氨基酸周期表和常见氨基保护集团

HisHistidineH155.16137.14C6H9N3O2ArgArginineR174.20156.19C6H14N4O2LysLysineK146.19128.17C6H14N2O2IleIsoleucineI131.18113.16C6H13NO2PhePhenylalanineF165.19147.18C9H11NO2LeuLeucineL131.18113.16C6H13NO2TrpTryptophanW204.23186.21C11H12N2O2AlaAlanineA89.0971.08C3H7NO2MetMethionineM149.21131.20C5H11NO2SProProlineP115.1397.12C5H9NO2CysCysteineC121.16103.14C3H7NO2SAsnAsparagineN132.12114.10C4H8N2O3ValValineV117.1599.13C5H11NO2GlyGlycineG75.0757.05C2H5NO2SerSerineS105.0987.08C3H7NO3GlnGlutamineQ146.15128.13C5H10N2O3TyrTyrosineY181.19163.17C9H11NO3AspAsparticAcidD133.10115.09C4H7NO4GluGlutamicAcidE147.13129.11C5H9NO4ThrThreonineT119.12101.10C4H9NO3PeriodicChartofAminoAcids–H20MolecularFormula3-LetterAminoAcidCodeChemicalStructureChemicalNameBasicNon-polar(hydrophobic)Polar,unchargedAcidicCommonFmoc-StrategySPPS*ProtectingGroupsFmoc9-Fluorenylmethyloxy-carbonylMr=223.25Mtt4-MethyltritylMr=257.36Pmc2,2,5,7,8-Pentamethyl-chroman-6-sulfonylMr=267.37EP0293073B1USPatent4,946,971ownedbyBachemtBut-ButylMr=57.12FluorophoreExcitationWavelengthEmissionWavelengthAbz(2-AminobenzoylorAnthraniloyl)320nm420nmN-Me-Abz(N-Methyl-anthraniloyl)340-360nm440-450nmAFC(7-Amido-4-trifluoromethylcoumarin)395-400nm495-505nmAMC(7-Amido-4-methylcoumarin)360-380nm440-460nmDansyl(5-(Dimethylamino)naphthalene-1-sulfonyl)342nm562nmEDANS(5-[(2-Aminoethyl)amino]naphthalene-1-sulfonicacid)340nm490nmFITC(Fluoresceinisothiocyanate)490nm520nmMca((7-Methoxycoumarin-4-yl)acetyl)325nm392nm4MβNA(4-Methoxy-β-naphthylamide)335-350nm410-440nmβNA(β-Naphthylamide)320-340nm410-420nmTrp(Tryptophan)280nm360nmChromophoreExtinctionWavelengthMolarExtinctionCoefficientpNA(p-Nitroanilide)405nm410nmε405nm=9450M-1cm-1ε410nm=8800M-1cm-1CommonBoc-StrategySPPS*ProtectingGroupsBoct-ButyloxycarbonylMr=101.13TosTosylMr=155.20Mbzl4-MethylbenzylMr=105.16BomBenzyloxymethylMr=121.162-Chloro-Z2-Chlorobenzyloxy-carbonylMr=169.59ForFormylMr=29.02Bachem.Leadingbeyondpeptides©CopyrightbyBachemAG,Switzerland.Reproductionforbiddenwithoutpermission.peptidesbuildingblocksimmunologyproductscustomsynthesiscGMPValueslistedareasreportedintheliterature*SPPS=SolidPhasePeptideSynthesisAbsorptionandEmissionCharacteristicsofChromophoresandFluorophores