三七皂苷类成分及对心血管作用的研究进展-李娟

201594017Vol.40No．17September2015122212*1.2100382.201203Panaxnotoginseng、、、。、、。。。4PPDPPTC17。。2015-06-20U103260412401900403*[e-mail][e-mail]lactiononcardiovascularsystemsofsaponinsfromPanaxnotoginsengLIJuan12WANGＲu-feng2YANGLi2WANGZheng-tao12*1.DepartmentofPharmacognosyChinaPharmaceuticalUniversityNanjing210038China2.TheMinistryofEducationKeyLaboratoryforStandardizationofChineseMedicinesandShanghaiKeyLaboratoryofCompoundChineseMedicinesInstituteofChineseMateriaMedicaShanghaiUniversityofTraditionalChineseMedicineShanghai201203ChinaAbstractNotoginsengＲadixetＲhizomaSanqitheundergroundpartofPanaxnotoginsengBurk.F.H.ChenAraliaceaeiscommonlyusedinChinesemedicinefortreatmentofhaemorrhagehaemostasisswellingetc.Theaerialpartincludingleavesflow-ersandfruitsarealsoappliedforsimilarfunctions.TriterpenoidsaponinsareconsideredtoberesponsibleforthebiologicalactivitiesofSanqi.Uptodatemorethan100saponinshavebeenisolatedfromtherootsrhizomesleavesflowersandfruitsofP.notoginseng.ThereportedsaponinscanbeclassifiedintoprotopanaxadiolPPDprotopanaxatriolPPTC17side-chainvariedandothertypesaccordingtotheskeletonsoftheaglycons.ThepresentreviewsummarizesthesaponinsisolatedfromP.notoginsengandtheirdistribu-tionindifferentmedicinalorgansaswellasthepharmacologicalactionsoncardiovascularsystem.KeywordsPanaxnotoginsengsaponinsdistributioncardiovascularsystemdoi10．4268/cjcmm20151726PanaxnotoginsengBurk.F.H.Chen、1。《》“”。、。、。、、。、、、、2。·0843·。4PPDPPTC17。。11.1P.notoginsengP.ginsengC.A.Meyer、P.quinquefolinusL.。1854、、、、、、、、。。2。C6protopanax-adiolPPD、protopanaxatriolPPToctotillol33-6。。PPDＲb1ＲdＲb3ＲcＲg3FcFaⅨⅩⅦ1PPTＲ1Ｒ2Ｒg1ＲeＲg22。Ｒb1Ｒb3ＲcＲg1ＲeⅨⅩⅦＲ1Fc。C173。。7Ft1Ft2Ft3。8SFt1-SFt4。Liao9-10Teng11-12ST1～ST5T1～T5。PPD、PPT4I12G56。1Fig．1ProtopanaxadiolPPDtypenotoginsenosidesx1.2、、、、1～3。、PPDPPTＲg1Ｒb1Ｒ13。Ｒb3ＲcＲb1FcFaⅨPPDPPT。Ｒb1ＲcＲb3。Wang13ABCDOLXIXLXXI。1420Ｒ20Ｒ-Ｒh120Ｒ-Ｒh220Ｒ-Ｒg120Ｒ-Ｒg220Ｒ-Ｒg3。·1843·201594017Vol.40No．17September20152Fig.2ProtopanaxatriolPPTtypenotoginsenosides3C17Fig．3NotoginsensideswithC17side-chainvaried·2843·4Fig．4Othertypesnotoginsenosides1Table1ProtopanaxadiolPPDtypenotoginsenosidesNo.No.1ginsenosideCKNGL151620notoginsenosideLNGＲ342ginsenosideF2NGＲh18NGL19NGF2021notoginsenosideFcNGL33NGFs233ginsenosideM3/McNGＲ21NGL15162122notoginsenosideFeNGL33NGF25NGFs264ginsenosideＲb1NGＲ17NGＲh46NGL19NGF20NGFr14NGFs2323notoginsenosideFaNGＲ17NGＲh27NGL19NGFs235ginsenosideＲb2NGＲ22NGL24NGF2024notoginsenosideONGF306ginsenosideＲb3NGL19NGF25NGFr14NGFs2625notoginsenosidePNGF307ginsenosideＲcNGL19NGF2520NGFs2626notoginsenosideQNGF308ginsenosideＲdNGＲ17NGＲh46NGL19NGF20NGFr1427notoginsenosideＲ4NGＲ17319ginsenosideＲg3NGＲh27NGL1928notoginsenosideSNGF30NGＲh4610ginsenosideＲ-Ｒg3NGＲ17NGＲh27NGL21NGFr1429notoginsenosideTNGF30NGＲh4611ginsenosideＲh2NGL1930notoginsenosideFt1NGLinacid712ginsenosideＲ-Ｒh2NGＲ21NGL21NGFr1431notoginsenosideFP2NGFs28NGF1313gypenosideIXNGL19NGF25NGFs262832notoginsenosideFzNGL357014gypenosideXIII/MxNGL19NGF29NGFs2833notoginsenosideST4NGＲsteamed1015gypenosideXVNGF30NGFs2334quinquenosideＲ1NGＲ3116gypenosideXVIINGＲ31NGL19NGFs2335saponin1NGＲ2217vinaginsenosideＲ7NGL3236saponin2NGＲ2218mal-ginsenosideＲb1NGＲ1537ginsenosideＲa3NGＲ1719notoginsenosideDNGＲ1731NGＲ．rootNGＲh．rhizomeNGL．leafNGF．flowerNGFr．fruitNGFs．FruitstemGlc．β-D-glucopyranoseXyl．β-D-xylopyranoseＲha．α-L-ＲhamnopyranoseArafα-L-arabifuranoseArap．α-L-arabipyranose23。2Table2ProtopanaxatriolPPTtypenotoginsenosidesNo.No.38ginsenosideF1NGＲ17NGＲh18NGL2151notoginsenosideＲ3NGＲ2237NGＲh7139ginsenosideＲeNGＲ17NGＲh71NGL19NGF29NGFr14NGFs2652notoginsenosideＲ6NGＲ3740ginsenosideＲg1NGＲ17NGＲh27NGL1953notoginsenosideT3NGＲinacid1241ginsenosideＲg1NGFr1454notoginsenosideUNGＲ3842ginsenosideＲg2NGＲ17NGＲh27NGFr1455notoginsenosideFP1NGFs2843ginsenosideＲh1NGＲ17NGＲh46NGL152156notoginsenosideＲW1NGＲh3944ginsenosideＲh1NGＲ17NGFr1457pseudoginsenosideＲT3NGＲ4045koyoginsenosideＲ1NGＲh2758vinaginsenosideＲ4NGＲ174620-O-glucoginsenosideＲfNGＲ31NGＲh7359saponin4NGＲ1747notoginsenosideMNGＲ3460saponin5NGＲ1748notoginsenosideNNGＲ3461saponin6NGＲ1749notoginsenosideＲ1NGＲ17NGＲh46NGFs26626'-O-acetylginsenosideＲh1NGＲ1750notoginsenosideＲ2NGＲ17NGＲh27·3843·201594017Vol.40No．17September20153C17Table3NotoginsenosideswithchangedC-17sidechainandothertypesNo.No.63ginsenosideIINGＲh1887notoginsenosideST1NGＲsteamed964notoginsenosideCNGＲ3188notoginsenosideT1NGＲinacid11-1265floranotoginsenosideBNGF1389notoginsenosideT2NGＲinacid11-1266floranotoginsenosideCNGF1390notoginsenosideＲ10NGＲ4567floranotoginsenosideDNGF1391ginsenosideＲh4NGＲ17NGＲh4668notoginsenosideBNGＲ3192notoginsenosideT5NGＲ12NGＲh1869notoginsenosideENGＲ42NGＲh1893notoginsenosideＲ9NGＲ4770notoginsenosideKNGＲ3494notoginsenosideＲ8NGＲ4771floraginsenosideONGF1395notoginsenosideＲw2NGＲh3972gypenosideLXIXNGF1396notoginsenosideJNGＲ4273notoginsenosideST5NGＲsteamed997notoginsenosideANGＲ3174floranotoginsenosideANGF1398notoginsenosideHNGＲ4275notoginsenosideSFt2NGLsteamed899saponin3NGＲ2276notoginsenosideFt2NGLinacid7100vinaginsenosideＲ15NGＲ4077notoginsenosideFt3NGLinacid7