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王 焱 张志文(100083)概述了钙在机体中的作用、钙的调节和影响钙吸收、排泄、储留的因素。指出了不同年龄的人对钙的需要量、食物的含钙量。还分析了钙摄入不足、摄入过多和钙代谢障碍所致的疾病。 钙 PTH 降钙素 VitaminD3 佝偻病 低钙惊厥 骨质疏松症,1300g,1.5%2.0%,99%,2.12.6mg/L35%;60%,5%,,,1,,,,,0.5g,,,40,,1%,,,,,,,,,,()(),,,,,,,,,,,,()()(),2(PTH)VitaminDPTH84,1078,N613,C,G,GC,C(IP3),PTH,PHT,PTH,;PTH;,PTH14200136625(OH)VitaminD31.25(OH)2VitaminD3,PTH1.25(OH)2D3(calcitonin,CT)(C),32CTC,CT,,,,,;CT,,VitaminD7-,VitaminD3,VitaminD3,2511,1.25(OH)2VitaminD31.25(OH)2VitaminD3PTH,PTH1.25(OH)2VitaminD3,1.25(OH)2VitaminD3VitaminD1.25-VitaminD3,;,,,;,,5%,30min33.1VitaminD,(),,,pH,,,,5%,,PTH,,60,70792059,1/3,,3.2,,,,,,,,,=+,,20%3.3,,,PTH1.25(OH)2VitaminD3,41840600mg/d(),,,,1.25(OH)2D3FAO/WHO(/)31200mg/d110VitaminD600mg/d,,VitaminD,,:10152001366600mg/d,1013800mg/d,13161200mg/d,16191000mg/d,600mg/d,1500mg/d,2000mg/d,,,,,120mg/100ml,500ml,80%23000,100106,,,,55.1,VitaminD,VitaminD,,,,,,,32,,,,,,,OX,,,:DD,10min2h,,D5.2,30,,,,,651/4;50,1/12,:1)2)3),,,,,,,,,,D,,,,,D,,5.3,,80%,,,,5.4D,,43D,,,,,,:,D,24D,D,,,,61TomBrody,CalciumandPhosphate.NutritionalBiochem-istry.1999,761794.2NIHConsensusDevelopmentPanelonOptionalCalciumIntake.Optionalcalciumintake.JAMA272,1994,19421948.3Sheikh,M.S.,Gastrointestinalabsorptionofcalciumfrommilkandcalciumsalts.N.Emgl.Med.317,1987,532536.4Johnston,C.Miller,J.Z,Slemenda,C.Calciumsupplemen-tationandincreasesinbonemineraldensityinchildren1992,N.Engl.J.Med.327.8287.5Sahni,M.,Guenther,H.l.,Biophosophonatesactonboneresorptionthroughthemediationofosteoblasts.J.Clin.Inves.91,1993,20042011.(BF)162001366