血红素加氧酶-1的研究及应用进展-陆献成

©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[](1967-),,,,[],E2mail:[e-mail]21,(,210009)[]21;;[]Q786[]A[]1671-7562(2007)01-0072-04EC,(HO)HO,[1]HO,3,HO21HO22HO23,,HO21HO2240%,HO22HO2390%HO21HO22HO3HO23,HO22,HO21,HO22[2]HO211HO21HO2132(HSP32),32000,22q12,,,,HO21,(CO)Fe2+,,Fe2+(NADPH)O2,,;Fe2+,[3];CO,HO21HO21,,O2,HO21CO,Fe2+[4],HO21Fe2+,Fe2+[5],Fe2+;HO21,,,[6];CO,CONO,(GTP)(cGMP),;COK+,(ET21)[7],COP38MAPK,,[8],CO2HO21HO21,27(ModernMedicalJournal),20072,351©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(AP21),NF2BAP21HO21HO21,HO21,HO21,HO21[9]21(AP21),NF2E22(Nrf2)Nrf2HO21,,HO2110bp,(StRE),,StREAP21,HO21,StREHO21,AP21HO2121(HIF21),HO21HO21[10]HIF21,,MAPK23HIF21[11]3HO213.1HO21(CAD)1994Schwertner[12]CAD,,HopkinsCADHuntCADCAD,CADCAD,CAD,CADCAD[13-14],,HO21CADHO21(Heme),Heme;COcGMP,,;HO21,HO21CAD3.2,,HO21,Clark[6]24h(HO21),,HO21,,(HSP),HO21,[15],HO21,VulapalliHO21,HO21,HO21HO22HSP90,HO21HO21O2,HO21,HO21CO,Yet[16]CO,37(ModernMedicalJournal),20072,351©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(VCAM21)21(ICAM21),,CO,Soares[17]HO21(TNF2)Vulapalli[18]HO21,,HO21CO,HO21Bcl2caspase23,HO213.3,,,,,,,HO21Wister2(Ang2),Ang2[19]Ang2Ang2,HO21HuAng2Ang2,HO21,,,,HO21,4HO21HO21HO213CO,,HO21,,,HO21,HO21,HO21,HO21,;3HO21HO21,HO21[][1]YachieA,NiidaY,WadaT,etal.Oxidativestresscausesen2hancedendothelialcellinjuryinhumanhemeoxygenase21defi2ciency[J].JClinInvest,1999,103(1):129-135.[2]WagenerFA,daSilvaJL,FarleyT,etal.Differentialeffectsofhemeoxygenaseisoformsonhememediationofendothelialin2tracellularadhesionmolecule1expression[J].JPharmacolExpTher,1999,291(1):416-423.[3]AlayashAI,PatelRP,CashonRE.Redoxreactionsofhemo2globinandmyoglobin:biologicalandtoxicologicalimplications[J].AntioxidRedoxSignal,2001,3(2):313-327.[4]TortiFM,TortiSV.Regulationofferritingenesandprotein[J].Blood,2002,99(10):3505-3516.[5]BarananoDE,WoloskerH,BaeBI,etal.AmammalianironATPaseinducedbyiron[J].JBiolChem,2000,275(20):15166-15173.[6]ClarkJE,ForestiR,SarathchandraP,etal.Hemeoxygenase212derivedbilirubinamelioratespostischemicmyocardialdysfunction[J].AmJPhysiolHeartCircPhysiol,2000,278(2):H643-H651.[7]ChenYH,YetSF,PerrellaMA.Roleofhemeoxygenase21intheregulationofbloodpressureandcardiacfunction[J].ExpBiolMed,2003,228(5):447-451.[8]SongR,NingW,LiuF,etal.RegulationofIL21beta2inducedGM2CSFproductioninhumanairwaysmoothmusclecellsbycarbonmonoxide[J].AmJPhysiolLungCellMolPhysiol,2003,284(1):L50-L56.[9]OkinagaS,TakahashiK,TakedaM,etal.Regulationofhuman47(ModernMedicalJournal),20072,351©1994-2010ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[J].Blood,1996,87(12):5074-5084.[10]LeePJ,JiangBH,ChinBY,etal.Hypoxia2induciblefactor21mediatestranscriptionalactivationofthehemeoxygenase21geneinresponsetohypoxia[J].JBiolChem,1997,272(9):5375-5381.[11]BiltonRL,BookerGW.Thesubtlesidetohypoxiainduciblefactor(HIF)regulation[J].EurJBiochem,2003,270(5):791-798.[12]SchwertnerHA.Associationofsmokingandlowserumbiliru2binantioxidantconcentrations[J].Atherosclerosis,1998,136(2):383-387.[13]MylonasC,KouretasD.Lipidperoxidationandtissuedamage[J].InVivo,1999,13(3):295-309.[14]RossR.Atherosclerosisaninflammatorydisease[J].NEnglJMed,1999,340(2):115-126.[15]WagenerFA,VolkHD,WillisD,etal.Differentfacesoftheheme2hemeoxygenasesystemininflammation[J].PharmacolRev,2003,55(3):551-571.[16]YetSF,TianR,LayneMD,etal.Cardiac2specificexpressionofhemeoxygenase21protectsagainstischemiaandreperfusioninjuryintransgenicmice[J].JCircResAm,2001,89(2):168-173.[17]SoaresMP,LinY,AnratherJ,etal.Expressionofhemeoxy2genase21candeterminecardiacxenograftsurvival[J].NatMed,1998,4(9):1073-1077.[18]VulapalliSR,ChenZ,ChuaBH,etal.Cardioselectiveoverex2pressionofHO21preventsI/R2inducedcardiacdysfunctionandapoptosis[J].AmJPhysiolHeartCircPhysiol,2002,283(2):H688-H694[19]NakagamiH,TakemotoM,LiaoK.NADPHoxidase2derivedsuperoxideanionmediatesangiotensin2inducedcardiachy2pertrophy[J].JMolCellCardiol,2003,35(7):851-859.[]2006-06-23[](1982-),,,[],E2mail:[e-mail]212,(,210009)[];;;[]R730[]A[]1671-7562(2007)01-0075-041971,Folkman[1],(angio2poietin,Ang)[2]Ang21,2,3,4,Ang212,Ang21Ang221Ang21Ang221.1Ang21Ang22Ang211996Davis[3]Ang218(8q22.3q23),1497bp,498Ang21,75000Ang22Maisonpierre[4]1997cDNAAng228(8q23.1),1491bp,496Ang21,Ang22,N2(coiled2coildomain,CC)C(fibrinogen2likedomain,FL):(1)Ang21Ang22N21020,(2)18020057(ModernMedicalJournal),20072,351