三七总皂苷的药理作用研究进展

:2006209206;:2006212217:(19812),(),,,.1,2,2(1.,130117;2.,130021):,:;:R285.5:B:100820805(2007)0521251202(totalsaponinsofPanaxnotognseng,PNS),2040,PNS,,PNS11.1,PNS,,,[1]1.2PNS,PNS,[2]1.3PNS(IBA),(Ach)[3]PNS40%ATP[4]22.1PNS-PNSGsmRNA,PNS,,cAMP[5]-NF2KB,NF-KBICAM21-;PNS-KB,[6]2.2[7],PNSPNS,,,,;,[8]2.3,,,[9](SMCs)PNS,PNSSMCs,[10]PNS2.4PNS,PNSCa2+[7],33.1PNS,,PNS(BMP)(CVR),BMPCVR,,,3.2PNS,PNS,,Ca2+,CAM,,(MDA),[11]PNSIL28,,,[12],PNSNOIL21TNF,,[13]44.1PNS,(ADP),,A2(TXA2)[14]4.2PNS,GATA21GATA22,,[15]55.1PNSTNF2,NF2KB.NF2KB,TNF2mRNA[16];,,MDA,(Neu)O2-,NeucAMP,O22[17]5.2PNS,,,,,-,-,NK[18]66.1,1521LISHIZHENMEDICINEANDMATERIAMEDICARESEARCH2007VOL.18NO.52007185PNSKFBI,KFB1[9],,2,[20]6.2PNSTGF21,,,[21]6.3PNS,,TNF2IL-6[22];[23]7,,PNS(SOD),(GSH),(CAT),[24]8PNSPNSNB4NBT,100200mg/LNB4[25]PNSGES21(MNNG)GES21HPGES21PNS[26]9PNS,[27]PNS,PNS,[28]PNS,,[29]PNS,(OPG)[30]10,PNS,,,,,,,,,,,,,PNS:[1],.[J].,1998,14(4):309.[2]CiceroAF,VitaleG.,SavionG.,eta1.Panaxnotoginseng(Burk)effectsfibrinogenandlipidplasmaleverinratsfedonahigh-fatdiet[J].Phytother.Res.,2003,17:174.[3],,.[J].,2004,15(10):598.[4]JinSH,ParkIK,NamKY,eta1.Koreanredginsengsaponinswithrati2osofprotopanaxadiolandprotopanaxatriolsaponinimprovescopolamine-inducedlearningdisabilityandspatialworkingmemoryinmice[J].Ethnopharmacol,1999,66:123.[5],,,.GsmRNA[J].,2001,32(11):l000.[6],,,.[J].,2002,25(3):3.[7],,.[J].,1997,8(1):l7.[8],,,.[J].,1994,ll(1):13.[9],.[M].:,1997,535.[10],,,.[J].,1993,14(4):314.[11]HanJA,HuWY,SunZH.EffectofPanaxnotoginsengSaponinonCa2+,CAMincraniocerebralinjury[J].ChineseJournalofIntegratedTra2ditionalandWesternMedicine,1999,19:227.[12],.IL-8[J].,2002,15(5):267.[13],,,.[J].,2002,10(1):90.[14],,,.[J].,1996,27(11):666.[15],,,.GATA-1GATA-2[J].,2004,25(5):281.[16],,.-KB[J].,2001,20(5):279.[17],,.[J].,2000,31(9):676.[18],,,.[J].,2004,4(4):52.[19],,.[J].,2002,22(1):47.[20],,,.HK-2[J].,2004,5(3):143.[21],,,.[J].,2005,15(3):235.[22],.TNFIL-6[J].,2005,21(4):31.[23],,,.[J].,2005,27(24):2410.[24],,,.[J].,2005,22(2):130.[25]LiXH,DongZR,HaoHL.Effectofpanaxnotoginsengsaponinonpro2coagulantactivityanddifferentiationinductioninNB4cells[J].Zhong2guoZhongXiYiJieHeZaZhi,2004,24(1):63.[26],,,.[J].,2001,24(5):29.[27],.[J].,2000,16(5):22.[28],.[J].(),2003,22(6):429.[29],,,.[J].,2004,26(3):212.[30],,,.OPG[J].,2004,10(2):239.25212007185LISHIZHENMEDICINEANDMATERIAMEDICARESEARCH2007VOL.18NO.5