干扰素产品现状及市场前景

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97(),,[1],,,,,,(12a2b)(HuIFN2)(HuIFN2)[2]1111:,,99%1%,15(n):,,,,,,112:1975Bechenchan.Weollcome,Namalwa,,,95%22(Wellferon,),80%20%113:1972Billian,,,,,:,114:,T()115:DNA:,mRNAcDNA,DNA,,DNA,,1979,Taniguchi[3]1980,NagataDNA22[4]1982Goed2delcDNA1982419974147819831,1992(PCR)IFN21,IFN21[5]IFN212FDA2(1-3)1FDA()()Altimmuneinterferougamma21bGenentech(S.SanFrancisco)(199012)AcferonNinterferonalfa2n3(injection)InterferonScience(NewBrunswick,NJ)(198910)Betaseronrecombinantinterferonbeta21bBerlexlaborratories(wayne,NJ)chiron(Emeryville,CA),(19937)IntronAinterferonalfa22b(recombinant)Schering2ploughMadison,NJ)(19866)(19886)AIDSKaposis(198811)(19912)(19927)Roferon2Ainterferonalfa22arecombinantHoffmann2LaRoche(Nutley,NJ)(19866)AIDSKaposis(198811)3Interferonbeta2laAvohexBiogen(MS)(199512)2FDA()ActimmuneIFN21bGenentech(S.SanFrancisco,CA)AlferonLD0IFN2n3InterferonSciences(NewBrunswick,NJ)ARC,AIDS/AlferonNGelIFN2n3InterferonSciemes(NewBrunswick,NJ),5199741478AlferonNinjectionIFN2n3Interferonsciences(NewBrunswick,NJ)walterReedArmyInstituteofResearch(Washington,DC)HIVInterferonSciences(NewBrunswick,NJ),AIDSKa2posis,HIVBetaseronrecombinantIFN21bBerlexlaboratories(wayne,NJ)IntronAIFN22b(recombinant)Schering2Plough(Madison,NJ),CML,Hodgkins,CrohnsHIVVIDEXHIVREBIFrecombinantIFNSeronoLaboratories(Norwell,MA)/recombinantIFN2Biogen(cambridge,MA)Referon2AIFN22recombinantHoffmann2LaRoche(Nutley,NJ)CML12:3Scrip1996,5,24;NO.213219ANG,1995GENETICENGINEERINGNEWS31b()198919891b1992199219922a199219922b199719943311:,17,2[6]312:,,,6199741478,,[7],2313:,,,2,314:,,,()[8],212,,HIV315:2(),1,,14411:E,,,,,412:Kaposis,,80%48%,[1]FNA413,414(IFN22aIFN22bIFN21b)[2]IFN21b:(1),IFN21bIFN22a2b(2)IFN21,2,,,,IFN22a2019%,IFN22b619%(3)IFN21MHC(4)IFN21415,,[11],[10]416:,,,;,,,,[11],,,,,,,,,51986FDA22a-2b7199741478,,1988,,44()IntronArIFN22bSegreing2PloughwellfreonHuIFN2nWellcomeRofreon2ArIFN22aHoffmann2LarocherIFN22brIFN22bSINOGENErIFN21rIFN21rIFN22arIFN22arIFN22bHuIFN2n3:1996,Schering2Plough(rIFN22b)HoffmannLaRoche(rIFN22a)1b,:,,;(OTC);30,,,,,,,,(),,,(OTC),,,40,,198920,13,(3)8199741478,515,;,,,,6,:();,[6];,;103-108,;,,;,,;,[1]SuzukiH,Recentadvancesinabzymestudies.JBiochem.1994;115623[2]BaldwinE,PGSchultz.Generationofacatalyticantibodybysitedirectedmutagenesis.Science.1989;2451104[3]TawfikDS,ZemelRZ,Arad2YellimR,etal.Simplemethodforselectingcatalyticmonoclonalantibodiesthatexhibitturnoverandspecificity.Biochemistry.1990;299916[4]HilvertDH,HillKW,NaredKD,etal.AntibodycatalysisofaDielsAlderreaction.JAmChemSoc.1989;1119261[5]JandaKD,WeinhouseMI,SchloederDM,etal.Baitandswitchstrategyforobtainingcatalyticantibodieswithacyl2transfercapabilities.JAmChemSoc,1990;1121274[6]StephensDB,IversonBL.Catalyticpolyclonalantibodies.BiochemBiophysRcsComm,1993;1921439(8),1996200010%,,2000,3900,5200055,50,,,200013,600-800,(,,),1996-20001500,2000-2010,7000,()21[1],[2],,199316(4)[3]TTanignlietalDrocJapAcall,197955.serb464.[4]SNagataetal.Nature,1980;284316[5],,1992,8(2)[6],,1995;15(4)158[7],,1994;15(5)265[8]DAEpsteinPharmInt,1986;7(8)195[9]BiotecholNews1994;14(25)1-2[10]177(6)448[11],,19965(1)3199741478

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