EnnekingWF,MindellER.Observationonmassiveretrievedhumanallografts[J].JBoneJointSurg(Am),1991,73(8):11231142.[16]OzakiT,InoueH,SugiharaS,etal.Radiologicallongtermfollowupofgraftedxenogeneicboneinpatientswithbonetumors[J].ActaMedOkayama,1992,46(2):8792.[17]ValentiniP,AbensurD.Maxillarysinusfloorelevationforimplantplacementwithdemineralizedfreezedriedboneandbovinebone(BioOss):aclinicalstudyof20patients[J].IntJPeriodonticsRestorativeDent,1997,17(3):232241.[18]ValentiniP,AbensurD,DensariD,etal.HistologicalevaluationofBioOssina2stagesinusfloorelevationandimplantationprocedure:ahumancasereport[J].ClinOrallmplantsRes,1998,9(1):5964.[19],,,.[J].,2002,14(6):365368.[20],,,.[J].,1998,14(5):277279.[21],,,.[J].,2002,17(2):122123.[22],,,.[J].,1998,12(2):9497.[23]EngelbergI,KohnJ.Physicomechanicalpropertiesofdegradablepolymersusedinmedicalapplications:Acomparativestudy[J].Biomaterials,1991,12(3):292304.[24]BradyJM,CutrlghtDE,MillerRA,etal.Resorptionrate,routeofelimination,andultrastructureoftheimplantsiteofpolylacticacidintheabandonminalwalloftherat[J].JBiomedMaterRes,1973,7(2):155166.[25],,.[J].,2001,14(4):308312.[26]PisterH,StallforthH,GutwaldR,etal.Poly(Llactide):alongtimedegradationstudyinvivo.Part∃:Physicomechanicalbehaviorofimplants[J].Biomaterials,1994,15(6):439450.[27],,.[J].,2001,16(3):135139.[28]MarraKG,SzemJW,KumtaPN,etal.Invitroanalysisofbiodegradablepolymerblend/hydroxyapatitecompositeforbonetissueengineering[J].JBiomedMaterRes,1999,47(3):324335.[29]BoereeNR,DoveJ,CooperJJ.etal.Developmentofadegradablecompositefororthopaedicuse:mechanicalevaluationofahydroxyopatitepolyhydroxybutyratecompositematerial[J].Biomaterials,1993,14(10):793796.[30]LiuQ,deWijinJR,vanBlitterswijkCA.Nanoapatite/polymercomposites:mechanicalandphysicochemicalcharacteristics[J].Biomaterials,1997,18(9):12631270.[31]DengX,HaoJ,WangC.Preparationandmechanicalpropertiesofnanocompositesofpoly(D,Llactide)withCadeficienthydroxyapatitenanocrystals[J].Biomaterials,2001,22(21):28672873.[32],,./[J].,2002,24(2),124128.6020043191JournalofMedicalBiomechanics,Vol.19No.1,March2004

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