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2005200062cjing1221@163.com207030100875,deepsea_001@mail.bnu.edu.cn200240jpcheng@sjtu.edu.cn70@igsnrr.ac.cn101010101010100101fengfj@igsnrr.ac.cnGB/T4633-1997WS/T88-199650ml5%90.3%107.6%0.456.75mg/kg710062,gemiao@yahoo.com.cn273(X1)(X2)(X3)(X4)(X5)(r)r1=0.850r2=0.414r3=-0.632r4=-0.802r5=-0.582.(F=257.90)^Y1=151.0+0.006923X1-1.143X4+0.006789X522.3^Y(g/L)X1(m)X4()X5(mm)22.31.96430079shshgong@hotmail.com123333451250012chenghaoguo@sdu.edu.cn;2;3;4;5Budd-ChiariSyndromeB-CS700B-CS128128,98.44%150g/L150300g/L27.35%300g/L71.09%1.56%1.02.0mg/L75.0%2.04.0mg/L23.44%BCS@sina.com----NH4+-NDPNH4+-NDPNH4+-NNO2--NNO3--NDPNH4+-NNO2--NNO3--N12111330027jianminfei0914@163.com2330029Non-pointsource,NPS97.5%.1,23131313434331.100101lihl@igsnrr.ac.cn(4162771mg/L)(P0.01)100101lihr@igsnrr.ac.cn1970Berlyne@163.com1,211111100101lisj@igsnrr.ac.cn2100039200456364820SPSS11.5p0.05(p0.05)400038liweiminy@163.com21400061.6%(98/159)47.6%(50/105)46%52%219874538kg55.77%10.82%33.47%41%3@igsnrr.ac.cn150km5~10km50%12013153.114.816.1Muller--241000mahongkang3218@sohu.com0.84=V/r00.84@yahoo.com.cnPOPsPOPsPOPsPOPsPOPsHCHsDDTsPCBsOCPs-HCH-HCH-HCH-HCHp,p-DDEo,p-DDTp,p-DDTp,p-DDD-HCH-HCH-HCH-HCHp,p-DDEo,p-DDTp,p-DDDp,p-DDTPCBsCBPOPsHCHsDDTsPCBs230027Ruandy@ustc.edu.cn198828,51.6%100g/L,1999838.8%1030%80%;;,,1LTPLTDLTPLTDLTP34%LTD28%2Ca++,Ca++Pb++Ca++Ca++Pb++Ca++PKCPKC-cAMP-,K+K+K+3NMDANMDA(),K+()5c-fosc-jun,mRNADNA,,,DNAcAMPPKACREB6,,,,LTPLTPCa2+-GlsNMDA100101sunx.03s@igsnrr..ac.cnAsAsAsAs,130026,tangjie@jlu.edu.cn(nAChRs)modulatestheinductionoflong-termpotentiation(LTP),oneofthepossiblecellularmechanismsforlearning.Toinvestigatetheeffectofnicotine(NIC)onsynapticplasticityinchroniclead-exposedrat,fieldexcitatorypostsynapticpotentials(fEPSP)andpaired-pulsefacilitation(PPF)wererecordedintheCA1areaofhippocampalslicesexposedtolead.Theresultsshowedthat:(1)NIC(1M)facilitatedtheinductionofLTPinCA1areaofthehippocampusbyaweaktetanicstimulation(100Hz,20Pulses),whichdoesnotbyitselfproduceLTPinlead-exposedrats.Thiseffectwassignificantlysuppressedbymecamylamine(MEC;5M),anonselectivenicotinicantagonist,suggestingthatloweredthethresholdforLTPinthechroniclead-exposedratbynicotineisthroughnAChRs.(2)Thenicotine-mediatedLTPwasblockedbydihydro--erythroidine(DhE1M),astrongantagonistofthenAChRscontaining42subunits.Whilelong-termdepression(LTD)wasproducedbythecombinationofNICandmethyllycaconitine(MLA;10nM),anantagonistofnAChRscontaining7subunits;neitherLTPnorLTDwasobservedbythecombinationofNIC,MLAandDHE.ItimpliesthatseveralnAChRssubtypesareinvolvedinthenicotine-mediatedsynapticplasticity.(3)NICapplicationenhancedpaired-pulsefacilitation(PPF)inhippocampalCA1region,andthenicotine-mediatedLTPinlead-exposedratswasreversedbytheapplicationofeitherD-(-)-2-amino-5-phosphonopentanoicacid(D-AP5;50M)£¬theNMDAreceptorantagonist,or(PTX;50M),anantagonistof-aminobutyricacid(GABA)Areceptor.Theseresultssuggestedthatnicotine-mediatedsynapticplasticityisduetotheenhancementofNMDARresponsesbydisinhibitionofpyramidalcellsthroughpresynapticnAChRs.Thismayrepresentthecellularbasisofnicotine-mediatedcognitiveenhancementobservedinchroniclead-exposedrats.ThisworkwassupportedbyTheNationalBasicResearchProgramofChina(No.2002CB512907),AcademiaSinica(No.KZCX3-SW-437).13131,23131.100101wangwy@igsnrr.ac.cn2.1000393.162650()932050X34235024.5116.87g/g1.120.48g/ml4.441.71g/ml6.021.79mg/L1.351.01g/g0.0950.047g/ml2.291.70g/ml2.991.11mg/L5.802.14g/g0.230.10g/ml2.191.34g/ml1.311.06g/g0.0330.008g/ml0.610.39g/mlX86.361111,21100101weicy@igsnrr.ac.cn2430070/@yahoo.com.cn2,33002914200193119371979198020042004030006xuehuifang1976@126.com2000747GDPTSPSO2NO215926481545GDP5.5%@igsnrr.ac.cn/510405,yangmz@21cn.net,1.52.01,21111.100101yebx.04b@igsnrr.ac.cn@student.ecnu.edu.cn-NH4+-NNH4+-NNO3--N100101yujp@igsnrr.ac.cn8844.7%P0.0585.7%P0.01SO275%(P0.05)55.3%P0.0550%53%@igsnrr.ac.cn2100053280320nmB(UVB)sdisort19471UVB1km2111320%ICNIRP30J/m2