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内蒙古科技大学本科生毕业设计说明书题目：年产2300吨青霉素发酵工段工艺设计学生姓名：陈浩学号：0602149136专业：生物技术班级：生物技术06-1班指导教师：陈飞雪赵宏宇内蒙古科技大学毕业设计说明书I年产2300吨青霉素发酵工段工艺设计摘要本设计以注射用青霉素G为背景，来进行年产2300吨青霉素发酵工段工艺的设计,考虑到为了实现菌种放大的平稳过渡，设计采用三级发酵工艺进行青霉素的生产，菌种经种子发酵罐扩培后进入二级种子发酵罐再进入发酵罐。各种补加用料以流加的方式加入，保持产黄青霉的健康生长。设计使用4台一级种子罐、7台二级种子罐、14台发酵罐。厂房采用三层设计，在不同层放置不同类型的罐体，以满足生产需要，在厂房内部设置吊装孔，用以上吊原料。在本设计中充分考虑了理论设计量的合理性，又兼顾了实际生产的可行性的情况下对物料、能量以及发酵控制因素等进行了的计算，就发酵后期所涉及的一系列问题详细说明了其解决方法，力求设计的完整性及准确无误。关键词：青霉素；发酵；批量；工艺；生产内蒙古科技大学毕业设计说明书IISectionofanannualoutputof2,300tonsofpenicillinfermentationprocessdesignAbstractThedesigninjectionofpenicillinGasbackground,tocarryoutanannualoutputof2300tonspenicillinfermentationsectioninthedesignprocess,takingintoaccountthestrainamplificationtoachieveasmoothtransition,designedwiththreefermentationprocessforpenicillinproduction,strainthroughseedfermentor,afterexpandingintothesecondseedculturefermentationtankandthenintothefermenter.VarietyofadditionalmaterialsinordertojointheFed'swayofmaintainingahealthygrowthofPenicilliumchrysogenum.Designuses4setsaseedtank,7setstwoseedcontainers,14setsfermenter.Plantathree-tierdesign,placedindifferentlayersofdifferenttypesoftanks,tomeetproductionneeds,setintheplantandliftingholesforhangingmaterial.Fullyconsideredinthedesignofareasonableamountoftheoreticaldesign,butalsothefeasibilityoftakingintoaccounttheactualsituationofproductionofmaterials,energyandfermentationcontrolfactorsforthecalculation,onthefermentationofarangeofissuesinvolvedinthelatedetailsitssolution,andstrivetodesignintegrityandaccurac.Keywords:Penicillin;fermentation;volume;process;production内蒙古科技大学毕业设计说明书III目录摘要.........................................................................................................................................IAbstract......................................................................................................................................II第一章引言............................................................................................................................11.1总论.............................................................................................................................11.1.1设计依据..........................................................................................................11.1.2指导思想..........................................................................................................11.1.3设计要求..........................................................................................................11.1.4设计步骤..........................................................................................................11.2青霉素的发现.............................................................................................................21.3青霉素分子结构及分类.............................................................................................31.4青霉素的单位.............................................................................................................41.5作用机理.....................................................................................................................41.6青霉素的应用.............................................................................................................51.7产品名称及生产规模.................................................................................................51.8产品药理.....................................................................................................................6第二章设计说明......................................................................................................................72.1青霉素发酵过程.........................................................................................................72.2生产方法.....................................................................................................................82.3工艺流程.....................................................................................................................92.4工艺特点...................................................................................................................102.5发酵过程中各参数的相互关系...............................................................................122.6设备框图...................................................................................................................12第三章工艺条件计算............................................................................................................133.1发酵罐设计技术指标...............................................................................................133.2物料衡算...................................................................................................................133.3能量衡算...................................................................................................................173.3.1水....................................................................................................................173.3.2蒸汽..............................................................................................................183.3.3电....................