雌激素受体

·590·040590-05αβαqααββ·591·αβαααααβαααβαβγααααααqα·592·ααi——αααα——α——βακ——κ——ααi·593·α————òαqααβααββαββααββαα·594·αββαββγ-1630AdvanceinstudyofestrogenreceptorChun-XiaMei1,Ji-QiangZhang21Company11,ThirdMilitaryMedicalUniversity,Chongqing400038,China2DepartmentofNeurobiology,ThirdMilitaryMedicalUniversity,Chongqing400038,ChinaAbstractEstrogenreceptorscanbeclassifiedasclassicnuclearreceptorsandnovelnon-classicmembranousreceptors.Theformerincludesthewell-knownα(ERα)andβ(ERβ)subtypes,whicharelocatedincellnucleusandmediategenomiceffectsofestrogenbyregulatingthetranscriptionofspecifictargetgenes.Themembranousreceptors,includingGprotein-coupledreceptor30(GPER1,alsocalledGPR30),Gαq-ERandER-Xandtheextra-nuclearcomponentsoftheclassicalERs,wereidentifiedinrecentyearsanditseemsthatsomeofthemonlyfunctioninspecificbrainregions.Thesemembranousreceptorsmediaterapidnon-genomicactionsbyinteractionwiththesecondmessagecascade.AlltheseERshavebeenidentifiedandfunctionindifferentorgansinacell/tissue-dependentmanner.Keywordsestrogen;nuclearestrogenreceptor;membranousestrogenreceptor