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··DOI10.3877/cma．j．issn．1674-0785．2012．06．053100048、、、Emailliangsl304@hotmail．com【】VPALEVBECTLEVBECT。2008220091226BECTLEVVPA15。15111.38FIQ≥9021102.23。4～1515LEV8VPA72。LEV5513VPA6218。LEV2VPA350%LEV9VPA6。。LEVFIQ3.92VPA1.69。LEV4VPA26。LEVBECTVPA。【】benignepilepsyofchild-hoodwithcentrotemporalspikesBECT。15%～24%1。levetirace-tamLEV2BECTvalproateVPALEV26BECTelectroencephalographyEEG。、1．20082200912BECT2613～103～1223EEG45366≥271.58、。LEVVPA13。2．intelligentquotientIQ。Biologic24h3。1.5TSiemensMRIT1、、T2、DWIFlairMRI。3～6、7～12IQFIQ。3．LEVUCBPharma．S．A．30052VPA307。LEV10mg·kg－1·d－18～10mg·kg－1·d－125mg·kg－1·d－135mg·kg－1·d－13LEVB65～20mg/d3。VPA10mg·kg－1·d－110mg·kg－1·d－120mg·kg－1·d－130mg·kg－1·d－1。4．15EEGIQIQ。4～151、≥50%＜50%。15、≥50%＜50%。FIQ＞5、＞2。5．ChisstP＜0.05。、1．2615111～21.38±0.7FIQ≥9021＜90570、。EEG、1。、、1。·2751·2012366ChinJCliniciansElectronicEditionMarch152012Vol．6No．61珋x±s珋x±sFIQ珋x±s%%%、%LEV6.69±1.258.08±1.02105.31±11.56646.2430.8215.4753.81061.5323.1215.4VPA7.15±1.408.54±1.0399.15±14.01969.2430.8430.8538.6753.8646.2430.8P0.49270.45700.31290.75180.60650.45330.12132．4～1515LEV8VPA7LEV3VPA42P=0.9005。LEV551376.4%VPA621871.0%P=0.6025。3．LEV2VPA3150%LEV9VPA6LEV2VPA4P=0.4940。4．LEVFIQ3103.92±1.76VPA2、1101.69±1.87。P=0.0110t。5．LEV430.8%1123VPA861.5%11362118。3P=0.2379。、BECT3～13465%15。6BECTLoiseau714～16。50%15.4%80%＞2。2007VPA8ⅠⅡ9。LEV2007。LEVIQ3。VPA1VPA110VPAFIQ1.69LEVLEV。VPA1112LEV。LEVVPAVPA。BECT。1．．2006326-334．2ArifHBuchsbaumRPierroJetal．Comparativeeffectivenessof10antiepilepticdrugsinolderadultswithepilepsy．ArchNeurol201067408-415．3TedrusGMFonsecaLCCastilhoDPetal．Benignchildhoodepilepsywithcentro-temporalspikesEvolutiveclinicalcognitiveandEEGas-pects．ArqNeuropsiquiatr201068550-555．4．．200015432-434．5．．20024205-206．6．J/CD．201041190-1192．7LoiseauPDuchéBCordovaSetal．Prognosisofbenignchildhoodepilepsywithcentrotemporalspikesafollow-upstudyof168patients．Epilepsia198829229-235．8WhelessJWClarkeDFArzimanoglouAetal．TreatmentofpediatricepilepsyEuropeanexpertopinion2007．EpilepticDisorder20079353-412．9GlauserTBen-MenachemEBourgeoisBetal．ILAEtreatmentguidelinesevidence-basedanalysisofantiepilepticdrugefficacyandeffectivenessasinitialmonotherapyforepilepticseizuresandsyn-dromes．Epilepsia2006471094-1120．10FonsecaLCTedrusGMPachecoEMCetal．Benignchildhoodepi-lepsywithcentro-temporalspikesCorrelationbetweenclinicalcogni-tiveandEEGaspects．ArqNeuropsiquiatr200765569-575．11．J/CD．200931174-1179．2011-09-05．J/CD．2012661572-1573．·3751·2012366ChinJCliniciansElectronicEditionMarch152012Vol．6No．6