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SpeakerAssociationofrelativehandgripstrengthwithmetabolicprofileandmetabolicdiseaseinthegeneralpopulationinChinaEpidemiologyandStatisticsDongLiYanSupervisor2017.12.26DateSchoolofPublicHealthrelativehandgripstrength;metabolism;metabolicdiseaseContentsContentsPart1Part2Part3Part4Part5BackgroundMethodsResultsDiscussionConclusionContentsBackgroundPart1RelativehandgripstrengthMetabolicdisease41.BackgrounddiabetesmellitusfuturedisabilityHandgripstrengthfrailtymetabolicsyndromediabetesmellitusfuturedisabilityDong,R.,etal.,ClinicalRelevanceofDifferentHandgripStrengthIndexesandMobilityLimitationintheElderlyAdults.51.BackgroundNoassociationbetweenhandgripstrengthandincidentalonlymoderatelyornotassociatedwithcardiovascularriskmarkersHandgripstrengthwasassociatedwithprediabetesamongnormal-weightAmericans,SouthAsians,andelderlyChinese.However,otherstudiesshowedcontradictoryresultsConflictZhang,W.,etal.,PLoSOne,2014.9(12):p.e115883.Mainous,A.G.,3rd,etal.,JAmBoardFamMed,201629(2):p.280-2.Ntuk,U.E.,etal.,DiabetMed,2017.Gubelmann,C.,P.VollenweiderEurJPrevCardiol,2016:p.2047487316680695.6Sincethehandgripstrengthwascloselyrelatedtobodymass,usinghandgripstrengthasanindicatorofmusclestrength,whenwithoutcorrectionforbodymass,maybeacontributingcauseoftheaboveconflictingresults.Relativehandgripstrengthtobeanindicatorofcardiometabolicriskamongmiddle-ageandelderlypersons.“”1.BackgroundGubelmann,C.,P.Vollenweider,andP.Marques-Vidal,Noassociationbetweengripstrengthandcardiovascularrisk:TheCoLauspopulation-basedstudy.IntJCardiol,2017.236:p.478-482.7However,itisstillnotclearwhichmeasurement,handgripstrengthorrelativehandgripstrengthorboth,areassociatedwiththemetabolicprofileandmetabolicdisorders.InspirationThisstudy,aimedatassessingtheassociationofrelativehandgripstrengthwithmetabolicprofileandmetabolicdiseaseinthegeneralpopulationinChina.Objective1.BackgroundMethodsPart2StudyPopulationMetabolicDiseaseDataCollectionStatisticalAnalysis92.Methodslessthan18yearsold；sufferedrecentinjurie，handorwristsurgery；withoutcompleteinformationtodefinethemetabolicdiseases.StudyPopulation4321Populationatotalof5520(2289males,3231females)aged18-79yearssubjectswereincludedinthisstudy.10DatacollectionAnthropometricmeasurementsmetabolicprofileFPG,TC,TG,HDL-C,LDL-CQuestionnaireDemographicdata;smoking,alcoholdrinkingeducationalstatus2.Methods1432bodyweight,bodyheight,waistcircumferenceandhipcircumferencerelativehandgripstrengthRHGS=HGS/BMI11DefinitionsofMetabolicDiseaseT2DM:FPG≥7.0mmol/lor2hglucoselevels≥11.1mmol/linanoralglucoseIFG:FPG≥5.6mmol/l,6.9mmol/lDyslipidemia：2.Methods2143TC:5.18-6.19mmol/LTG:1.70-2.15mmol/LLDL-C:3.38-4.13mmol/LHDL-C:1.04mmol/LTC:≥6.20mmol/L,TG:≥2.16mmol/L,LDL-C:≥4.14mmol/LHyperlipidemia：12StatisticalanalysisSoftware:SPSS23.0;R,version3.0.4Independentt-testChisquaretestmultiplelinearregressionMultivariatelogisticregressionTwo-sidedandP0.052.Methods3214ResultsPart3LogisticregressionCharacteristicsofparticipantsForestplot143.1CharacteristicsofparticipantsPvalueswerefromChi-squareorStudent’st-testscomparingmalesandfemales.153.2MultiplelinearregressionMale(n=2289)Female(n=3231)P1P2ValueB(95%CI)P1P2B(95%CI)GLU0.0010.001-0.30(-0.46--0.15)0.0010.12-0.16(-0.32-0.04)HDL-C0.0010.0010.19(0.15-0.23)0.0010.0010.22(0.17-0.28)LDL-C0.0010.003-0.14(-0.23--0.05)0.0010.001-0.19(-0.31--0.08)TC0.0010.001-0.20(-0.31--0.10)0.0010.005-0.19(-0.32--0.06)TG*0.0010.001-0.58(-0.74--0.43)0.0010.001-0.55(-0.74--0.36)Table2.AssociationbetweenrelativehandgripstrengthandmetabolicprofileGLU:serumglucose,HDL-C:highdensitylipoproteincholesterol,LDL-C:lowdensitylipoproteincholesterol,TC:totalcholesterol,TG*:meansoflog-transformedfortriglyceride.P1valueswerefromPearsoncorrelation.P2valueswerefrommultivariablelinearregression,inwhichage,sex,smoking,alcoholdrinkingandeducationalstatuswasadjusted.163.3LogisticregressionanalysisIFGDyslipidemiaRHGSNEvents,n(%)OR(95%CI)PEvents,n(%)OR(95%CI)PMaleQ1(≤1.31)576111(19.3)reference337(58.5)referenceQ2(1.32-1.52)53495(17.8)0.96(0.69-1.34)0.82322(60.3)0.95(0.71-1.27)0.74Q3(1.53-1.76)53766(12.3)0.66(0.45-0.95)0.027269(50.1)0.65(0.48-0.87)0.004Q4(≥1.77)57143(7.5)0.46(0.30-0.71)0.001222(38.9)0.47(0.35-0.64)0.001FemaleQ1(≤0.74)780144(18.6)reference551(70.6)referenceQ2(0.75-0.92)740101(13.7)0.99(0.74-1.33)0.96478(64.6)0.87(0.68-1.12)0.28Q3(0.93-1.09)77168(8.8)0.77(0.55-1.08)0.13427(55.4)0.68(0.53-0.86)0.002Q4(≥1.10)79446(5.8)0.72(0.48-1.06)0.10347(43.7)0.47(0.36-0.61)0.001Table3.AssociationofrelativehandgripstrengthwithpreclinicalstagemetabolicdiseaseCI:confidenceinterval;RHGS:relativehandgripstrength.Pvalueswerefromlogisticregression,inwhichage,sex,smoking,alcoholdrinkingandeducationalstatuswasadjusted.173.3LogisticregressionanalysisTable4.AssociationofrelativehandgripstrengthwithmetabolicdiseaseCI:confidenceinterval;RHGS:relativehandgripstrength.Pvalueswerefromlogisticregression,inwhichage,sex,smoking,alcoholdrinkingandeducationalstatuswasadjusted.DiabetesHyperlipidemiaRHGSNEvents,n(%)OR(95%CI)PEvents,n(%)OR(9