青霉素设计

内蒙古科技大学本科生毕业设计说明书I年产630吨青霉素发酵工段工艺设计摘要青霉素是由微生物或高等动植物在生活过程中所产生的具有抗病原体或其它活性的一类次级代谢产物，以前被称为抗菌素，以疗效高和毒副作用小成为人类治疗疾病的首选。本设计为年产630吨青霉素工艺设计，包括以下几部分内容：青霉素的背景知识及发酵生产工艺过程的简介；物料衡算和热量衡算；发酵主要设备（种子罐和发酵罐）的计算与选型；环境要求及废物处理和利用。经计算设计采用三级发酵工艺进行青霉素的生产，菌种经一级种子发酵罐扩培后进入二级种子发酵罐再进入发酵罐。各种补加用料以流加的方式加入，保持产黄青霉的健康生长。设计使用7台一级种子罐、3台二级种子罐、9台发酵罐。根据计算故而设计出厂房需要采用三层，在不同楼层放置不同类型的罐体，以满足生产需要,并根据计算结果，设计了六张图纸，分别为发酵罐装配图、一级种子罐装配图、工艺管道及仪表流程图、厂房车间布置图、物料流程图和设备一览表。【关键词】青霉素发酵工艺流程设备选型；内蒙古科技大学本科生毕业设计说明书IITheprocessdesignofthefermertationsectionwiththecapacityof630tonsannuallyAbstractPenicillinisproducedbymicroorganismsorhigheranimalsandplantswhichproduceinthelifeprocessandhastheanti-pathogenorotheractivesecondarymetabolites,formerlyknownasantibiotics,withhighcurativeeffectandlittleside-effectwhichhasbecomehumandiseaseofchoice.Thiswasaprocessdesignaboutthefermentationsectionofpenicillin,whichcanproduces630tonsannually,includesthefollowingcontents:theprocessofbackgroundknowledgeandproductionofpenicillinfermentationprofile;materialbalanceandheatbalance;themainequipmentoffermentation(seedtankandfermentor)ofthecalculationandselection;environmentalrequirementsandwastetreatmentandutilization.Accordingtotheprocess,wedesignedwiththreefermentationprocessforpenicillinproduction,strainthroughseedfermentor,afterexpandingintothesecondseedculturefermentationtankandthenintothefermenter.Forthepenicillin,thevarietyofadditionalmaterialsinordertojointhefed'swayofmaintainingahealthygrowthofpenicilliumchrysogenum.Thisdesignuses7setsaseedtank,3setstwoseedcontainers,9setsfermenter.Fermentationprocessusethreelayerdesign,placementofdifferenttypesoftankindifferentlayers,inordertomeettheneedofproductionAccordingtotheresults,wefinishedallofthesixdrawings,suchasthecutawayviewoffermentor,thecutawayviewofseedpot,theflowchartofprocesspipingandinstrumentation,theflowchartofworkshopcollocation,thematerialflowchartandtheequipmentlist.Keywords:PenicillinFermentProcessEquipmentselection;内蒙古科技大学本科生毕业设计说明书III目录摘要........................................................................................................................................IAbstract.....................................................................................................................................II第一章引言...............................................................................................................................11.1总论................................................................................................................................11.1.1设计依据..............................................................................................................11.1.2指导思想..............................................................................................................11.1.3生产规模..............................................................................................................11.1.4设计范围..............................................................................................................11.2产品综述........................................................................................................................11.2.1青霉素概述..........................................................................................................11.2.2治疗病症..............................................................................................................21.2.3青霉素单位..........................................................................................................2第二章工艺设计说明...............................................................................................................32.1青霉素的生产方............................................................................................................32.2青霉素发酵过程............................................................................................................32.3青霉素生产工艺流程介绍............................................................................................32.3.1菌种的保藏..........................................................................................................32.3.2种子罐和发酵罐的培养工艺..............................................................................32.3.3发酵培养基组成介绍..........................................................................................42.3.4发酵......................................................................................................................42.4青霉素生产工艺流程图................................................................................................5第三章工艺计算.......................................................................................................................63.1主要设计指标................................................................................................................63.2发酵罐容积的确定........................................................................................................63.2.1发酵液体积计算..................................................................................................63.2.2发酵罐公称体积.............................