:050011,,,,,,,,,,,,,,2007Hinestrosa[1]Nature(Shapingthefutureofbiomarkerresearchinbreastcancertoensureclinicalrelevance),,,,1(tumorbiomarkers)1978Herberman(NCI),,,,,,[2],,(prostatespecificanfigen,PSA),9()2009231ChinJBreastDis(ElectronicEdition),February2009,Vol.3,No.1©1994-2012ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:(1);(2);(3);(4);(5);(6)(1)[3-8]2:(1);(2),,,,;(3),,[7]:(1),100%;(2),,;(3),;(4),;(5),(6),[1][1]:(1):,,(AFP)EBIgA(VCA2IgA),,,,(2):,,,,,(3):,,,01()2009231ChinJBreastDis(ElectronicEdition),February2009,Vol.3,No.1©1994-2012ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(CEA)(AFP)CA125CA50CA1523CA1929CA242CA7224(PAP)(PSA)(Free2PSA)(NSE)2L2(AFU)(HGH)(2HCG)()(Ferritin,Fe)LHIV,(TPA)2(22microglobulin,2m),(Bence2Jonesprotein,BJP)(N2mycc2erbB22N2rasc2mycH2rasK2ras)11()2009231ChinJBreastDis(ElectronicEdition),February2009,Vol.3,No.1©1994-2012ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.:HER22/neu(c2erbB22)CA1523BR27.29(CA27.29)CEA:(EGFR)D(uPA)(tPA)3.1(ER/PR)ER/PR(tamoxifen)ER/PR,()(),(15fmol),10fmol()15fmol(),;ER/PR,(ER2)(ER2)DNA(96%58%),ER2ER2(PR),ER2,ER2[9]3.2HER22/neu(c2erbB22)HER22/neu(c2erbB22),185000,,EGF:HER22/neu,3HER22/neu,,,Herceptin[10],HER22/neu3.31523(CA1523)CA15231984HilkensMAM26(1152DB);1984Kufu21()2009231ChinJBreastDis(ElectronicEdition),February2009,Vol.3,No.1©1994-2012ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(DF23),CA1523,CA1523100103U/L,,,CA1523;CA1523CA1523,23%69%CA1523;,1020%,1997FDAMucin1(CA1523)/3.4BR27.29(CA27.29)BR27.29(CA1523),(MUC21)BR27.29CA1523DF3BR27.293.5(carcino2embryonicantigen,CEA)CEA1965GoldFreedman,CEA19CEA,,CEA,,CEA,,3.6(EGF)6000,EGF,EGFATPEGF,EGFEGF,,EGFEGF(),EGF(ASCO)31()2009231ChinJBreastDis(ElectronicEdition),February2009,Vol.3,No.1©1994-2012ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.(EIA)(ELISA)D,,D,ASCO,D3.8(uPA)(tPA),,tPA,uPAuPA(pro2uPA),(uPAR)()pro2uPApro2uPA(Mr52000),[A(158,Mr32000),B(253,Mr20000)]uPA,()(PAI21PAI22),uPA,uPA()uPAPAI21PAI22:uPAPAI21PAI22,uPAPAI21,ELISA41()2009231ChinJBreastDis(ElectronicEdition),February2009,Vol.3,No.1©1994-2012ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.[1]HinestrosaMC,DickersinK,KleinP,etal.Shapingthefutureofbiomarkerresearchinbreastcancertoensureclinicalrelevance.Nature,2007,7:311-315.[2]..,2004,27:393.[3]WrtzSÁ,HenriksenKL,LykkesfeldtA,etal.Integrationofnewandfuturebiomarkersinthetreatmentofbreastcanc2er.UgeskrLaeger,2007,169:2999-3003.[4]OstrowskiSR,KatzensteinTL,PedersenBK,etal.ResidualviraemiainHIV212infectedpatientswithplasmaviralloador=20copies/mlisassociatedwithincreasedbloodlevelsofsolubleimmuneactivationmarkers.ScandJImmunol,2008,68:652-660.[5]PeyromaureM.PSA:anewprostatecancermarker.ProgUrol,2004,14:8-11.[6]SabouryAA,AtriMS,SanatiMH,etal.Athermodynamicstudyontheinteractionbetweenmagnesiumionandhumangrowthhormone.Biopolymers,2006,81:120-126.[7]OchiY,OkabeH,InuiT,etal.Tumormarker2presentandfuture.RinshoByori,1997,45:875-883.[8]NicoliniA,TartarelliG,CarpiA,etal.Intensivepost2operativefollow2upofbreastcancerpatientswithtumourmarkers:CEA,TPAorCA15.3vsMCAandMCA2CA15.3vsCEA2TPA2CA15.3panelintheearlydetectionofdistantmetastases.BMCCancer,2006,6:269-278.[9]YangXR,PfeifferRM,GarciaClosasM,etal.Hormonalmarkersinbreastcancer:co2expression,relationshipwithpath2ologiccharacteristics,andriskfactorassociationsinapopulation2basedstudy.CancerRes,2007,67:10608-10617.[10]AgrawalAK,JeleM,RudnickiJ,etal.Molecularmarkers(c2erbB22,p53)inbreastcancer.FoliaHistochemCytobi2ol,2008,46:449-455.;R737.9A(:2009201220)(:).[J/CD].:,2009,3(1):9-15.51()2009231ChinJBreastDis(ElectronicEdition),February2009,Vol.3,No.1©1994-2012ChinaAcademicJournalElectronicPublishingHouse.Allrightsreserved.