含氮杂环化合物的研究进展

2011406PETROCHEMICALTECHNOLOGY檿檿檿檿檿檿檿檿檿檿檿檿檿檿檿檿檿檿檿檿殨殨殨殨2010－11－292011－03－22。1969—。[e-mail]。211189、。。。、、、。1000－8144201106－0579－06TQ25AStudyProgressinNitrogenousHeterocyclicCompoundsZhangJinXiaoGuominSchoolofChemistryandChemicalEngineerSoutheastUniversityNanjingJiangsu211189ChinaAbstractNitrogenousheterocycliccompoundscanbeusedasstructuralcomponentsofpharmaceuticalsandagrochemicalsduetotheirhighbiologicalactivitylowtoxicityandhighsystemicnatureandplayavitalroleinorganometalliccatalystsanddye-sensitizedsolarcells．Thenitrogenousheterocycliccompoundscanbemodifiedeasilystructurallywithvariousfunctionalgroups．Therearemanynitrogenouschemicalsespeciallypyridinebasesandtheirnumberisgrowingrapidly．Progressesinapplicationsofthenitrogenousheterocycliccompoundswithpyridineringtopharmaceuticalscatalystsandsolarcellswerereviewed．Thedevelopingprospectforpyridinebaseswasexplored．Pyridinebasedyesensitizerswithnovelstructureforsolarcellorganometalliccatalystswithhighactivityhighselectivityandlonglifehigh-performancephotoelectricmaterialsaredevelopingemphasesofthepyridinebases．Keywordsnitrogenousheterocycliccompoundorganometalliccatalystdye-sensitizedsolarcell。。、、Xu1－3、、。。。、。1·975·PETROCHEMICALTECHNOLOGY201140。、、、。1．11。1－Ⅰ4。1－Ⅱ5、、。1－Ⅲ6。1－Ⅳ7、、、、。1－Ⅴ8BoehringerIngelheim。1－Ⅵ9amirinone。1－Ⅶ10AstraZeneca20088Cleviprex。1－Ⅷ11、。1Fig．1Pyridinecompoundsusedintreatmentofthepatientswithcardiovascularandcerebrovasculardiseases．ⅠPrasugrelⅡDispyramideⅢAzelnidipineⅣTorasemideⅤDabigatranetexilateⅥMilrinoneⅦClevidipinebutyrateⅧNimodipine1．22。2－Ⅰ12、。2－Ⅱ13Uriach。2－Ⅲ14、。2－Ⅳ15－16H1。·085·6.2Fig．2Pyridinecompoundsfortreatmentofthepatientswithallergies．ⅠPheniramineⅡRupatadinefumarateⅢAcrivastineⅣBepotastinebesilate1．33。3－Ⅰ175－HT2D2D1α1、H1M1。3－Ⅱ18、。3ⅠⅡFig．3MolecularstructuralformulasofblonanserinⅠandpyritinolⅡ．1．44。19MitsubishiPharmaH+/K+－ATP．、。4Fig．4Molecularstructuralformulaoftenatoprazole．1．55。20BoehringerIngelhein2005622HIV。HIV－1HIVCD+4。5Fig．5Molecularstructuralformulaoftipranavir．1．66。6－Ⅰ21TosohCorporotionZen－yakuKogyo、、。6－Ⅱ22、。β、。6ⅠⅡFig．6MolecularstructuralformulasofliranaftateⅠandtelithromycinⅡ．1．77。7－Ⅰ23WyethⅡ。7－Ⅱ24Onyx·185·PETROCHEMICALTECHNOLOGY201140。25－28。7ⅠⅡFig．7MolecularstructuralformulasofneratinibⅠandnexavarⅡ．2、、。。。26－。26－/。8。Bianchini29Cs－C1－、8－ⅠMAOα－99%。ExxonMobil30MAO。318－Ⅱ。328－Ⅲα－98%。Enders338－Ⅳ1%98%。8Fig．8Pyridinecompoundsusedascatalysismaterials．3426－8－ⅤN2SiRpRqRrClRpRqRrC1～14、。35－trans－RuCl2py48－Ⅵ380℃、CO23MPaCO2100%。。336、、、。RuL2X2L44－－22－X。·285·6.9。374－2－－9－Ⅰ0．025%。。Wu389－Ⅱ700nm9．54%。Moorcraft39Pt4－CO2R－py2mntRHCH3mntPtXX’－CO2R－22’－bipyridylmntX=34bipyridyl。、。Pt4－CO2R－py2mnt9－ⅢTiO2。。Ning409－ⅣTiO29．59mA/cm、0．552V、0．54AM1．52．86%。9Fig．9Pyridinecompoundsappliedindye-sensitizedsolarcell．4。。、、、。、、。1XuYangXueSijia．SynthesisandBiologicalActivitiesofAlpha-AminoAcylaminesDerivativesContainingFuranandPyri-dineRingJ．ChemResChinUniv2009256846－850．2．J．20074611－10．3GeorgePLahmTPSelbyJHetal．InsecticidalAnthranilicDiamidesANewClassofPotentRyanodineReceptorActivatorsJ．BioorgMedChemLett200515224898－4906．4GlenmarkGenericsLimited．PreparationofPrasugrelandItsHydrochlorideSaltandCrystalFormsWO2010070677P．2010－06－24．5SumitomoChemicalCompanyLimited．ProcessforProducingLow-MeltingCrystalsofDisopyramideFreeBaseWO2005014548P．2005－02－17．6DipharmaFrancisS．r．l．PreparationMethodofAzelnidipineCrystalJP2010083888P．2010－04－15．7Societa'ItalianaMedicinaliScandicciS．I．M．S．S．r．l．ProcessforthePreparationofTorsemidebyAdditionof4-3-Methyl-phenylAmino-3-PyridinesulfonamidetoIsopropylIsocyanateIT1343259P．2007－12－19．8BoehringerIngelheimInternationalG．m．b．H．BoehringerIngelheimPharmaG．m．b．H．＆Co．K．-G．ImprovedProcessforthePreparationoftheSaltsof4-BenzimidazolylmethylaminoBenzamidesWO2007071743P．2007－06－28．9．J．2009194261－262．10．101759631P．2010－06－30．11SRIInternational．MethodsofTreatingConditionsAssociatedwithanEdg-7ReceptorUS2005261298P．2005－11－24．12HamidMHanitiSAAllenCetal．Ruthenium-CatalyzedN-AlkylationofAminesandSulfonamidesUsingBorrowing·385·PETROCHEMICALTECHNOLOGY201140HydrogenMethodologyJ．JAmChemSoc200913151766－1774．13CadilaHealthcareLimited．ProcessforPreparationofHighlyPureRupatadineandIntermediatesIN2006MU00864P．2008－07－04．14WareECKielJSThomasHetal．InProcessConversionMethodforPreparingTannateTabletCapsuleorOtherSolidDosageFormsUS2005202080P．2005－09－15．15．J．20063711726－727．16HanmiPharm．Co．Ltd．S．ProcessforPreparingBepotas-tineandIntermediatesUsedThereinWO2008153289P．2008－12－18．17OchiTSakamotoMMinamidaAetal．SynthesesandProper-tiesoftheMajorHydroxyMetabolitesinHumansofBlonanserinAD-5423aNovelAntipsychoticAgentJ．BioorgMedChemLett20051541055－1059．18．J．2009255493－495．19SripathiSBojjaRRKarnatiVR．AnImprovedSynthesisofAntiulcerativeDrugTenatoprazoleJ．OrgProcessResDev2009134804－806．20HoneywellInternationalInc．ProcessfortheSynthesisof3-Hydroxy-3-2-PhenylethylHexanoicAcidUsefulasanInter-mediateforAntiviralDrugsUS2004110957P．2004－06－10．21TosohCorp．O-5678-Tetrahydro-2-NaphthylN-6－Me-thoxy-2-Pyridyl-N-MethylthiocarbamateofMinimumInorganicSaltContentandTheirPreparationJP