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多靶点蛋白酪氨酸激酶抑制剂的研究进展作者：刘靖，王林，杨晓明，LIUJing，WANGLin，YANGXiao-ming作者单位：军事医学科学院放射与辐射医学研究所,北京,100850刊名：国际药学研究杂志英文刊名：JOURNALOFINTERNATIONALPHARMACEUTICALRESEARCH年，卷(期)：2009,36(3)被引用次数：1次参考文献(40条)1.WongTW;LeeFY;YuCPreclinicalantitumoractivityofBMS-599626,apan-HERkinaseinhibitorthatinhibitsHER1/HER2homodimerandheterodimersignaling[外文期刊]2006(20)2.WilhelmS;CarterC;LynchMDiscoveryanddevelopmentofsorafenib:amultikinaseinhibitorfortreatingcancer[外文期刊]2006(10)3.StrumbergD;SchultheisB;AdamietzIAPhaseⅠdoseescalationstudyoftelatinib(BAY57-9352)inpatientswithadvancedsolidtumours[外文期刊]2008(10)4.RixeO;BukowskiRM;MichaelsonMDAxitinibtreatmentinpatientswithcytokine-refractorymetastaticrenal-cellcancer:aphaseⅡstudy[外文期刊]2007(11)5.CoolsJ;StoverEH;BoultonCLPKC412overcomesresistancetoimatinibinamurinemodelofFIP1L1-PDGFRalpha-inducedmyeloproliferativedisease[外文期刊]2003(05)6.PolverinoA;CoxonA;StarnesCAMG706,anoral,multikinaseinhibitorthatselectivelytargetsvascularendothelialgrowthfactor,platelet-derivedgrowthfactor,andkitreceptors,potentlyinhibitsangiogenesisandinducesregressionintumorxenografts[外文期刊]2006(17)7.KeithCT;BorisyAA;StockwellBRMulticomponenttherapeuticsfornetworkedsystems[外文期刊]2005(01)8.LiuY;PoonRT;LiQBothantiangiogenesis-andangiogenesis-independenteffectsareresponsibleforhepatocellularcarcinomagrowtharrestbytyrosinekinaseinhibitorPTK787/ZK222584[外文期刊]2005(09)9.TraxlerP;AllegriniPR;BrandtRAEE788:adualfamilyepidermalgrowthfactorreceptor/ErbB2andvascularendothelialgrowthfactorreceptortyrosinekinaseinhibitorwithantitumorandantiangiogenicactivity[外文期刊]2004(14)10.HochhausA;KantarjianHM;BaccaraniMDasatinibinducesnotablehematologicandcytogeneticresponsesinchronic-phasechronicmyeloidleukemiaafterfailureofimatinibtherapy2007(06)11.CortesJ;RousselotP;KimDWDasatinibinducescompletehematologicandcytogeneticresponsesinpatientswithimatinib-resistantor-intolerantchronicmyeloidleukemiainblastcrisis2007(08)12.YokotaA;KimuraS;MasudaSINNO-406,anovelBCR-ABL/Lyndualtyrosinekinaseinhibitor,suppressesthegrowthofPh+leukemiacellsinthecentralnervoussystem,andcyclosporineaaugmentsitsinvivoactivity2007(01)13.DeiningerM;BuchdungerE;DrukerBJThedevelopmentofimatinibasatherapeuticagentforchronicmyeloid2005(07)14.SonpavdeG;HutsonTEPazopanib:anovelmultitargetedtyrosinekinaseinhibitor[外文期刊]2007(02)15.GarlandLL;PegramM;SongSPhaseⅠstudyofBMS-599626,anoralpan-HERtyrosinekinaseinhibitor,inpatientswithadvancedsolidtumors2005(23)16.BurrisHA;HurwitzHI;DeesECPhaseⅠsafety,pharmacokinetics,andclinicalactivitystudyoflapatinib(GW572016),areversibledualinhibitorofepidermalgrowthfactorreceptortyrosinekinases,inheavilypretreatedpatientswithmetastaticcarcinomas[外文期刊]2005(23)17.KonecnyGE;PegramMD;VenkatesanNActivityofthedualkinaseinhibitorlapatinib(GW572016)againstHER-2-overexpressingandtrastuzumab-treatedbreastcancercells[外文期刊]2006(03)18.Blume-JensenP;HunterTOncogenickinasesignalling[外文期刊]2001(6835)19.李岩;马洁肿瘤分子靶向治疗学200720.茆勇军;李海泓;李剑峰蛋白酪氨酸激酶信号转导途径与抗肿瘤药物[期刊论文]-药学学报2008(04)21.AroraA;ScholarEMRoleoftyrosinekinaseinhibitorsincancertherapy[外文期刊]2005(03)22.BeebeJS;JaniJP;KnauthEPharmacologicalcharacterizationofCP-547,632,anovelvascularendothelialgrowthfactorreceptor-2tyrosinekinaseinhibitorforcancertherapy[外文期刊]2003(21)23.NakamuraK;TaguchiE;MiuraTKRN951,ahighlypotentinhibitorofvascularendothelialgrowthfactorreceptortyrosinekinases,hasantitumoractivitiesandaffectsfunctionalvascularproperties[外文期刊]2006(18)24.LopesdeMenezesDE;PengJCHIR-258:apotentinhi-bitorofFLT3kinaseinexperimentaltumorxenograftmodelsofhumanacutemyelogenousleukemia[外文期刊]2005(14)25.GolasJM;ArndtK;EtienneC;JenniferMSKI-606,a4-anilino-3-quinolinecarbonitriledualinhibitorofSrcandAblkinases,isapotentantiproliferativeagentagainstchronicmyelogenousleukemiacellsincultureandcausesregressionofK562xenograftsinnudemice[外文期刊]2003(02)26.RabindranSK;DiscafaniCM;RosfjordECAntitumoractivityofHKI-272,anorallyactive,irreversibleinhibitoroftheHER-2tyrosinekinase[外文期刊]2004(11)27.DeJongeMJ;VerweijJMultipletargetedtyrosinekinaseinhibitionintheclinic:allforoneoroneforall?[外文期刊]2006(10)28.ChaudharyNI;RothGJ;HilbergFInhibitionofPDGF,VEGFandFGFsignallingattenuatesfibrosis[外文期刊]2007(05)29.LairdAD;VajkoczyP;ShawverLKSU6668isapotentantiangiogenicandantitumoragentthatinducesregressionofestablishedtumors[外文期刊]2000(15)30.MotzerRJ;RiniBI;BukowskiRMSunitinibinpatientswithmetastaticrenalcellcarcinoma[外文期刊]2006(21)31.ErlichmanC;HidalgoM;BoniJPPhaseⅠstudyofEKB-569,anirreversibleinhibitoroftheepidermalgrowthfactorreceptor,inpatientswithadvancedsolidtumors[外文期刊]2006(15)32.GartonAJ;CrewAP;FranklinMOSI-930:anovelselectiveinhibitorofKitandkinaseinsertdomainreceptortyrosinekinaseswithantitumoractivityinmousexenograftmodels[外文期刊]2006(02)33.PettiF;ThelemannA;KahlerJTemporalquantitationofmutantKittyrosinekinasesignalingattenuatedbyanovelthiophenekinaseinhibitorOSI-9302005(08)34.TrudelS;LiZH;WeiE;WiesmannMCHIR-258,anovel,multitargetedtyrosinekinaseinhibitorforthepotentialtreatmentoft(4;14)multiplemyeloma2005(07)35.CamposS;HamidO;SeidenMVMulticenter,randomizedphaseⅡtri