阿特拉津在水环境中的残留及其毒理效应研究进展

:,,1982,,#*(No.30170162);(No.CL045001)阿特拉津在水环境中的残留及其毒理效应研究进展*孟顺龙胡庚东瞿建宏吴伟陈家长#(,,214081),,,,(),ResearchprogressonatrazineresidueinwaterenvironmentanditstoxicologicaleffectsMengShunlong,HuGengdong,QuJianhong,WuWei,ChenJiazhang.(KeyOpenLaboratoryofEcologicalEnvironmentandResourcesofInlandFisheries,FreshwaterFisheriesResearchCenter,ChineseAcademyofFisherySciences,WuxiJiangsu214081)Abstract:AtrazineisoneoftheherbicideswidelyusedinChinaandworldwide.Atpresent,atrazinehasbeenobservedinmanysurfaceandgroundwaters,whichseriouslythreatentheecologicalenvironmentanddrinkingwatersource.Thepapersummariesthestructure,applicationandresidueinwaterenvironmentofatrazineandreviewstheresearchprogressofitsacute,physiologicalbiochemicalandgenetictoxicities.Finally,moredirectionssuchascarcinogenesis,teratogenesis,mutagenesis,procreatetoxicity,cumulativetoxicityandtoxicitymechanismofatrazinearesuggestedtomakeanintensivestudy.Keywords:atrazine;waterenvironment;residue;toxicologicaleffects,2461,3,5,C8H14ClN5,1952Geigy,1958,(LD50)1750mg/kg;LD503080mg/kg;(Ranalimnocharis)48h(LC50)53.0mg/L[1];(Palaemonetespugio)96hLC509.0mg/L[2];96hLC504.5~100.0mg/L[3,4],,[5]1071,[6][7]119592080,19961800t,19982130t,19992205t,20002835.2t[8],20%20015000t[9],,19801990,29840t[10],60%1965,1750t,30[11]1986,120t[12]1050,2,pH5~9,30d,,150~180d[13]2056431620096/,[14],0.1~30.3g/L[15]MARTIN[16]Yamaska5,(2g/kg)BUSTER[12]1052105418,,4g/L,,,,,,,,[17][18],,;130m(DEA)7.2g/L;DEA(DIA)()6~10,,,0.67~3.90g/L[19][13]205208,GIS,,,9.7108.854g/L,;7,18.93g/L;,,[20]20031120049,4,,21.3~613.9ng/L,20044,200311,(3g/L),,[21],,101.1~64490.0ng/L,100%33.1生理生化毒性研究3.1.1,,,,,,,,,,[22,23],[24],1997(WWF),[25]DUNKELBERG[26]S()5a,,,,,[27][28],,,;,,(P0.01)[5]10701072,,1.0mg/L,,84.1%,(P0.01),,,HAYES[29],,650.1g/L;,0.1g/L,20%HAYESaromatase,,;aromatase,SANDERSON[30],CYP19,3.1.2,,,(LPO),,,,,,(CAT)(SOD)(GSTs)(GSHPx)(GSH),,DNA,,,[31],P450N,GSTsGSH;GSTs[32]ELIA[33],GSH(GSSG)(GPxs)SOD,(G)(G)GST;,GSH/GSSG;GSH/GSSG,[34](Ranadaunchina),SODCATGSHPx,20mg/L,,,(0.1~10.0mg/L)SOD[35]GSTs[36],SODGSTs,3.1.3,,FISCHER[37],,,;,,,(Onchorynchusmykiss)[38],5g/L[39](Salvelinusfontinalis)120g/L,[40][41],20010010mg,,()(),;ROSES[42]10d0.1mg/L,,[43]MANSKE[44],,STEINBERG[45](Brachydaniorerio)5g/L,,1,[46],50g/L,,66316200963.2遗传毒性研究(),,,,(),,[47][48](Ranaadenopleura)0.010.101.0010.00mg/L,14d,(P0.05),,[49]MORGAN[50],33mg/L,100mg/L;8mg/L,126mg/L[51]Ames,(438mg/kg),(P0.05),,Ames,(P0.05),RUIZ[52]THOMAS[53],[54],3mg/L48h,[55,56]VAN[57],0.05~0.65g/L,95%DONNA66,44,,16%[58](P0.05),,,DNA,4,,,(),,,:[1].[J].,1990,25(1):3234.[2]WARDGS,BALLANTINEL.Acuteandchronictoxicityofatrazinetoestuarinefauna[J].Estuaries,1985,8(1):2227.[3]SAGLIOP,TRIJASSES.Behavioralresponsestoatrazineanddiuroningoldfish[J].Arch.Environ.Contam.Toxicol.,1998,35(3):484491.[4],,.[J].,2007,29(4):254256,260.[5],,,.[J].,2007,26(7).[6]GRAYMOREM,STAGNITTIF,ALLINSONG.Impactsofatrazineinaquaticecosystems[J].EnvironmentInternational,2001,26(7/8):483495.[7]HOPENHAYNRC,STUMPML,BROWNINGSR.RegionalassessmentofatrazineexposureandincidenceofbreastandovariancancersinKentucky[J].ArchivesofEnvironmentalContaminationandToxicology,2002,42(1):127136.[8]SINTEINB.EvaluatingtheenvironmentalfateofatrazineinFrance[J].Chemosphere,1996,32(12):24412456.[9]RENJ,JIANGK.ImpactofatrazinedisposalonthewaterresourcesoftheYangRiverinZhangjiakouareainChina[J].BulletinofEnvironmentalContaminationandToxicology,2002,68(6):893900.[10]GIANESSILP.Lackofdatastymecsinformeddecisionsonagriculturalpesticides[J].Resources,1987,89(1):14.[11],,,.[J].,2002,13(5):625628.[12]BUSTERHR.AtrazineandotherstrazineherbicidesinlakesandrainsinSwitzerland[J].Environ.Sci.Technol.,1990,24(7).[13],,.Atrazine[J].,2005,26(3).[14]SIEBERSJ.PesticidesinprecipitationinnorthernGermany[J].Chemosphere,1994,8(8):15591570.[15]HEMILTONPB,JACSONGS,KAUSHIKNK,etal.Theimpactofatrazineonlackperiphytoncommunities,including67carbonuptakedynamicsusingtrackautoradiography[J].Environ.Pollut.,1987,46(2):83103.[16]MARTINM,HAGEGEA.Useofsynergisticextractionforthestudyofatrazine/metalinteractions[J].AnalyticaChimicaActa,1998,373(2):161165.[17],,,.[J].,2001,22(2):6973.[18],.[J].,2002,47(10):758762.[19],,.[J].,2002,23(1):126128.[20],,,.[J].,2005,27(8):634636.[21],,,.[J].,2006,25(3):375376.[22],,,.[J].,2000(4):3238.[23],.[J].,2000,13(2):135144.[24],.[J].,2001,22(2):2325.[25]KORNILOVSKAYSIN,GORELAYSMV,USENKOVS,etal.Histologicalstudiesofatrazinetoxicityonthethyroudglandinrats[J].Biomed.Environ.Sci.,1996,9(1):6066.[26]DUNKELBERGH,FUCHSJ,HENGSTLERJG,etal.Genotoxiceffectsofherbicidealachlor,atrazine,pendimethalineandsimazineinmammaliancells[J].Bull.Environ.Contam.Toxico1.,1994,52(4):498504.[27]PODDAMV,DERIUF,SOLINASA,etal.Efectofatrazineadministrationonspontaneousandevokedcerebellaractivityinrat[J].PharmacologicalResearch,1997,36(3):199202.[28],,,.(E2)[J].,2003,34(2):110112.[29]HAYESTB,COLLINSA,LEEM,etal.Hermaphroditic,demasculinizedfrogsafterexposuretotheherbicideatrazineatlowecologicallyrelevantdoses[J].PANS,2002,99(8):54765480.[30]SANDERSONJT,SEINENW,GIESYJP,etal.