基因检测叶酸利用能力的个体差异性临床观察-魏海青

17KuangYQKongBYangTetal．EpileptiformdischargesandfrontalparoxysmalEEGabnormalityactaspredictivemarkerforsubsequentep-ilepsyinchildrenwithcomplexfebrileseizures．ClinEEGNeurosci201445299-303．18KanemuraHMizorogiSAoyagiKetal．EEGcharacteristicspredictsubsequentepilepsyinchildrenwithfebrileseizure．BrainDev201234302-307．19WoSBLeeJHLeeYJetal．Ｒiskfordevelopingepilepsyandepilepti-formdischargesonEEGinpatientswithfebrileseizures．BrainDev201335307-311．20VisserAMJaddoeVWBretelerMMetal．FrequentfeverepisodesandtheriskoffebrileseizurestheGenerationＲstudyEurJPaediatrNeu-rol20121629-34．21GravesＲCOehlerKTingleLEetal．FebrileSeizuresＲisksEvalua-tionandPrognosis．AmericanFamilyPhysician201285149-153．22．．2013352318-2319．2014－12－31doi10．3969/j．issn．1002－7386．2015．14．015··[e-mail]【】。400MTHFＲ-C677T、A1298CMTＲＲ-A66G。TT28%GG6%。、P＜0．05。。。。【】【】Ｒ346．38【】A【】1002－7386201514－2133－03FolicacidBH．K．Mitchell1941。。“”1。1997400μg/d。。400μg。21%38%。、、。905。400μg/d。。。211．1201411240021～40。n=68n=332。21～252226～302631～351036～402。21～256826～3019631～354636～4022。3312201573714HebeiMedicalJournal2015Vol37JulNo.14683236332172160。1．2．。0．9%2DNATaqman-MGBMTHFＲ-C677T、A1298CMTＲＲ-A66GPCＲ、ABI。1．3SPSS17．0χ2P＜0．05。22．1PCＲ、、。2．22．2．1、3、。MTHFＲC677TCCCT、TTTT28%MTHFＲA1298CAA、AC、CCCC4%MTＲＲA66GAA、AG、GGGG6%。1。1%1MTHFＲC677TCCCTTT2250282MTHFＲA1298CAAACCC663143MTＲＲA66GAAAGGG583662．2．2、、、。2。2、、2．2．36811．47%811．76%4972．06%1014．71%。3325015．06%11233．73%14643．98%247．23%。2、、、P＜0．05。3。32%n=6811．47811．764972．061014．71n=3325015．06*11233．73*14643．98*247．23**P＜0．052．2．4MTHFＲ、MTＲＲ3400μg/d3、、400μg/d3400μg/d800μg/d400μg/d3800μg/d400μg/d。3、、/。4。3B。。124312201573714HebeiMedicalJournal2015Vol37JulNo.144μg/d34004004008000～12400400800800/13～40400400400。。4。、、、5。MTHFＲ510-methyle-netetrahydrofolatereductase510-C677TCCCTTT22%50%28%。MTHFＲA1298CAAACCC66%31%4%。MTＲＲ5-methyl-tetrahydrofolate-homocysteinemethyltransferasereductaseA66GAAAGGG58%36%6%。MTHFＲ、MTＲＲ6、、、、、。7。2007“”“。”“”15“”。8。MTHFＲMTＲＲ910。。P＜0．05。。。1LambNEYuKShafferJetal．Associationbetweenmater-nalageandmeioticrecombinationfortrisomy．AmJHumGenet20057691．2PopielaAKeithGBorzeckiAetal．ThemeaningofthemehylationofgenomicDNAintheregulationofgeneexpres-sionlevels．EurJGynaecolOncol200425145．3．．20101935-37．4．．20112745-47．5．PCＲ．20101032-35．6．．201246-10．7．240、．20062119-21．8．2012．20143895-97．9．406．201324432-434．10．、．2013403009-3011．2015－01－085312201573714HebeiMedicalJournal2015Vol37JulNo.14