门静脉高压脾亢术后应用重组人生长激素的临床意义

(r2hGH),r2hGH30,30(POFS)17(5616%),2(616%),(P0101)27(90%),18(60%),(P0101)1POFS,ApplicationpostoperativelyofgrowthhormoneinpatientswithhypersplenismduetoportalhypertensionZHUWeiqun.DepartmentofGeneralSurgery,GuangzhouEighthPeoplesHospital,Guangdong,510060,ChinaAbstractObjectiveTodiscusstheeffectsofrecombinanthumangrowthhormoneonpostperativepatientswithhypersplenismduetoportalhypertension.MethodsAprospective,randomizedandcontrolledtrialwascarriedout.Theexperimentalgroupcomposedof30casesandthecontrolgroupcomposedof30cases.Thepostoperativefa2tiguesyndrome,infectionofabdominalcavityandwoundhealingwereobserved.ResultsThepercentageofpatientswithoutpostoperativefatiguesyndromewas56.6%inexperimentalgroupand6.6%incontrolgroup(P0.01).Thefirstclassofwoundhealingwas90%inexperimentalgroupand60%incontrolgroup(P0.01).Therewasnosignificantdifferencesbetweenthetwogroupswithinfectionofabdominalcavity.ConclusionTherecombinanthumangrouphormoneareusefulinimprovingpostoperativefatiguesyndromeandwoundhealing.KeywordsDevascularizationNutritionalsupportGrowthhormone1985(r2hGH),r2hGH1:51006011160()30,25,5;51,30,38;Child2pugh,A4,B20,C630,24,6;50,28,36;Child2pugh,A7,B18,C5+,MED,116cm,:,CX;MED;,,,,,,2;MED,[2]659318%,[3]1379314%,[4]72,8,MED,,32MED1/3,9618%,1112,:,1998:3113122,,,11,1999,19(8):4604623,,,11,2001,11(5):2662684,,,1MED1,2002,5(1):5758(2003209224)0792003101010ChineseJournalofPrimaryMedicineandPharmacy,October2003,Vol.10,No.10112()48h,4IU,,1,7d1113POFSChristensenB114SASSystem2Christensen(1),2,31112,,35,68,,910,217(5616)10(3313)2(616)1(313)2(616)2(616)17(5616)9(3010)21713326167171337168P0101010101010101327(9010)2(616)1(313)18(6010)10(3313)2(616)2712061670135P0101010101053,,,,,,,,,[1],(POFS)POFS[2]r2hGH17(5616%)2(616%),(P0101)17(5616%)9(30%)2(616%)1(313%),(P0101)r2hGH,,r2hGHIGF2,,,[3],,,,r2hGHPOFSPOFS,r2hGHmRNA,[4],(90%)(60%),(P0101),,(P0101),Belcher:6d,GH[5]:,r2hGH,,:,[6]1SalmonP,HallG.Atheoryofpostoperativefatigue.JRSocMed,1997,90(12):6616642SalmonP,HallG.Atheoryofpostoperativefatigue:aninterationofbiological,psychologicalandsocialprocesses.PharmacolBichemBe2hav,1997,56(4):6236283JacksonNC,CarrolPV,RussellDL,etal.Effectofglutaminesupplemention,GHandIGF2onglutaminemetabolismincriticallyillpa2tients.AmJPhysiolEndocrinalMetab,2000,278(2):2262334DonaghyA,RossR,WicksC,etal.Growthhormonetherapyinpa2tientswithcirrhosis:Apilotstudyofefficacyandsafety.Gastroen2terology,1997,113:16175BelcherH,EllisH.Somatropinandwoundhealingafterinjury.JClinEndocrinolMetab,1990,70:9399436,11:11:,2001:210234(2003206203)1792003101010ChineseJournalofPrimaryMedicineandPharmacy,October2003,Vol.10,No.10