鹰嘴豆化学成分及药理作用研究进展-李朋收

2[e-mail]*[e-mail]李朋收，刘洋洋，范冰舵，魏茜，李春娜，徐暾海*，刘铜华(北京中医药大学中医养生学教育部重点实验室，北京100029)。、、、、、。Aβ-β-BbA、、、、、、。、。、CaCo-2、、。。Ｒ285．5Ｒ284．1A1005-9903201411-0235-04doi10．13422/j．cnki．syfjx．2014110235http//．cnki．net/kcms/detail/11．3495．Ｒ．20140324．1546．008．html2014-03-241546ＲesearchProgressofChemicalCompositionandPharmacologicalEffectivenessofChickpeasLIPeng-shouLIUYang-yangFANBing-duoWEIQianLIChun-naXUTun-hai*LIUTong-huaBeijingUniversityofChineseMedicineHealthCultivationLaboratoryoftheMinistryofEducationBeijing100029ChinaAbstractThispaperconcludedandsummarizedchemicalconstituentsandpharmacologicaleffectsofChickpeareportedintheliteratureathomeandabroadinrecentyearsandsummarizedchemicalcompositionandpharmacologicaleffectivenessofChickpeaforprovidingthebasisofresearchingthechemicalconstituentsofchickpeaanddiscoveryoftheactiveingredientinthefuture．ThroughliteraturestudywhichfoundthatChickpeacontainedavarietyofnutrientsandessentialsubstancesuchasdextransucrosechickpeasglucoseandarabinosewithdextrancholinephospholipidsvariousvitaminsaminoacidsandpantothenicacidandphyticacidandcontainsallkindsoftraceelementssuchasphosphoruscalciumironzincetcandtheunsaturatedfattyacidswhichhumanbodycouldnotsynthesize．Itspresentstudyofactiveingredientsmainlyistriterpenoidsaponinsandisoflavones．TriterpenoidsaponinswhichhasnowgainedfrommajorincludesbiochaninAβ-amyrinβ-sitosterolsoyasaponinBbandcarrotssoybeansaponinglycosidesetalandisoflavonesincludesbiochaninAformononetin·532·201120146ChineseJournalofExperimentalTraditionalMedicalFormulaeVol．20No．11Jun．2014genisteincalycosinononintrifolirhizinsissotrin．Thesetriterpenoidsaponinsandisoflavonescouldregulatebloodsugarlowerbloodlipidsandhavemanyotherpharmacologicaleffects．InadditionthechickpeasandthemainactiveingredientalsohaslowercholesterolinhibitCaCo-2cellsimprovelearningandmemoryabilityinhibittumorcellgrowthandsoon．Differerntkindsofsubstancesofchickpeasatdifferentgrowthstagesareconstantlychangingandalsoplayadifferenttreatmentfordifferentdiseases．Wewouldfindmorechemicalcompositionofchickpeawiththedeepeningofresearchandtheactiveingredientswouldgraduallybescreenedwhichwouldgreatlyexpandthescopeofapplicationofchickpea．KeywordsChickpeachemicalcompositionpharmacologicaleffectivenessChickpea、、。。、、、、、、。、、。《》、《》18、、、B1、B2、C、E、。。1《》1、、、、。、、。、、。、A、C。、7-、4-。、、、、、、、。。1.124AsoyasapoginolA、β-β-amyrin、β-β-sitosterolBbsoyasaponinBb4。3、SephadexLH-20D1013---12-。4β-β-3。56β-。1.23A-7-O-β-D-3～4cmA。6AA、、、、、。1.3412＇4＇-dihydroxy-67-methlenedioxyflavanol。1.466、、、Z-、E-、811-383.59%82.57%81.86%。。5。4。1.57、、、。、、、、、、、、、、、、、、、、。1.63、1--α-L、、、。5p-hydroxybenzoicacid、adenosine、12-2-12-benzenndicarboxylicacid12-bis2-methylpropylester、1--α-L-1-ethyl-α-L-galactoside、sucrose。PoltronieriF8、、、、。6-810--1-、。22.19·632·201120146ChineseJournalofExperimentalTraditionalMedicalFormulaeVol．20No．11Jun．2014P＜0.01。P＜0.01。2.2。NestelP10P＜0.05HOMAP=0.05。。JohnsonSKOakenfullDG11-12。1370%。。·142、、CAT、TSOD、GSH-PxMDACAT2。15。。·162。2P＜0.01-6。。2.317TC、、TGP＜0.01P＜0.05。P＜0.05。18SOD。。2.4Caco-219Caco-2Caco-2。2.520P＜0.01。SODMDAP＜0.05P＜0.01。2.6、。MoonYJ21AHanEH22AAhＲ。ＲiceL23ALNCaPde。JohnsonTL24AEＲKBAkt。HIVHIV。25AHIV-1HIV-1CD4。。3、、。。、。、。。、、。、。·732·AHIV。、。1．M．1986596.2·．J．2010253188.3．J．200732161650.4WUXiaWANGZhi-QianYEYun-Huaetal．AnewdihydroxyflavanolfromtheseedofCicerarietinumJ．ChinJNatMed20108291.5．J．20128741.6．D．2007.7．J．2007141152.8PoltronieriFAreasJAColiC．ExtrusionandbioavailabilityinchickpeaCicerarietinumLJ．FoodChem200070175.9．J．200527999.10NestelPCehunMChronopoulosA．Effectsoflong-termconsumptionandsinglemealsofchickpeasonplasmaglucoseinsulinandtriacylglycerolconcerntrationJ．AmJClinNutr200479390.11JohnsonSKThomasSJHallＲS．PalatabilityandglucoseinsulinandsatietyresponsesofchickpeaflourandextrudedchickpeaflourbreadeatenaspartofabreakfastJ．EurJClinNutr2005592169.12OakenfullDGSidhuGS．PreventionofdietaryhypercholesterolaemiabychickpeasponinsandnavybeansJ．ProcNutrSocAust19849104.13·．J．200729121832.14·．2J．2012283154.15．-J．200738117625.16·．2J．20113381405.17．J．200524462.18．J．20059780.19．Caco-2J．2011215469.20．D-J．2011425969.21MoonYJ．BiochaninAinhibitsbreastcancertumorgrowthinamurinexenograftmodelJ．PharmＲes20082592158.22HanEH．EffectofbiochaninAonthearylhydrocarbonreceptorandcytochromeP4501A1inMCF-7humanbreastcarcinomacellsJ．ArchPharmＲes2006297570.23ＲiceL．MechanismofthegrowthinhibitoryeffectsoftheisoflavonoidbiochaninAonLNCaPcellsandxenograftsJ．Prostate2002523201.24JohnsonTL．InhibitionofcellproliferatioandMAPkinaseandAktpathwaysinoralsquamouscellcarcinomabygenisteinandbiochaninAJ．EvidBasedComplementAlternatMed200829216.25．AHIV-1CD4J．2007232214.·832·201120146ChineseJournalofExperimentalTraditionalMedicalFormulaeVol．20No．11Jun．2014