C-反应蛋白临床应用的现状和展望

Wewillcontinuetoimprovethecompany'sinternalcontrolsystem,andsteadyimprovementinabilitytomanageandcontrol,optimizebusinessprocesses,toensuresmoothprocesses,responsibilitiesinplace;tofurtherstrengtheninternalcontrols,playacontrolpostindependentoversightroleofevaluationcomplyingwiththird-partyresponsibility;toactivelymakeuseofinternalaudittoolsdetectpotentialmanagement,streamline,standardizerelatedtransactions,strengtheningoperationsinaccordancewithlaw.Deepeningtheinformationmanagementtoensurefullcommunicationzeroresistance.ToconstantlyperfectERP,andBFS++,andPI,andMIS,andSCM,informationsystembasedconstruction,fullintegrationinformationsystem,achievedinformationresourcesshared;toexpandPortalsystemapplicationofbreadthanddepth,playinformationsystemonenterpriseofAssistantrole;toperfectdailyrunmaintenanceoperationofrecords,promoteproblemreasonsanalysisandsystemhandover;tostrengtheningBFS++,andERP,andSCM,technologyapplicationoftraining,improveemployeesapplicationinformationsystemofcapacityandlevel.Humanisticcaretoensurezero.TostrengtheningHumanitiescare,continuestofostercompanywindclear,andgasare,andheartShunofcultureatmosphere;strengtheninglovehelpedtrapped,caredifficultemployees;carriedoutstyleactivities,richemployeeslife;strengtheninghealthandlabourprotection,organizationcareerhealthmedical,controlcareeragainst;continuestoimplementationpsychologicalwarningpreventionsystem,trainingemployeeshealthofcharacter,andstableofmoodandenterprisingofattitude,createdfriendlyfraternityofHumanitiesenvironment.Tostrengthenriskmanagement,ensurethatthebusinessofzerorisk.Tostrengthenedbusinessplansmanagement,willbusinessbusinessplanscovertoalllevel,ensurethebusinesscancontrolincontrol;tocloseconcernfinancial,andcoalelectriclinkage,andenergy-savingscheduling,nationalpolicytrends,strengtheningtrack,activeshould;toimplementationState-ownedassetsmethod,furtherspecificationbusinessfinancialmanagement;toperfectrisktubecontrolsystem,achievedriskrecognition,andmeasure,andassessment,andreport,andcontrolfeedbackofclosedringmanagement,improveriskpreventioncapacity.Tofurtherstandardizetrading,andstrivetoachieveaccordingtolaw,standardizeandfair.Innovationofperformancemanagement,toensurethatpotentialemployeeszerofly.Tostrengthenperformancemanagement,processcontrol,enhanceemployeeevaluationandlevelsofeffectivecommunicationtoimproveperformancemanagement.Tofurtherquantifyandrefineemployeestandards...Work,fullplayparty,andbranch,andmembersinfivetypeEnterpriseconstructionintheofcorerole,andfightingfortressroleandpioneermodelrole;tocontinuestostrengtheningfourgoodleadershipconstruction利用设在基坑边的固定泵输送砼到施工面，人工摊铺，平板振捣器振捣密实，用刮杠沿模板顶将砼刮平，并用木抹搓平压实，确保砼密实和表面平整。砼浇注时埋设支立模板及钢筋支架所需预埋铁件playlevelscadresinenterprisedevelopmentintheofbackbonebackbonerole;tofullstrengtheningmembersyouthwork,fullplayyouthemployeesincompanydevelopmentintheofforcerole;toimproveindependentCommissionagainstcorruptionworklevel,strengtheningonenterprisebusinesskeylinkofeffectivenessmonitored.,Andmaintainstability.Tofurtherstrengthenpublicityandeducation,improvetheoveralllegalsystem.Wemuststrengthensafetymanagement,establishandimprovetheeducation,supervision,andevaluationasoneofthetrafficsafetymanagementmechanism.ToconscientiouslysumuptheOlympicsecuritycontrols,promotingintegratedmanagementtoahigherlevel,higherstandards,ahigherlevelofdevelopment.Employees,todayislunarcalendaronDecember24,theoxBellisabouttoring,atthistimeofyear,weclearlyfeelthepulseoftheXXpowergenerationcompanytoflourish,tomoreclearlyhearXXpowergenerationcompaniesmatureandsymmetrybreathing.Recallingpastoneanotheracrossarailing,weareenthusiasticandfullofconfidence.Futuredevelopmentopportunities,wemoreexcitingfightmorespirited.Employees,letustogetheracross2013fullofchallengesandopportunities,tocreateagreen,low-costoperation,fullofhumanecareofaworld-classpowergenerationcompanyandworkhard!TheoccasionoftheSpringFestival,mysincerewishthatyouandthefamiliesofthestaffinthenewyear,goodhealth,happy,happy!C-反应蛋白临床应用的现状和展望上海第二医科大学附属新华医院沈霞C－反应蛋白（C－neactiveprotein，简称CRP）早于1930年由Tilet和Fnancis首先发现，作为肺炎双球菌性肺炎的标志物，在钙离子存在的情况下，此蛋白质能与肺炎球菌英膜C多糖物质（C－polysaccharidesubstande，简称CPS）形成复合物，为此命名为C－反应素。1941年Abernethy及Avery确定它是蛋白质，即称之为C－反应蛋白质。此后CRP被用于观察多种疾病的状况，在炎症或组织损伤的情况下的非特异性标志物，并能视为急性反应时相蛋白之一，包括在急性炎症时呈现出其它蛋白质和糖蛋白的增加。CRP由肝细胞合成，分子量为100，000－144，000，由5个相同的亚单位以非共价键聚集而成环状对称五聚体，在血清，脑脊液，关节滑膜炎，羊水，胸腹水和水疱液内均可被检测。CRP不能穿过胎盘，在正常人血清中CRP含量低微，随年龄增长而增长，在疾病发作后几小时CRP含量就有成倍增长趋势，甚至高达2000倍，并较其它时相蛋白增长快而显著，此升高的幅度与感染的程度呈正相关。CRP具有主要调理素作用，能与广谱细菌和组织膜结合，增加吞噬细胞的活性和运动，促进对各种细胞菌和异物的吞噬，起着修复组织和消除炎症的作用。在急性炎症期CRP还伴有免疫系统功能，能与T淋巴细胞特异性地结合，改变或限制这些细胞的某些功能，CRP还能抑制血小板的聚集及活性反应。一、CRP与其它炎症因子的相关性：CRP与其它炎症因子如：多行核白细胞，α－糖蛋白，红细胞沉降率等具有密切相关性，在炎症反应中，吞噬细胞能吞噬细胞并导致白细胞介素I释放，白细胞介素I促使肝脏不断产生CRP，因而CRP含量可成倍上升，而且炎症反应改变了CRP生物合成和分解代谢率，它对分布在体内的微生物及/或改变了的炎症组织上的配体有识别能力，并能与配体结合后固定在补体C1q片断上，形成一个IqG抗原和CRP复合物的激活补体经典途径，使C3转化酶将C3裂解为C3a,C3b,然后C3b与CRP配体形成C3b特异受体可激活吞噬细胞，增强其吞噬的活性和运动，促进对各种细菌和异物的吞噬，起着修复组织和消除炎症的作用，故CRP与WBC存在呈正相关，在炎症反应中起着积极作用，使人体具有非特异性的抵抗力。与ESR相比，CRP在疾病发作时含量增高比ERS更早，回复正常也较快，具有极高的敏感性，而ESR在采血后2小时内进行测定，贫血或蛋白质浓度降低者或某些免疫学状态改变均会影响