肌醇生产工艺进展_石起增

[e-mail]11111191D-myo-11B11122112:33130200013600116009011131123.121222122xy5MeKNa3.1.12221CONH22Na2SO4NaCl22CaO1C6H12O6CaOpH67NaOHpH810CaO43.1.222111.52.5MPa21162119.50.81.2MPa1685225151.2MPa18.59pH6761140215.5w/w34h11321423.1.311.11.281.30506025301173.211817170.511201.5MPa78h1HPLC99.31.34921023.311105565w/w13015034h963.41Ca2Mg2SO42ClPO43pH7.08.0SO42Ca21111,6-β-1Ca2Mg2HPLC112110.5μm141311333-3EC3.1.3.86-3EC3.1.3.26pH333pH2.56.04.1333314334.211521156FL40120.5pH65020h2168163-3pH5.155595173-3EC3.1.3.2pH5.55535.7u/ml0.533u/ml22h20min0.1MPa2110.313.54.33318-32-Ralf19,20HPIC32131pH31211Ins1,4,5P322512316--6--D-myo-11600kg61211127112111PlattnerR,IrvinBJ,GuoS,etal.AnewlinkbetweentheC-Ab1tyrosinekinaseandphosphoinositidesignallingthroughPLC-gramm1J.NatCellBiol,2003,54:309-319.CavazzaC.Carnitineandinositolphosphate-containingcompositionusefulasdietarysupplementordrugP.WO:2000064426A2,2000-11-02.CA2000,133:340235gKikuchiH,TamuraM.ManufactureofinositolfromsugarbeetsugarusingyeastP.JP:2000236890A2,2000-09-05.CA2000,133:192138k.J.,2000,3:31-33..J.,2002,5:26-28.,.P.CN:1075135,1993-08-11.CA1994,120:192213n.J.,1999,5:7-8.,,,.J.,1998,3911:583-585.,.J.,2003,5:13-15.,,.12345678910J.,1998,3910:520-522.,,.β-J.,2001,172:105-108..P.CN:1159441,1997-09-17.CA2000,132:69387t,.J.,2002,333:151-154.PandeyA,SzakacsG,SoccolCR,etal.Production,purifica-tionandpropertiesofmicrobialphytasesJ.BioresourTechnol,2001,773:203-214.,,,.J.,1997,185:48.,.J.,1998,235:56-58.,,,.J.,1998,2:15-19.,.J.,1999,294:12-14.GreinerR,CarlssonNG,AlmingerML.Stereopecificityofmyo-inositolhexakisphosphospHatedephosphorylationbyaphytate-degradingenzymeofEscherichiacoliJ.JBiotechnol,2000,84:53-62.GreinerR,AlmingerML,CarlssonN-R.Stereospecificityofmyo-inisitolhexakis-phosphatedephosphorylationbyaphytate-degradingenzymeofBaker’syeastJ.JAgricFoodChem,2001,495:2228-2233.GreinerR,AlmingerML,CarlssonN-R,etal.Pathwayofdephosphorylationofmyo-inositolhexakisphosphatebyphytasesoflegumeseedsJ.JAgricFoodChem,2002,5023:6865-6870.Irvine,RobinF.20yearsofIns1,4,5P3,and40yearsbeforeJ.NatRevMolCellBiol,2003,47:586-590..-J.,2001,4:29-30.11121314151617181920212223ProgressofInositolManufatureProcessSHIQi-Zeng,LIUQiao-Ru,DONGWen-Ju,YANGJian-MaoCollegeofChemicalandEnvironmentalScience,KeyLab.ofControllingEnvironmentalPollutionofHenanProvince,HenanNormalUniversity,Xinxiang453007Theinositolismainlyproducedbymeansofchemicalandenzymatichydrolysisofphytateunderdifferentreactionconditions.Progressofmanufactureprocessofinositolisdiscussed.D-myo-inositol;phytin;phyticacid;phytase;hydrolysis;process