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30420118ChineseJournalofBiomedicalEngineeringVol．30No．4August2011doi10．3969/j．issn．0258-8021．2011．04．0052010-12-012011-05-03*。E-mailliqiao@sdu．edu．cn12111*12500122250031。MIMIC。5mmHg。。R318.08A0258-8021201104-0509-05ResearchonArterialBloodPressureEstimationUsingPulseWaveTransitTimeMENGXiang-Ping1LIUBing2DENGBao-Yun1PANYan1LIQiao1*1InstituteofBiomedicalEngineeringShandongUniversitySchoolofMedicineJinan250012China2DepartmentofCardiologyJinanFourthHospitalJinan250031ChinaAbstractThisstudyaimedtodescriberelationshipsbetweenthearterialbloodpressureABPandpulsewavetransittimePWTTanddiscussthereliabilityofABPestimationusingPWTT．UsingMIMICdatabaseofferedbyMassachusettsInstituteofTechnologyMITwecalculatedPWTTfromECGandPhotoplethysmography．MeanwhilemeanbloodpressureMBPwasacquiredfrominvasiveABP．LinearregressmethodwasusedtoderivetheequationofPWTTandMBP．ThentheestimationofMBPwascalculatedthroughtheequationandwascomparedwiththerealvalueforassessment．ExperimentalresultsshowedthattherewasanegativecorrelationbetweenPWTTandMBP．MBPcanbeestimatedbyPWTTwithinaspecificperiodandrootweansquareerrorwaslessthan5mmHg．Themethodwasappliedtoanalizeclinicaldataandshowedavailabletoestimatearterialbloodpressure．KeywordsarterialbloodpressurepulsewavetransittimelinearregressarterialbloodpressureABP。“”。。pulsewavevelocityPWVpulsewavetransittimePWTT、、。1957LansdownPWTTABP1。PWTT2。PWTTABP。30PWTTABP24h3－7。Physionethttp//．physionet．org/MIMIC8PWTTPWTT。11.1。。6。。BPPWTTBP=a+b×PWTT1ab。ab。1.2MIMICMIMICHewlettPackardCMSMerlin72ECG、ABP、PhotoplethysmographyPleth、40h。MIMICECG、ABPPleth582161.7h37.3h/。PWTTQRSQRSPleth。Pleth、PWTT59Pleth。MBPABPSBPDBPMBP=DBP+SBP－DBP/3。珔μ±2σ。。1210000/35000/42500/。PWTTMBPPWTT。2MBPPWTT1211。1珔μ±σTab．1Comparisonofdifferentdataprocessingmethods珔μ±σ/mmHg/mmHg/mmHg/mmHg589.17±4.149.14±4.108.92±4.098.88±4.132、PWTTMBPrPWTTrBP。rBP。122500/212。、PWTT。2500/。01542珔μ±σTab．2Comparisonofdifferentdatasegmentations珔μ±σ10000/5000/2500//mmHg8.88±4.136.51±1.695.16±1.374.59±1.27rPWTT－0.28±0.37－0.36±0.18－0.38±0.18－0.35±0.19rBP0.34±0.290.65±0.190.74±0.140.79±0.1312500/。ab2000Fig．1Arterialbloodpressureestimationusing2500heartbeatspersegment．asynchronouscomparisonbenlargeandoverlapcomparisonofthefirst2000beats585Pleth5.42±2.34mmHg5.15±2.42mmHg。ICU10、553。PWTT2.72±1.57mmHg5mmHg。3。2。ab2000Fig．2Arterialbloodpressureestimationusingallheartbeatsasasegment．asynchronouscomparisonbenlargeandoverlapcomparisonofthefirst2000beats3Tab．3Arterialbloodpressureestimationusingclinicalsynchronoussamplingdata/mmHg1112_01565.161112_02665.101112_03394.591115_02321.781115_03481.841124_01361.391124_02441.661125_01371.641125_02322.361215_01461.69珔μ±σ2.72±1.57115303。abFig．3Arterialbloodpressureestimationusingsynchronoussamplingdata．asynchronouscomparisonboverlapcomparison3、。。。、。2。24h、、PWTT。。5%6。5%87.6%5%85%9。Chua±6mmHg±4mmHg3。Wong6.6mmHg4.3mmHg4。。2500/3.89±1.08mmHg。。。、。PWTTPWTT10。。。30mmHg。PWTTPWTT11PWTT。2154。。PWTT。。4MIMIC582161.7h。5mmHg。10。PWTTPWTT。1LandowneM．AMethodUsingInducedWavestoStudyPressurePropagationinHumanArteriesJ．CirculationResearch19575594－601．2．J．199514188－93．3ChuaCPHeneghanC．ContinuousBloodPressureMonitoringusingECGandFingerPhotoplethysmogramA．InProceedingsofthe28thIEEEEMBSAnnualInternationalConferenceC．NewYork2006351175120．4WongMYMZhangYuanting．TheRelationshipbetweenPulseTransitTimeandSystolicBloodPressureonIndividualSubjectsafterExercisesA．InProceedingsofthe1stDistributedDiagnosisandHomeHealthcareD2H2ConferenceC．ArlingtonVirginiaUSA2006437－38．5SharirTMarmorATingCTetal．ValidationofamethodfornoninvasivemeasurementofcentralarterialpressureJ．Hypertension19932174－82．6．J．200627219－21．7．J．20092611020－1021．8MoodyGBMarkRG．ADatabasetoSupportDevelopmentandEvaluationofIntelligentIntensiveCareMonitoringA．InComputersinCardiologyC．IndianapolisUSA19969657－660．9．J．2002192217－220．10．D．2005．11．J．200916156－60.315