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11.()(TOAPhraameeuti。aleo.,Ltd)()BIOTHREE,45,、、()。,,(KaorlinskaIsntett)()。:、1.(BIOTH)E3,000mg/kg(),,(LD50)。50,。(BIOTHRE)E。.2,,。,,、()、。、()、,。(B10THE)(elostridiumbutyriel;mTOA)、(BaeillusmesenterieusToA)(Strept。CoeeuSfaeealiST110)。l。3+,3,(BIOTHRE)E。(BIOTH)E,80℃60,()50℃60,70℃60。,,(BIOTHRE)E50、,。.3(BIOTHE)3,(elostridiumbL,tyrie:,。TA)(BaeillusmesenetirCuSTO)A,。(strept。eoCCuSfaeeaiST110)。(BIOTHE),,,、,。33。36。4.,10THREE)(Bae11It,5mesenterieusTOA),、。,,,。(ilase)、(Portease)。,,。(BIOTHE)(StreptoeoeeusfaeealisT110),,。,。,。(BIOTHE)(ClostridiumbutyrieumTOA)、、、、,,。,,,,。,。,,(BIOTHRE)E,,,。(BorTHRE)E3、0157、、、、、、(idfficile)。.5(BIOTHREE)(StreptoeoeeuSfaeealiST110)(BaCillusmesenteriCuSToA),(5.3xlo7/ml),10(52.2x107/ml)。(BIOTHREE)(StreptoeoeeusfaeealisT110)(Clostrdiu。butyriC0T)A,,(8.2x1071),11(9.0x10m/1)。(BIOTHREE)(BaeillusmesenterieusT--OA),,(StreptoeoeeusfaeealisT110)。(B10THE),、(BIOTHRE)E(lCostriidumbuytirculnTA),。3,,、,、、。,。,。,(BIOTHRE)E,,50.6“、”,、,。、。,。(BIOTH)E、,。。、,。,,,。,,。(BIOTHRE)E3,3。,。10TH)E(lPasmid)DNA,DNA,lasmid)DNA。、()CMICMICABP(C)))3.1333NA()))200DMppC()))200NFLX()))2555OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOFLX()))12.555CEX()))200LFLX()))5000CCL()))255555TFLX()))6.2555CCCCCxD()))200ENX()))10000CCCCCXMAX()))200CPFX()))6.2555CCCCCFIX()))1600CX()))200CCCCCFTMIP()))200CCCCCPDXPR()))200200KM()))3200FOM()))2555GM()))1000000CLDM()))3200VCM()))1.566610000PPPPPLB()))B10000:(gm/)l.7(KarolinsakIntsett),2000(B10TH)E,(BIOTH)E。HCA(HeotorcyiclcAmine),DNA(NDAAdduct),HCA。()(BIOTH)EHCANDA(DNAAdduc)t,(BIOTHRE)E。(BIOTHRE)E。(AOM)n,90%。2(BIOTH)E,56.5%。10TH)E。&(Nautralllercell)NK,T、B3,NK,、,,。,,,(INF),NK。NK,,3,7Tc,NK。,NK。10THRE)E3C3H/He,3(P〔c)NK。ET50:l,64.7%,16.7%4。NK29.%9;364.7%,,543.9%;734.9%。(BoITH)E3NK。(BIOTHRE)ESpagrue·Dawley3,,(MLN)A,(BIOTHRE)E。9.(t011likcerccptor)TLR4,,。L)R。TLR,10,,TL4R。TL4RiLpopolysachcde(LPs)(NF)(otkine)。,(BIOTH)E,(BIOTHRE)E,HT296,HT29TL4RmRNA/GAPDHmRNA100%,TLR4mRNA。:.,TL4RmRNA168%。.INFY,TL4RmRNA19118%,,216%。:(BIOTH)ETL4R,(BIOTH)E。10.28,(BIOTH)E()、,,(BIOTH)E。(BorTH)E。(B10TH)E3p0.05。、1.(BIOTHREE)(BacetiralrTansloeation)(BT;BacetiralTarnslociaton),。(B)T,(、)、、。、、、、。,,。::。:。:25,~365~,3~17~100cm13()IVHCRP/DIC,BT~~MRSA、、,~(BIOTH)E~2~2MRSA、、,。:、(B)T,,,(BIOTHRE)E。2.(BIOTHRE)E::5、2、1、1,。(BIOTH)EgZ/,2。:,,。()(BIOTHREE)LO。,`OJIIU`.OQ7.442.862.258.811.930.82BObacter7.573.169.590,9E.Cli8.980.738.720.75(L09SD/g)(BIOTHREE)~~~、、~~~~~~、、~~~、、---、~=erPOStMUaroetal:JPed.Surg.34.273.1999403020100ù\l。aìxoPues3.(B10THREE),(BIOTHRE)E。1,l/10,18,。()4.(IBOTHER)EMSRAMRSA。60MRSA,“”。9,MRSA,,,“”。、(、、)、(、、、)、、。MRSA:、、。MSRA,MRSA,10TH)E。,、(BIOTHRE)E;,、(BIOTHREE)。10(4,6)(BIOTH)E-312,MSRA,:(BOITHRE)EMRSA。WIStar(3009),,,,4MRSA235109Cfu/body,3(latajnoxeif80nIg/kgdayd.1.vx4),(BIOTHREE),。(BIOTHREE)。8,6%0,MRSA,MRSA104.76ofu1。101.76ofu/。1(p0.01),1%2。,104.18Cfu/ml。102.gocfu/ml,,。(lBoTHRE)E,MRSA。4.(IBOTHER)EMRSAMRSA。60MRSA,“”。9,MRSA,,,“”。、(、、)、(、、、)、、。MRSA:、、。MSRA,MRSA,10TH)E。,、(BIOTHRE)E;,、(BIOTHREE)。10(4,6)(BIOTH)E-312,MSRA,:(BOITHRE)EMRSA。WIStar(3009),,,,4MRSA235109Cfu/body,3(latajnoxeif80nIg/kgdayd.1.vx4),(BIOTHREE),。(BIOTHREE)。8,6%0,MRSA,MRSA104.76ofu1。101.76ofu/。1(p0.01),1%2。,104.18Cfu/ml。102.gocfu/ml,,。(lBoTHRE)E,MRSA。J(/)(;)(n34)Pvalue21/1396(5088)(n30)18/1266(3083)17(%44)7(2%0)15(5)6(2%0)0.71.01.0(,,)197475(310)170460(270)0.08(mL,,)CombinedmajorhePatetComy..2..…….””””_.,,”,_”…,_”””“””,,,5003780(900)30--04700(835)0.33(9%)0(0%)Combinedvaseularr6seetion9(26%)6(20%)(BIOTHRE)E343018753%23%p0.02222419p.00444(1191)(110)))73ns()))(BIOTHRE)E。6.(BIOTHRE)E(UC),、,、,。:(BIOTHRE)E、:、20(BIOTHRE)E,4,9。(BIOTHRE)E,CDA)I;-TRFLP,(BIOTHRE)E。:(UCDAIZ)45%,CD1A3)10%40%,5%-TLP,,(BIOTHRE)E。UCDAsIocerpvalue“’,+“”583.46#(n=11)“”+“”6.222391.911.20.00546.89.980.38567.10THRE)E、10(85),BIOTHREEZ,14()、21、28(after14days),、,l、3。,;、;、、;、、、pH;、、、。、(B10THRE)E(1BS)(1BD,,rChon’S)·()