川芎的化学成分及药理作用研究进展

PharmacyandClinicsofChineseMateriaMedica2013;4(3)201015116409.21%LigusticumchuanxiongHort.[1]1011.11%CO2[]R282[]A[]1674-926X(2013)03-017-05AdvancementsintheChemicalconstituentsandpharmacologicaleffectsofChuanxiong/JINYu-qing,HONGYuan-lin,LIJian-rui,LIXi,WANGXiao-xiao,LuGuang-hua//(PharmacyCollege,ChengduUniversityofTraditionalChineseMedicine;TheMinistryofEducationKeyLaboratoryofStandardizationofChineseHerbalMedicine;StateKeyLaboratoryBreedingBaseofSystematicResearch,DevelopmentandUtilizationofChineseMedicineResources,Chengdu611137,China)[Abstract]Chuanxiong(ChuanxiongRhizoma,CX),iswidelyusedinChinesemateriamedicato“Promotingbloodcirculationandremovingbloodstasis”.LiteraturesshowthatCXcontainsvolatileoilbelongtothetypesofphthalidewithitsdimer,alkaloid,organicacidandpolysaccharide,etc.ThepharmacologicaleffectsofCX,itsmainchemicalfractionandmonomerarerelatedtomultiplesystems,suchascardiovascularsystem,nervoussystemandrespiratorysystem,etc.Themainbioactivitiesareincludedasimprovingvascularendothelialfunctionandcoronaryflow,decreasingresistanceofbloodflowandbloodpressure,anti-oxygenfreeradical,anti-inflammatory,anti-tumor,inhibitingplateletaggregationandthrombosis,nerveprotectiveeffectandsoon.ThisreviewsummarizestheresearchprogressonthechemicalconstituentsandpharmacologicaleffectsofCXintherecent10years,andsuggeststhatthepharmacologicalstudyonCXextractionandchemicalfractionshouldbestrengthened.ThisreviewprovidesusefulinformationfortheclinicalusesofCXandthedevelopmentofnewproducts.[Keywords]Chuanxiong;chemicalconstituents;pharmacologicaleffects;literaturereview[]2010-08[]611137[]1986-Tel:[phone]Email:[e-mail][]Tel:[phone]Email:[e-mail][]2013-01-20PharmacyandClinicsofChineseMateriaMedica2013;4(3)GC-MSLC-MS601.1.1z-(z-ligustilide)butylphthalidebutylidenephthalide4--3-senkyunolideAsenkyunolideAIsenkyrunolideIFsenkyunolideFneocnidilide3’,6,8’,3a-3’,6,8’,3a-diligustilideZ,Z-6,6’,7,3’a-Z,Z-6,6’,7,3’a-diligustilideZ-6,8’7,3’-(Z-6,8’7,3’-diligustilide)[2~6]1.1.26--1,4-6-butyl-1,4-cycloheptadiene(eudesma-4,11-dlene)3-3-careneterpinene3,7,7--11-[5,5]+-2-(377-trimethyl-11-methylene–spiro[5,5]undec-2-ene)limonene(cubebene)5,5--[6,3,0]-1,7--3-(5,5-dimethyl-bicyclo[6,3,0]undeca-1,7-dien-3-one(xiongterpene[2,3,6]1.1.3ferulicacidcaffeicacidsinapicacidsuccinicacidpalmiticacidpalmiticacidmethylesterpalmiticacidethylesterheptadecanoicacidoleicacid9,12-octadecadienoicacid9,12-octadecadienoicacidmethylester9,12-octadecadienoicacidethylester[2,5~7]1.2tetramethylrazineperlolyrine[8~12][8,9,13,14]0.12~6240μgg-11μgg-1[15~17]1.35.71%DEAE-LCXP-1LCXP-2LCXP-3LCXP-1LCXP-2LCXP-3[18]2“”A/2.12.1.1“”-[19]-[20][21]()[22]BaxPharmacyandClinicsofChineseMateriaMedica2013;4(3)mRNACIRBaxmRNA[23]-Bcl-2[20][24][25]2.1.2,[26][27][28][29]Fas/FasL[30](ERK-1)mRNA[31]AngκB11[32][33]2.1.3Bcl-2Caspase-3Caspase[34][35]A[36]AngVSMC(PDGF-B)PDGF-B[37]2.22.2.1“”[38][39]I2A2[40]2.2.2-2[41](cGMP)Bcl-2[42]2.32.3.1T-betmRNAGA-TA-3mRNAThl/Th2[43]-4PharmacyandClinicsofChineseMateriaMedica2013;4(3)-13[44]2.3.2(COPD)COPDCOPD[45]2.42.4.1[46]2.4.2AGEsBc1-2Bax[47]SnoN-β1SnoN[48]2.52.5.1[49](BMSCs)ca2+BMSCs[50]2.5.2[51][52]2.5.3COC1/DDPCOC1/DDPGSH/GST[53]A549A549HIF-letmRNAHS766T,()“”[][1].(2010)[S].:.[2],,,.[J].,2003,28(6):572.[3],,,.[J].,2007,32(15):1533.[4],,,.[J].,2007,l8(7):1576.[5],,,.[J].,2010,12(3):22.[6],,,.CO2GC-MS[J].,2011,28(8):956.[7],,.-[J].,2004,25(3):150.[8],,,.[J].,1999,34(9):699.[9],,,.HPLC[J].,2005,25(3):278.[10],,,.[J].,2000,13(95):278.[11],.[J].,2007,29(23):2294.[12],.[J].,2004,16(6):3.[13],,.[J].,1996,27(4):213.[14],,.HPLC[J].,2008,11(7):814.[15]YanR,LiSL,ChungHS,etal.Simultaneousquantificationof12bioactivecomponentsofLigusticumchuanxiongHortbyhigh-performaceliquidchromatography[J].JournalofPharmaceuticalandBiomedicalAnalysis,2005,37:87.PharmacyandClinicsofChineseMateriaMedica2013;4(3)[16]YiT,LeungK.SY.,LuGH,etal.SimultaneousqualitativeandquantitativeanalysisofthemajorconstituentsinLigusticumchuanxiongusingHPLC-DAD-MS[J].Chemical&PharmaceuticalBulletin,2006,54:255.[17]ChanSS,LiSL,LinG.Pitfalloftheselectionofchemicalmarkersforthequalitycontrolofmedicinalherbs[J].JournalofFoodandDrugAnalysis.2007,15:365.[18],,,.[J].,2011,29(1):56.[19],,,.[J].,2006,29(11):1196.[20],,.Bcl-2[J].,2010,33(1):82.[21],,.[J].,2006,46(6):32.[22],,.[J].,2008,33(21):2545.[23],,,.BaxmRNA[J].,2011,22(2):435.[24],,,.[J].,2011,24(2):41.[25],.SODNON0SMDA[J].,2011,9(2):212.[26],,,.[J].,2006,26(1):32.[27],,,.[J].,2006,33(7):888.[28],,.[J].,2006,32(4):17.[29],,,.[J].,2011,23(3):408.[30],,,.CVB3[J].,2010,50(4):14.[31],,.1mRNA[J].,2008,22(5):336.[32],,,.1[J].,2006,l4(7):560.[33],,,.[J].,2002,17(5):10.[34],,.Bcl-2Caspase-3[J].,2007,17(2):90.[35]YangLR,XuXY.Effectofratserumcontainingdifferentconcentrationoftramethylpyrazineonproliferationofvascularendothelialcellsinvitro[J].Chi-ClinRehab,2005,9(27):223[36],,,.A[J].,2005,30(18):1448.[37],,,.[J].,2009,20(6):1400.[38].[J].,2008,43(12):723.[39],,,.[J].,2008,24(5):496.[40].[J].,2009,18(36):4512.[41]YangZ,ZhangQ,GeJ,etalProtectivee