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一、投稿时的Coverlatter1).Herewithinenclosedisourpaperforconsiderationtobepublishedon(Journalname).Thefurtherinformationaboutthepaperisinthefollowing:TheTitle:XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTheAuthors:XXXXXXXXXXXXXXXXXXXXXXandXXXXXXXXXXTheauthorsclaimthatnoneofthematerialinthepaperhasbeenpublishedorisunderconsiderationforpublicationelsewhere.Iamthecorrespondingauthorandmyaddressandotherinformationisasfollows:Address:DepartmentofXXXXXXXXX,CollegeofChemistryandEnviromentalScience,HenanNormalUniversityXinxiangCity,HenanProvince,453007,P.R.ChinaE-mail:Tel:+86-XXX-XXXXXXXFax:+86-XXX-XXXXXXXThankyouverymuchforconsideration!SincerelyYours,Dr.XXX2).DearDr.A:Iamsendingamanuscriptentitled“”by–whichIshouldliketosubmitforpossiblepublicationinthejournalof-.Yourssincerely3).DearDr.A:Enclosedisamanuscriptentitled“”bysb,whichwearesubmittingforpublicationinthejournalof-.Wehavechosenthisjournalbecauseitdealswith-.Webelievethatsthwouldbeofinteresttothejournal’sreaders.4).DearDr.A:Pleasefindenclosedforyourreviewanoriginalresearcharticle,“”bysb.Allauthorshavereadandapprovethisversionofthearticle,andduecarehasbeentakentoensuretheintegrityofthework.Nopartofthispaperhaspublishedorsubmittedelsewhere.Noconflictofinterestexitsinthesubmissionofthismanuscript,andwehaveattachedtothisletterthesignedlettergrantinguspermissiontouseFigure1fromanothersource.Weappreciateyourconsiderationofourmanuscript,andwelookforwardtoreceivingcommentsfromthereviewers.二、询问有无收到稿件DearEditors,Wedispatchedourmanuscripttoyourjournalon3August2006buthavenot,asyet,receiveacknowledgementoftheirsafearrival.Wefearthatmayhavebeenlostandshouldbegratefulifyouwouldletusknowwhetherornotyouhavereceivedthem.Ifnot,wewillsendourmanuscriptagain.Thankyouinadvanceforyourhelp.三、询问论文审查回音DearEditors，Itismorethan12weekssinceIsubmittedourmanuscript(No:)forpossiblepublicationinyourjournal.Ihavenotyetreceivedareplyandamwonderingwhetheryouhavereachedadecision.Ishouldappreciatedyourlettingmeknowwhatyouhavedecidedassoonaspossible.四、关于论文的总体审查意见1.Thisisacarefullydonestudyandthefindingsareofconsiderableinterest.Afewminorrevisionarelistbelow.2.Thisisawell-writtenpapercontaininginterestingresultswhichmeritpublication.Forthebenefitofthereader,however,anumberofpointsneedclarifyingandcertainstatementsrequirefurtherjustification.Therearegivenbelow.3.Althoughtheseobservationareinteresting,theyareratherlimitedanddonotadvanceourknowledgeofthesubjectsufficientlytowarrantpublicationinPNAS.Wesuggestthattheauthorstrysubmittingtheirfindingstospecialistjournalsuchas–4.Althoughthispaperisgood,itwouldbeeverbetterifsomeextradatawereadded.5.Thismanuscriptisnotsuitableforpublicationinthejournalof–becausethemainobservationitdescribewasreported3yearsagoinareputablejournalof-.6.PleaseasksomeonefamiliarwithEnglishlanguagetohelpyourewritethispaper.Asyouwillsee,Ihavemadesomecorrectionatthebeginningofthepaperwheresomesyntaxisnotsatisfactory.7.WefeelthatthispotentiallyinterestingstudyhasbeenmarredbyaninabilitytocommunicatethefindingcorrectlyinEnglishandshouldliketosuggestthattheauthorsseektheadviceofsomeonewithagoodknowledgeofEnglish,preferablenativespeaker.8.Thewordingandstyleofsomesection,particularlythoseconcerningHPLC,needcarefulediting.AttentionshouldbepaidtothewordingofthosepartsoftheDiscussionofandSummarywhichhavebeenunderlined.9.PreliminaryexperimentsonlyhavebeendoneandwithexceptionofthatsummarizedinTable2,nonehasbeenrepeated.Thisisclearlyunsatisfactory,particularlywhenthereissomuchvariationbetweenassays.10.Theconditionofincubationarepoorlydefined.Whatisthetemperature?Wereantibodyused?五、给编辑的回信1.Inreplytothereferee’smaincriticismofpaper,itispossibletosaythat–OneminorpointraisedbytherefereeconcernsoftheextracompositionofthereactionmixtureinFigure1.Thishasnowbeencorrected.Furtherminorchangeshadbeenmadeonpage3,paragraph1(line3-8)and2(line6-11).Thesedonotaffectourinterpretationoftheresult.2.Ihavereadthereferee’scommentsverycarefullyandconcludethatthepaperhasbeenrejectedonthesolegroundsthatitlaketoxicitydata.IadmitthatIdidnotincludeatoxicitytableinmyarticlealthoughperhapsIshouldhavedone.Thiswasforthesakeofbrevityratherthananerrororomission.3.Thankyouforyourletterof–andforthereferee’scommentsconcerningourmanuscriptentitled“”.Wehavestudiedtheircommentscarefullyandhavemadecorrectionwhichwehopemeetwiththeirapproval.4.Ienclosedarevisedmanuscriptwhichincludesareportofadditionalexperimentsdoneatthereferee’ssuggestion.Youwillseethatouroriginalfindingsareconfirmed.5.Wearesendingtherevisedmanuscriptaccordingtothecommentsofthereviewers.Revisedportionareunderlinedinred.6.Wefoundthereferee’scommentsmosthelpfulandhaverevisedthemanuscript7.Wearepleasedtonotethefavorablecommentsofreviewersintheiropeningsentence.8.Thankyouforyourletter.IamverypleasedtolearnthatourmanuscriptisacceptableforpublicationinCancerResearchwithminorrevision.9.Wehavethereforecompletedafurtherseriesofexperiments,theresultofwhicharesummarizedinTable5.Fromthisweconcludethatintrinsicfactorisnotaccount.10.Wedeletedtherelevantpassagesincetheyarenotessentialtothecontentsoft