txhxxj@126.comApplicationofHPLC-MSinPharmaceuticalAnalysisTANGXue-hong,XIAOXian-ji(XuzhouIndustrialVocationalandTechnicalInstitute,JiangsuXuzhou221140,China)Abstract:ResearchprogressofHPLC-MSaccesstechniquewasintroduced,andapplicationofHPLC-MSwassummarized,suchasstudyoftraditionalChinesemedicinefingerprintspectrum,drugmetabolismanalysis,analysisofillegaladditivechemicaldrugsinmedicationandanalysisofresidualdrugs.WiththedevelopmentoftheHPLC-MStechnology,HPLC-MSwillplayanincreasinglyimportantroleinpharmaceuticalanalysis.Keywords:HPLC-MS;Accesstechnique;Pharmaceuticalanalysis/~~~rn~r~结语