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SCI论文投稿coverletter投稿信模版DeareditorialboardofEuropeanJournalofCardiology,Pleasefindenclosedthemanuscript:“Theangiotensin-convertingenzymeisnotariskfactorformyocardialinfarctioninFrenchindividuals”,bySarahH.,etal.,tobesubmittedasaShortCommunicationtotheEuropeanJournalofNeurologyforconsiderationofpublication.Allco-authorshaveseenandagreewiththecontentsofthemanuscriptandthereisnofinancialinteresttoreport.Wecertifythatthesubmissionisoriginalworkandisnotunderreviewatanyotherpublication.Inthismanuscript,wereporttheresultsofthefirststudyonthegeneticandfunctionalrolesoftheACEontheriskofsufferingamyocardialinfarctionintheFrenchpopulation.Indeed,wegenotypedthers4341polymorphismin531IScasesand549healthycontrols,andthenperformedfunctionalstudiesbymeasuringserumACEproteinlevelandactivityinhealthycontrols,strokepatientsatbaselineandstrokepatients24hafterstrokesymptomsonset.TheresultsfromourstudydidnotrevealanyassociationoftheACEvariantwithmyocardialinfarction,althoughitaffectedACEproteinlevel,andischemicstrokepatientsshowedlowerACElevelthancontrolsintheacutephasebutnotinthechronicphase.WebelievethatourfindingscouldbeofinteresttothereadersofEuropeanJournalofCardiologybecausetheybringnewandstrongevidencethattheACEgeneandproteinarenotariskfactorformyocardialinfarction.Wehopethattheeditorialboardwillagreeontheinterestofthisstudy.Sincerelyyours,SarahH.onbehalfoftheauthors.Correspondingauthor:SarahHamiltonatCardiovascularResearchLaboratory,MarieCurieResearchInstitute,75000,Paris,France,xxx@mariecurie.fr,phonenumber:+33582246xxx,faxnumber:+33582246xxx.Case1DearEditor,WewouldliketosubmittheenclosedmanuscriptentitledGDNFAcutelyModulatesNeuronalExcitabilityandA-typePotassiumChannelsinMidbrainDopaminergicNeurons,whichwewishtobeconsideredforpublicationinNatureNeuroscience.GDNFhaslongbeenthoughttobeapotentneurotrophicfactorforthesurvivalofmidbraindopaminergicneurons,whicharedegeneratedinParkinson’sdisease.Inthispaper,wereportanunexpected,acuteeffectofGDNFonA-typepotassiumchannels,leadingtoapotentiationofneuronalexcitability,inthedopaminergicneuronsincultureaswellasinadultbrainslices.Further,weshowthatGDNFregulatestheK+channelsthroughamechanismthatinvolvesactivationofMAPkinase.Thus,thisstudyhasrevealed,forthefirsttime,anacutemodulationofionchannelsbyGDNF.OurfindingschallengetheclassicviewofGDNFasalong-termsurvivalfactorformidbraindopaminergicneurons,andsuggestthatthenormalfunctionofGDNFistoregulateneuronalexcitability,andconsequentlydopaminerelease.TheseresultsmayalsohaveimplicationsinthetreatmentofParkinson’sdisease.Duetoadirectcompetitionandconflictofinterest,werequestthatDrs.XXXofHarvardUniv.,andYYofYaleUniv.notbeconsideredasreviewers.Withthanksforyourconsideration,IamSincerelyyours,case2DearEditor,WewouldliketosubmittheenclosedmanuscriptentitledCa2+-bindingproteinfrequeninmediatesGDNF-inducedpotentiationofCa2+channelsandtransmitterrelease,whichwewishtobeconsideredforpublicationinNeuron.WebelievethattwoaspectsofthismanuscriptwillmakeitinterestingtogeneralreadersofNeuron.First,wereportthatGDNFhasalong-termregulatoryeffectonneurotransmitterreleaseattheneuromuscularsynapses.Thisprovidesthefirstphysiologicalevidenceforaroleofthisnewfamilyofneurotrophicfactorsinfunctionalsynaptictransmission.Second,weshowthattheGDNFeffectismediatedbyenhancingtheexpressionoftheCa2+-bindingproteinfrequenin.Further,GDNFandfrequeninfacilitatesynaptictransmissionbyenhancingCa2+channelactivity,leadingtoanenhancementofCa2+influx.Thus,thisstudyhasidentified,forthefirsttime,amoleculartargetthatmediatesthelong-term,synapticactionofaneurotrophicfactor.Ourfindingsmayalsohavegeneralimplicationsinthecellbiologyofneurotransmitterrelease.Sincerelyyours,Case3SampleCoverLetter[theexampleusedistheIJEB]DearEditorofthe[pleasetypeinjournaltitleoracronym]:Enclosedisapaper,entitledMobileAgentsforNetworkManagement.Pleaseacceptitasacandidateforpublicationinthe[journaltitle].Belowareourresponsestoyoursubmissionrequirements.1.Titleandthecentralthemeofthearticle.Papertitle:MobileAgentsforNetworkManagement.Thisstudyreviewstheconceptsofmobileagentsanddistributednetworkmanagementsystem.Itproposesamobileagent-basedimplementationframeworkandcreatesaprototypesystemtodemonstratethesuperiorperformanceofamobileagent-basednetworkovertheconventionalclient-serverarchitectureinalargenetworkenvironment.2.Whichsubject/themeoftheJournalthematerialfitsNewenablingtechnologies(ifnomatchingsubject/theme,enter'Subjecthighlyrelatedto[subjectofjournal]butnotlistedby[pleasetypeinjournaltitleoracronym])3.Whythematerialisimportantinitsfieldandwhythematerialshouldbepublishedin[pleasetypeinjournaltitleoracronym]?Thenecessityofhavinganeffectivecomputernetworkisrapidlygrowingalongsidetheimplementationofinformationtechnology.Findinganappropriatenetworkmanagementsystemhasbecomeincreasinglyimportanttoday'sdistributedenvironment.However,theconventionalcentralizedarchitecture,whichroutinelyrequeststhestatusinformationoflocalunitsbythecentralserver,isnotsufficienttomanagethegrowingrequests.Recently,anewframeworkthatuse